Blood-based biomarkers for obesity and metabolic conditions in clinical research
Obesity and related cardiometabolic conditions are key targets for the development of new therapeutics. Obesity clinical trials increased 68% from 2022 to 2023, with 124 drugs in active development.
Assessing multiple analytes can help identify mechanisms of action associated with dysregulation and evaluate the efficacy of drug candidates. Rules-Based Medicine delivers high-throughput multiplexed assays on the Luminex platform and ultrasensitive Simoa assays, as well as the Olink Target 48 Cytokine panel to support your obesity trials.
Biomarkers associated with obesity and related metabolic conditions, include:
- Adipokines
- Adiponectin, leptin, and resistin
- Fatty-acid-binding protein 4 (FABP4)
- Inflammatory markers
- C-reactive protein, interleukin-6 (IL-6)
- Tumor necrosis factor alpha (TNFα)
- Metabolic markers
- Insulin, insulin-like growth factors (IGFs)
- C-peptide
| Obesity- and metabolic-associated biomarkers | ||
| Adiponectin | Growth hormone | Insulin |
| Apolipoprotein (a) | Growth-regulated alpha protein | Leptin |
| B-cell activating factor | Interferon (IFN) gamma | Luteinizing hormone |
| Brain-derived neurotrophic factor | Intercellular adhesion molecule 1 | Macrophage inflammatory protein-1 alpha |
| C-reactive protein | IL-1 alpha | Matrix metalloproteinase-3 |
| Clusterin | IL-1 beta | Matrix metalloproteinase-9 |
| Eotaxin-1 | IL-1 receptor alpha | Neutrophil gelatinase-associated lipocalin |
| Epithelial-derived neutrophil-activating protein 78 | IL-2 | Monocyte chemotactic protein 1 |
|
Erythropoietin |
IL-3 |
Plasminogen activator inhibitor 1 |
| Factor VII | IL-4 | Pulmonary and activation-regulated chemokine |
| Fibroblast growth factor 21 | IL-5 | Resistin |
| Fibroblast growth factor 23 | IL-6 | Stem cell factor |
| Follicle-stimulating hormone | IL-7 | Thyroid-stimulating hormone |
| Ghrelin | IL-8 | Tumor necrosis factor (TNF) alpha |
| Glucagon-like peptide 1, total | IL-10 | Tumor necrosis factor (TNF) beta |
| Granulocyte colony-stimulating factor | IL-17 | Vascular endothelial growth factor |
| Granulocyte-macrophage colony-stimulating factor | IL-18 | |
Our assays require very low sample volumes and most are available as part of our Luminex-based multi-analyte profiles (MAPs). Many of the interleukin assays are also available as an ultrasensitive Simoa assay. Complete this form and let us know how we can support your next study.
Or see our full biomarker menu for available assays.
