IQVIA_Rules_Based_Medicine_Logo - rgb

(+01) 512 835 8026

Email us

Type your search term and press "enter."

AdobeStock_624012739

CNS and neuroscience biomarkers

Central Nervous System (CNS) and neurology biomarkers provide valuable insights into neurological health and disease mechanisms. The identification and characterization of novel biomarkers for neurodegenerative, neuropsychiatric, and neuromuscular diseases support the early detection of conditions and the development of therapeutic intervention. RBM offers numerous biomarkers involved in the onset, progression and monitoring of various conditions. Monitoring these biomarkers can help evaluate the safety and efficacy of therapeutics for various CNS conditions, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and neuroinflammatory conditions.

 

Alpha-1-Antichymotrypsin and Alpha-2-Macroglobulin are acute-phase proteins associated with neuroinflammation. Beta Amyloid (1-40 and 1-42) are key components of amyloid plaques in Alzheimer's disease. Brain-Derived Neurotrophic Factor (BDNF) supports neuronal survival and plasticity. Cathepsins (B, D) are involved in protein degradation and have roles in neurodegenerative conditions. Chromogranin-A is a marker of neuroendocrine activity. Ciliary Neurotrophic Factor (CNTF) supports neuronal survival.

 

Clusterin is linked to Alzheimer's disease pathology. Complement C3 and Complement Factor H-Related Protein 1 are involved in immune response. Contactin-1 is important for neural cell adhesion. Galanin modulates pain and mood. Granulocyte Colony-Stimulating Factor (G-CSF) supports neuroprotection. Insulin-like Growth Factor I (IGF-I) promotes neurogenesis. Matrix Metalloproteinase-9 (MMP-9) is linked to blood-brain barrier disruption. Nerve Growth Factor beta (NGF-β) supports neuronal growth. Neural Cell Adhesion Molecule 1 (NCAM-1) is important for neural development. Neuron-Specific Enolase (NSE) is a marker of neuronal damage. Neuronal Cell Adhesion Molecule (NrCAM) supports neuronal signaling. Neuropilin-1 is involved in axon guidance.

 

Platelet-Derived Growth Factor BB (PDGF-BB) supports neuroprotection. Prolactin affects neuroendocrine function. Receptor for Advanced Glycation End Products (RAGE) is involved in neuroinflammation. S100 calcium-binding protein B (S100B) is a marker of astrocyte activation. Serum Amyloid P-Component (SAP) is linked to amyloid deposition. T-Cell-Specific Protein RANTES is a chemokine involved in neuroinflammation. Tenascin-C supports neural development. Thrombospondin-4 is linked to synaptogenesis. Tissue type Plasminogen Activator (tPA) is involved in fibrinolysis. Vascular Endothelial Growth Factor (VEGF) supports blood vessel formation. 

Multiplexes with CNS biomarkers

The biomarkers below have demonstrated links to CNS conditions in the scientific literature.
1. Interferon gamma Induced Protein 10 2. Interferon-inducible T-cell alpha chemoattractant 3. Interleukin-1 beta 4. Interleukin-6 receptor 5. Interleukin-8 6. Lumican 7. Matrix Metalloproteinase-9 8. Nerve Growth Factor beta 9. Neural Cell Adhesion Molecule 1 10. Neuron-Specific Enolase 11. Neuronal Cell Adhesion Molecule 12. Neuropilin-1 13. Plasminogen Activator Inhibitor 1 14. Platelet-Derived Growth Factor BB 15. Prolactin 16. Receptor for advanced glycosylation end products 17. S100 calcium-binding protein B 18. Serum Amyloid P-Component 19. Superoxide Dismutase 1, soluble 20. T-Cell-Specific Protein RANTES 21. Tenascin-C 22. Thrombomodulin 23. Thrombospondin-4 24. Tissue type Plasminogen activator 25. Transforming Growth Factor alpha 26. Transthyretin 27. Tyrosine kinase with Ig and EGF homology domains 2 28. Urokinase-type Plasminogen Activator 29. Vascular Cell Adhesion Molecule-1 30. Vascular Endothelial Growth Factor 31. Agouti-Related Protein 32. Alpha-1-Antichymotrypsin 33. Alpha-2-Macroglobulin 34. Apolipoprotein A-I 35. Apolipoprotein C-III 36. Apolipoprotein E 37. Beta Amyloid 1-40 38. Beta Amyloid 1-42 39. Beta-2-Microglobulin 40. Beta-hexosaminidase subunit alpha 41. Brain-Derived Neurotrophic Factor 42. C-Reactive Protein 43. Cathepsin B (pro) 44. Cathepsin D 45. CD 40 antigen 46. Chromogranin-A 47. Ciliary Neurotrophic Factor 48. Clusterin 49. Complement C3 50. Complement Factor H - Related Protein 1 51. Contactin-1 52. Cortisol 53. Cystatin-C 54. Galanin 55. Granulocyte Colony-Stimulating Factor 56. Haptoglobin 57. Hemopexin 58. Insulin-like Growth Factor I 59. Intercellular Adhesion Molecule 1