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Cardiovascular biomarkers

RBM offers dozens of biomarkers that are correlated to a variety of cardiovascular conditions, including coronary artery disease (CAD), cerebrovascular disease (stroke), cardiomyopathy, congestive heart failure, acute coronary syndrome, and atherosclerosis.

 

While a diverse set of mechanisms contribute to cardiovascular disease (CVD), inflammatory and metabolic pathways often contribute to hallmark symptoms including hypoxia, artery thickening, blood vessel damage, and the resulting heart muscle damage.

 

In addition, people with diabetes and certain inflammatory conditions are often found to have cardiovascular risk factors, such as high blood pressure and elevated cholesterol. Our biomarkers reflect various aspects of cardiovascular health, including inflammation, endothelial function, lipid metabolism, and plaque stability. These biomarkers can help evaluate potential therapeutics for a variety of CVD conditions.

Cardiovascular-associated multiplexes

The biomarkers below have demonstrated links to cardiovascular disease in the scientific literature.
1. Adiponectin 2. Angiopoietin-1 3. Angiopoietin-2 4. Angiopoietin-related protein 3 5. Angiotensin-Converting Enzyme 6. Angiotensinogen 7. Antithrombin-III 8. Apolipoprotein A-I 9. Apolipoprotein A-II 10. Apolipoprotein B 11. Apolipoprotein C-III 12. Apolipoprotein E 13. Apolipoprotein H 14. Apolipoprotein(a) 15. C-Reactive Protein 16. Carcinoembryonic antigen-related cell adhesion molecule 1 17. CD163 18. Complement C3 alpha des arg 19. Connective Tissue Growth Factor 20. Creatine Kinase-MB 21. Cystatin-C 22. Endoglin 23. Endostatin 24. Endothelin-1 25. Epiregulin 26. Factor VII 27. Fatty Acid-Binding Protein, adipocyte 28. Fatty Acid-Binding Protein, liver 29. Fibrinogen 30. Fibroblast Growth Factor 4 31. Fibroblast Growth Factor basic 32. Galectin-3 33. Gelsolin 34. Glucose-6-phosphate Isomerase 35. Glutamate-Cysteine Ligase Regulatory subunit 36. Glycogen phosphorylase isoenzyme BB 37. Granulocyte Colony-Stimulating Factor 38. Growth-Regulated alpha protein 39. Growth/differentiation factor 15 40. Haptoglobin 41. Heparin-Binding EGF-Like Growth Factor 42. Intercellular Adhesion Molecule 1 43. Interferon gamma 44. Interferon gamma Induced Protein 10 45. Interleukin-1 alpha 46. Interleukin-1 beta 47. Interleukin-10 48. Interleukin-18 49. Interleukin-6 50. Interleukin-6 receptor 51. Interleukin-8 52. Lectin-Like Oxidized LDL Receptor 1 53. Leptin 54. Low Density Lipoprotein Cholesterol 55. Macrophage-Derived Chemokine 56. Malondialdehyde-Modified Low-Density Lipoprotein 57. Matrix Metalloproteinase-2 58. Matrix Metalloproteinase-3 59. Matrix Metalloproteinase-9 60. Methylglyoxal 61. Monocyte Chemotactic Protein 1 62. Myeloperoxidase 63. Myoglobin 64. N-terminal prohormone of brain natriuretic peptide 65. Nerve Growth Factor beta 66. Neuropilin-1 67. Osteopontin 68. Osteoprotegerin 69. Paraoxonase-1 70. Pigment Epithelium Derived Factor 71. Placenta Growth Factor 72. Plasminogen Activator Inhibitor 1 73. Platelet endothelial cell adhesion molecule 74. Platelet-Derived Growth Factor BB 75. Pregnancy-Associated Plasma Protein A 76. Pulmonary and Activation-Regulated Chemokine 77. Receptor for advanced glycosylation end products 78. Serotransferrin 79. Serum Amyloid A Protein 80. Serum Amyloid P-Component 81. Serum Glutamic Oxaloacetic Transaminase 82. Sex Hormone-Binding Globulin 83. Sortilin 84. ST2 85. Stromal Cell-Derived Factor-1 alpha 86. Thrombomodulin 87. Thrombospondin-1 88. Tissue Factor 89. Tissue Inhibitor of Metalloproteinases 1 90. Tissue Inhibitor of Metalloproteinases 2 91. Tissue type Plasminogen activator 92. Tumor Necrosis Factor alpha 93. Tumor necrosis factor ligand superfamily member 12 94. Tumor necrosis factor ligand superfamily member 13 95. Vascular endothelial growth factor receptor 3 96. Vitamin K-Dependent Protein S 97. von Willebrand Factor 98. Tyrosine kinase with Ig and EGF homology domains 1 99. Tyrosine kinase with Ig and EGF homology domains 2 100. Vascular Cell Adhesion Molecule-1 101. Vascular Endothelial Growth Factor 102. Vascular endothelial growth factor B 103. Vascular Endothelial Growth Factor C 104. Vascular endothelial growth factor D 105. Vascular Endothelial Growth Factor Receptor 1 106. Vascular Endothelial Growth Factor Receptor 2