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Cytokine and chemokine biomarkers

Cytokines and chemokines are small signaling proteins that play crucial roles in the immune system by mediating communication between cells. Cytokines, such as interleukins, interferons, and tumor necrosis factors (TNFs), regulate immune responses, inflammation, and cell proliferation. Chemokines, a subset of cytokines, are primarily involved in directing the movement of immune cells to sites of infection or injury.

RBM offers a number of cytokines and chemokines useful in assessing potential therapeutics.  For instance, cytokines can be used as therapeutic agents to boost the immune response in cancer immunotherapy or to suppress inflammation in autoimmune diseases. Additionally, blocking specific cytokines or chemokines can help treat conditions like rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Multiplexes with cytokines and chemokines

The biomarkers below include cytokines and chemokines with demonstrated links to immune and inflammatory processes in the scientific literature.
1. Interferon gamma Induced Protein 10 2. Interferon gamma Induced Protein 10, long 3. Interferon gamma Induced Protein 10, short 4. Interferon-inducible T-cell alpha chemoattractant 5. Interleukin-1 alpha 6. Interleukin-1 beta 7. Interleukin-1 receptor antagonist 8. Interleukin-10 9. Interleukin-11 10. Interleukin-12 Subunit p40 11. Interleukin-12 Subunit p70 12. Interleukin-13 13. Interleukin-15 14. Interleukin-16 15. Interleukin-17 16. Interleukin-18 17. Interleukin-18-binding protein 18. Interleukin-2 19. Interleukin-2 receptor alpha 20. Interleukin-22 21. Interleukin-23 22. Interleukin-25 23. Interleukin-3 24. Interleukin-31 25. Interleukin-4 26. Interleukin-5 27. Interleukin-6 28. Interleukin-6 receptor 29. Interleukin-6 receptor subunit beta 30. Interleukin-7 31. Interleukin-8 32. Leptin 33. Lymphotactin 34. Macrophage Colony-Stimulating Factor 1 35. Macrophage inflammatory protein 3 beta 36. Macrophage Inflammatory Protein-1 alpha 37. Macrophage Inflammatory Protein-1 beta 38. Macrophage Inflammatory Protein-3 alpha 39. Macrophage Migration Inhibitory Factor 40. Macrophage-Derived Chemokine 41. Matrix Metalloproteinase-1 42. Matrix Metalloproteinase-10 43. Matrix Metalloproteinase-12 44. Matrix Metalloproteinase-2 45. Matrix Metalloproteinase-3 46. Matrix Metalloproteinase-7 47. Matrix Metalloproteinase-9 48. Matrix Metalloproteinase-9, total 49. Monocyte Chemotactic Protein 1 50. Monocyte Chemotactic Protein 2 51. Monocyte Chemotactic Protein 3 52. Monocyte Chemotactic Protein 4 53. Monokine Induced by Gamma Interferon 54. Nerve Growth Factor beta 55. Oncostatin-M 56. Osteoprotegerin 57. P-Selectin 58. Platelet-Derived Growth Factor 59. Platelet-Derived Growth Factor BB 60. Prolactin 61. Pulmonary and Activation-Regulated Chemokine 62. Receptor for advanced glycosylation end products 63. ST2 64. Stem Cell Factor 65. Stromal cell-derived factor-1 66. Stromal Cell-Derived Factor-1 alpha 67. T Lymphocyte-Secreted Protein I-309 68. T-Cell-Specific Protein RANTES 69. Thrombopoietin 70. Thymus and activation-regulated chemokine 71. Thymus-Expressed Chemokine 72. Tissue Factor 73. Tissue Inhibitor of Metalloproteinases 1 74. Tissue Inhibitor of Metalloproteinases 2 75. TNF-Related Apoptosis-Inducing Ligand Receptor 3 76. Transforming Growth Factor alpha 77. Transforming Growth Factor beta 78. Transforming Growth Factor beta-3 79. Tumor Necrosis Factor alpha 80. Tumor Necrosis Factor beta 81. Tumor necrosis factor ligand superfamily member 12 82. Tumor necrosis factor ligand superfamily member 13 83. Vascular endothelial growth factor receptor 3 84. Tumor necrosis factor receptor 2 85. Tumor Necrosis Factor Receptor I 86. Vascular Cell Adhesion Molecule-1 87. Vascular Endothelial Growth Factor 88. Vascular endothelial growth factor B 89. Vascular Endothelial Growth Factor C 90. Vascular endothelial growth factor D 91. Vascular Endothelial Growth Factor Receptor 1 92. Vascular Endothelial Growth Factor Receptor 2 93. 6Ckine 94. Adiponectin 95. Agouti-Related Protein 96. Amphiregulin 97. Angiogenin 98. Angiopoietin-1 99. Angiopoietin-2 100. AXL Receptor Tyrosine Kinase 101. B cell-activating factor 102. B Lymphocyte Chemoattractant 103. Betacellulin 104. Bone Morphogenetic Protein 6 105. Brain-Derived Neurotrophic Factor 106. Cadherin-1 107. CD40 Ligand 108. CD5 Antigen-like 109. Chemokine CC-4 110. Ciliary Neurotrophic Factor 111. E-Selectin 112. EN-RAGE 113. Endostatin 114. Eotaxin-1 115. Eotaxin-2 116. Eotaxin-3 117. Epidermal Growth Factor 118. Epidermal Growth Factor Receptor 119. Epithelial-Derived Neutrophil-Activating Protein 78 120. Fas Ligand 121. FASLG Receptor 122. Fibroblast Growth Factor 4 123. Fibroblast Growth Factor basic 124. Glucose-6-phosphate Isomerase 125. Granulocyte Colony-Stimulating Factor 126. Granulocyte-Macrophage Colony-Stimulating Factor 127. Growth-Regulated alpha protein 128. Hepatocyte Growth Factor 129. Hepatocyte Growth Factor receptor 130. Insulin-like Growth Factor Binding Protein 4 131. Insulin-like Growth Factor Binding Protein 5 132. Insulin-like Growth Factor Binding Protein 6 133. Insulin-like Growth Factor I 134. Insulin-like Growth Factor II 135. Insulin-like Growth Factor-Binding Protein 1 136. Insulin-like Growth Factor-Binding Protein 2 137. Insulin-like Growth Factor-Binding Protein 3 138. Intercellular Adhesion Molecule 1 139. Interferon gamma