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CNS and neuroscience biomarkers

Central Nervous System (CNS) and neurology biomarkers provide valuable insights into neurological health and disease mechanisms. The identification and characterization of novel biomarkers for neurodegenerative, neuropsychiatric, and neuromuscular diseases support the early detection of conditions and the development of therapeutic intervention. RBM offers numerous biomarkers involved in the onset, progression and monitoring of various conditions. Monitoring these biomarkers can help evaluate the safety and efficacy of therapeutics for various CNS conditions, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and neuroinflammatory conditions.

 

Alpha-1-Antichymotrypsin and Alpha-2-Macroglobulin are acute-phase proteins associated with neuroinflammation. Beta Amyloid (1-40 and 1-42) are key components of amyloid plaques in Alzheimer's disease. Brain-Derived Neurotrophic Factor (BDNF) supports neuronal survival and plasticity. Cathepsins (B, D) are involved in protein degradation and have roles in neurodegenerative conditions. Chromogranin-A is a marker of neuroendocrine activity. Ciliary Neurotrophic Factor (CNTF) supports neuronal survival.

 

Clusterin is linked to Alzheimer's disease pathology. Complement C3 and Complement Factor H-Related Protein 1 are involved in immune response. Contactin-1 is important for neural cell adhesion. Galanin modulates pain and mood. Granulocyte Colony-Stimulating Factor (G-CSF) supports neuroprotection. Insulin-like Growth Factor I (IGF-I) promotes neurogenesis. Matrix Metalloproteinase-9 (MMP-9) is linked to blood-brain barrier disruption. Nerve Growth Factor beta (NGF-β) supports neuronal growth. Neural Cell Adhesion Molecule 1 (NCAM-1) is important for neural development. Neuron-Specific Enolase (NSE) is a marker of neuronal damage. Neuronal Cell Adhesion Molecule (NrCAM) supports neuronal signaling. Neuropilin-1 is involved in axon guidance.

 

Platelet-Derived Growth Factor BB (PDGF-BB) supports neuroprotection. Prolactin affects neuroendocrine function. Receptor for Advanced Glycation End Products (RAGE) is involved in neuroinflammation. S100 calcium-binding protein B (S100B) is a marker of astrocyte activation. Serum Amyloid P-Component (SAP) is linked to amyloid deposition. T-Cell-Specific Protein RANTES is a chemokine involved in neuroinflammation. Tenascin-C supports neural development. Thrombospondin-4 is linked to synaptogenesis. Tissue type Plasminogen Activator (tPA) is involved in fibrinolysis. Vascular Endothelial Growth Factor (VEGF) supports blood vessel formation. 

Multiplexes with CNS biomarkers

The biomarkers below have demonstrated links to CNS conditions in the scientific literature.
1. Agouti-Related Protein 2. Alpha-1-Antichymotrypsin 3. Alpha-2-Macroglobulin 4. Apolipoprotein A-I 5. Apolipoprotein C-III 6. Apolipoprotein E 7. Beta Amyloid 1-40 8. Beta Amyloid 1-42 9. Beta-2-Microglobulin 10. Beta-hexosaminidase subunit alpha 11. Brain-Derived Neurotrophic Factor 12. C-Reactive Protein 13. Cathepsin B (pro) 14. Cathepsin D 15. CD 40 antigen 16. Chromogranin-A 17. Ciliary Neurotrophic Factor 18. Clusterin 19. Complement C3 20. Complement Factor H - Related Protein 1 21. Contactin-1 22. Cortisol 23. Cystatin-C 24. Galanin 25. Granulocyte Colony-Stimulating Factor 26. Haptoglobin 27. Hemopexin 28. Insulin-like Growth Factor I 29. Intercellular Adhesion Molecule 1 30. Interferon gamma Induced Protein 10 31. Interferon-inducible T-cell alpha chemoattractant 32. Interleukin-1 beta 33. Interleukin-6 receptor 34. Interleukin-8 35. Lumican 36. Matrix Metalloproteinase-9 37. Nerve Growth Factor beta 38. Neural Cell Adhesion Molecule 1 39. Neuron-Specific Enolase 40. Neuronal Cell Adhesion Molecule 41. Neuropilin-1 42. Plasminogen Activator Inhibitor 1 43. Platelet-Derived Growth Factor BB 44. Prolactin 45. Receptor for advanced glycosylation end products 46. S100 calcium-binding protein B 47. Serum Amyloid P-Component 48. Superoxide Dismutase 1, soluble 49. T-Cell-Specific Protein RANTES 50. Tenascin-C 51. Thrombomodulin 52. Thrombospondin-4 53. Tissue type Plasminogen activator 54. Transforming Growth Factor alpha 55. Transthyretin 56. Tyrosine kinase with Ig and EGF homology domains 2 57. Urokinase-type Plasminogen Activator 58. Vascular Cell Adhesion Molecule-1 59. Vascular Endothelial Growth Factor