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Cytokine and chemokine biomarkers

Cytokines and chemokines are small signaling proteins that play crucial roles in the immune system by mediating communication between cells. Cytokines, such as interleukins, interferons, and tumor necrosis factors (TNFs), regulate immune responses, inflammation, and cell proliferation. Chemokines, a subset of cytokines, are primarily involved in directing the movement of immune cells to sites of infection or injury.

RBM offers a number of cytokines and chemokines useful in assessing potential therapeutics.  For instance, cytokines can be used as therapeutic agents to boost the immune response in cancer immunotherapy or to suppress inflammation in autoimmune diseases. Additionally, blocking specific cytokines or chemokines can help treat conditions like rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Multiplexes with cytokines and chemokines

The biomarkers below include cytokines and chemokines with demonstrated links to immune and inflammatory processes in the scientific literature.
1. 6Ckine 2. Adiponectin 3. Agouti-Related Protein 4. Amphiregulin 5. Angiogenin 6. Angiopoietin-1 7. Angiopoietin-2 8. AXL Receptor Tyrosine Kinase 9. B cell-activating factor 10. B Lymphocyte Chemoattractant 11. Betacellulin 12. Bone Morphogenetic Protein 6 13. Brain-Derived Neurotrophic Factor 14. Cadherin-1 15. CD40 Ligand 16. CD5 Antigen-like 17. Chemokine CC-4 18. Ciliary Neurotrophic Factor 19. E-Selectin 20. EN-RAGE 21. Endostatin 22. Eotaxin-1 23. Eotaxin-2 24. Eotaxin-3 25. Epidermal Growth Factor 26. Epidermal Growth Factor Receptor 27. Epithelial-Derived Neutrophil-Activating Protein 78 28. Fas Ligand 29. FASLG Receptor 30. Fibroblast Growth Factor 4 31. Fibroblast Growth Factor basic 32. Glucose-6-phosphate Isomerase 33. Granulocyte Colony-Stimulating Factor 34. Granulocyte-Macrophage Colony-Stimulating Factor 35. Growth-Regulated alpha protein 36. Hepatocyte Growth Factor 37. Hepatocyte Growth Factor receptor 38. Insulin-like Growth Factor Binding Protein 4 39. Insulin-like Growth Factor Binding Protein 5 40. Insulin-like Growth Factor Binding Protein 6 41. Insulin-like Growth Factor I 42. Insulin-like Growth Factor II 43. Insulin-like Growth Factor-Binding Protein 1 44. Insulin-like Growth Factor-Binding Protein 2 45. Insulin-like Growth Factor-Binding Protein 3 46. Intercellular Adhesion Molecule 1 47. Interferon gamma 48. Interferon gamma Induced Protein 10 49. Interferon gamma Induced Protein 10, long 50. Interferon gamma Induced Protein 10, short 51. Interferon-inducible T-cell alpha chemoattractant 52. Interleukin-1 alpha 53. Interleukin-1 beta 54. Interleukin-1 receptor antagonist 55. Interleukin-10 56. Interleukin-11 57. Interleukin-12 Subunit p40 58. Interleukin-12 Subunit p70 59. Interleukin-13 60. Interleukin-15 61. Interleukin-16 62. Interleukin-17 63. Interleukin-18 64. Interleukin-18-binding protein 65. Interleukin-2 66. Interleukin-2 receptor alpha 67. Interleukin-22 68. Interleukin-23 69. Interleukin-25 70. Interleukin-3 71. Interleukin-31 72. Interleukin-4 73. Interleukin-5 74. Interleukin-6 75. Interleukin-6 receptor 76. Interleukin-6 receptor subunit beta 77. Interleukin-7 78. Interleukin-8 79. Leptin 80. Lymphotactin 81. Macrophage Colony-Stimulating Factor 1 82. Macrophage inflammatory protein 3 beta 83. Macrophage Inflammatory Protein-1 alpha 84. Macrophage Inflammatory Protein-1 beta 85. Macrophage Inflammatory Protein-3 alpha 86. Macrophage Migration Inhibitory Factor 87. Macrophage-Derived Chemokine 88. Matrix Metalloproteinase-1 89. Matrix Metalloproteinase-10 90. Matrix Metalloproteinase-12 91. Matrix Metalloproteinase-2 92. Matrix Metalloproteinase-3 93. Matrix Metalloproteinase-7 94. Matrix Metalloproteinase-9 95. Matrix Metalloproteinase-9, total 96. Monocyte Chemotactic Protein 1 97. Monocyte Chemotactic Protein 2 98. Monocyte Chemotactic Protein 3 99. Monocyte Chemotactic Protein 4 100. Monokine Induced by Gamma Interferon 101. Nerve Growth Factor beta 102. Oncostatin-M 103. Osteoprotegerin 104. P-Selectin 105. Platelet-Derived Growth Factor 106. Platelet-Derived Growth Factor BB 107. Prolactin 108. Pulmonary and Activation-Regulated Chemokine 109. Receptor for advanced glycosylation end products 110. ST2 111. Stem Cell Factor 112. Stromal cell-derived factor-1 113. Stromal Cell-Derived Factor-1 alpha 114. T Lymphocyte-Secreted Protein I-309 115. T-Cell-Specific Protein RANTES 116. Thrombopoietin 117. Thymus and activation-regulated chemokine 118. Thymus-Expressed Chemokine 119. Tissue Factor 120. Tissue Inhibitor of Metalloproteinases 1 121. Tissue Inhibitor of Metalloproteinases 2 122. TNF-Related Apoptosis-Inducing Ligand Receptor 3 123. Transforming Growth Factor alpha 124. Transforming Growth Factor beta 125. Transforming Growth Factor beta-3 126. Tumor Necrosis Factor alpha 127. Tumor Necrosis Factor beta 128. Tumor necrosis factor ligand superfamily member 12 129. Tumor necrosis factor ligand superfamily member 13 130. Vascular endothelial growth factor receptor 3 131. Tumor necrosis factor receptor 2 132. Tumor Necrosis Factor Receptor I 133. Vascular Cell Adhesion Molecule-1 134. Vascular Endothelial Growth Factor 135. Vascular endothelial growth factor B 136. Vascular Endothelial Growth Factor C 137. Vascular endothelial growth factor D 138. Vascular Endothelial Growth Factor Receptor 1 139. Vascular Endothelial Growth Factor Receptor 2