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Cancer biomarkers

RBM offers numerous biomarkers associated with oncogenesis, the processes that cause normal cells to become cancerous. Our markers are useful in evaluating new therapeutics for solid tumors and blood cancers. 

 

Carcinoembryonic Antigen (CEA) and Alpha-Fetoprotein (AFP) are used as tumor markers for colorectal and liver cancers, respectively. CA-125 is a marker for ovarian cancer, while PSA is used for prostate cancer. HER2/neu is important for breast cancer prognosis and treatment decisions. BRCA1/BRCA2 mutations are associated with increased risk of breast and ovarian cancers. KRAS and EGFR mutations are relevant in colorectal and non-small cell lung cancers, guiding targeted therapies. BRAF mutations are significant in melanoma, and PD-L1 expression is a key biomarker for immunotherapy response. Ki-67 is a proliferation marker indicating tumor growth rate.

Multiplexes with cancer biomarkers

The biomarkers below have demonstrated links to solid tumors and blood cancers in the scientific literature. 

1. Interferon-inducible T-cell alpha chemoattractant 2. Interleukin-1 beta 3. Interleukin-18-binding protein 4. Interleukin-2 5. Interleukin-2 receptor alpha 6. Interleukin-23 7. Interleukin-6 8. Interleukin-6 receptor 9. Interleukin-6 receptor subunit beta 10. Interleukin-7 11. Interleukin-8 12. Kallikrein 5 13. Kallikrein-7 14. Lactoferrin 15. Lactoylglutathione lyase 16. Latency-Associated Peptide of Transforming Growth Factor beta 1 17. Leptin 18. Leucine-rich alpha-2-glycoprotein 19. Lipocalin-1 20. Lipocalin-1 21. Lumican 22. Macrophage inflammatory protein 3 beta 23. Macrophage Inflammatory Protein-1 alpha 24. Macrophage Migration Inhibitory Factor 25. Macrophage-Stimulating Protein 26. Maspin 27. Mast/stem cell growth factor receptor 28. Matrix Metalloproteinase-10 29. Matrix Metalloproteinase-2 30. Matrix Metalloproteinase-3 31. Mesothelin 32. Methylglyoxal 33. MHC class I chain-related protein A 34. Midkine 35. Monocyte Chemotactic Protein 1 36. Monocyte Chemotactic Protein 3 37. Monokine Induced by Gamma Interferon 38. Myoglobin 39. Nerve Growth Factor beta 40. Neural Cell Adhesion Molecule 1 41. Neuron-Specific Enolase 42. Neuropilin-1 43. Neutrophil Activating Peptide 2 44. Neutrophil Gelatinase-Associated Lipocalin 45. Nucleoside diphosphate kinase B 46. Oncostatin-M 47. Osteocalcin 48. Osteopontin 49. Osteoprotegerin 50. P-Selectin 51. Pancreatic Polypeptide 52. Pancreatic secretory trypsin inhibitor 53. Pepsinogen I 54. Peptidase D 55. Peptidase D 56. Peptide YY 57. Periostin 58. Peroxiredoxin-4 59. Phosphoserine Aminotransferase 60. Pigment Epithelium Derived Factor 61. Placenta Growth Factor 62. Plasminogen Activator Inhibitor 1 63. Platelet endothelial cell adhesion molecule 64. Platelet-Derived Growth Factor BB 65. Progranulin 66. Prolactin 67. Prostasin 68. Prostate Specific Antigen, total 69. Prostate-Specific Antigen, Free 70. Prostatic Acid Phosphatase 71. Protein S100-A4 72. Protein S100-A6 73. Pulmonary surfactant-associated protein D 74. Receptor tyrosine-protein kinase erbB-3 75. Resistin 76. S100 calcium-binding protein B 77. Secreted frizzled-related protein 4 78. Serum Amyloid A Protein 79. Sex Hormone-Binding Globulin 80. Squamous Cell Carcinoma Antigen-1 81. Stromal Cell-Derived Factor-1 alpha 82. Tenascin-C 83. Tenascin-X 84. Tetranectin 85. Tetranectin 86. Thrombospondin-1 87. Thrombospondin-4 88. Thyroglobulin 89. Thyroglobulin Antibody 90. Tissue Inhibitor of Metalloproteinases 2 91. Tissue type Plasminogen activator 92. TNF-Related Apoptosis-Inducing Ligand Receptor 3 93. Transforming Growth Factor alpha 94. Trefoil Factor 3 95. Tumor Necrosis Factor alpha 96. Tumor Necrosis Factor beta 97. Tumor necrosis factor ligand superfamily member 12 98. Tumor necrosis factor ligand superfamily member 13 99. Vascular endothelial growth factor receptor 3 100. Vitamin D-Binding Protein 101. Vitronectin 102. YKL-40 103. Tumor necrosis factor receptor 2 104. Tumor Necrosis Factor Receptor I 105. Tyrosine kinase with Ig and EGF homology domains 1 106. Tyrosine kinase with Ig and EGF homology domains 2 107. Urokinase-type Plasminogen Activator 108. Urokinase-type plasminogen activator receptor 109. Urokinase-type plasminogen activator receptor 110. Vascular Cell Adhesion Molecule-1 111. Vascular Endothelial Growth Factor 112. Vascular endothelial growth factor B 113. Vascular Endothelial Growth Factor C 114. Vascular endothelial growth factor D 115. Vascular Endothelial Growth Factor Receptor 1 116. Vascular Endothelial Growth Factor Receptor 2 117. 6Ckine 118. Adiponectin 119. Adrenocorticotropic Hormone 120. Aldose Reductase 121. Alpha-Fetoprotein 122. Amphiregulin 123. Angiopoietin-1 124. Angiopoietin-2 125. Angiopoietin-related protein 3 126. Annexin A1 127. Antileukoproteinase 128. Apolipoprotein A-I 129. Apolipoprotein E 130. Apolipoprotein H 131. AXL Receptor Tyrosine Kinase 132. B cell-activating factor 133. B Lymphocyte Chemoattractant 134. Bcl-2-like protein 2 135. Beta-2-Microglobulin 136. Beta-microseminoprotein 137. Betacellulin 138. Bone Morphogenetic Protein 6 139. C-Peptide 140. C-Reactive Protein 141. Cadherin-1 142. Cadherin-13 143. Calcitonin 144. Cancer Antigen 125 145. Cancer Antigen 15-3 146. Cancer Antigen 19-9 147. Cancer Antigen 72-4 148. Carbonic anhydrase 9 149. Carcinoembryonic Antigen 150. Carcinoembryonic antigen-related cell adhesion molecule 1 151. Carcinoembryonic antigen-related cell adhesion molecule 6 152. Cartilage Oligomeric Matrix Protein 153. Cathepsin B (pro) 154. Cathepsin D 155. CD 40 antigen 156. CD163 157. CD40 Ligand 158. Cellular Fibronectin 159. Chromogranin-A 160. Collagen IV 161. Complement C1q Antibody 162. Complement component C1q receptor 163. Cystatin-A 164. Cystatin-B 165. Cystatin-C 166. Decorin 167. Dickkopf-related protein 1 168. Dipeptidyl peptidase IV 169. Endoglin 170. Endostatin 171. Endothelin-1 172. Eotaxin-2 173. Epidermal Growth Factor 174. Epidermal Growth Factor Receptor 175. Epiregulin 176. Epithelial cell adhesion molecule 177. Ezrin 178. Fatty Acid-Binding Protein, adipocyte 179. Fatty Acid-Binding Protein, liver 180. Ferritin 181. Fetuin-A 182. Fibroblast growth factor 23 183. Fibroblast Growth Factor basic 184. Fibulin-1 185. Fibulin-1C 186. Fibulin-1C 187. Galanin 188. Galectin-3 189. Gelsolin 190. Glucagon 191. Glucagon 192. Glucagon-like Peptide 1, total 193. Glucose-6-phosphate Isomerase 194. Glutamate-Cysteine Ligase Regulatory subunit 195. Glutathione S-Transferase Mu 1 196. Growth-Regulated alpha protein 197. Growth/differentiation factor 15 198. HE4 199. Heat Shock Protein 60 200. Heat-Shock protein 70 201. Hemopexin 202. Heparin-Binding EGF-Like Growth Factor 203. Hepatocyte Growth Factor 204. Hepatocyte Growth Factor receptor 205. Hepsin 206. Human Chorionic Gonadotropin beta 207. Human Epidermal Growth Factor Receptor 2 208. Insulin 209. Insulin-like Growth Factor Binding Protein 4 210. Insulin-like Growth Factor Binding Protein 5 211. Insulin-like Growth Factor Binding Protein 6 212. Insulin-like Growth Factor I 213. Insulin-like Growth Factor-Binding Protein 1 214. Insulin-like Growth Factor-Binding Protein 2 215. Insulin-like Growth Factor-Binding Protein 3 216. Interferon gamma Induced Protein 10