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Vascular Endothelial Growth Factor

Vascular Endothelial Growth Factor

Vascular Endothelial Growth Factor (VEGF) is an integral growth factor that is active in angiogenesis, vasculogenesis, and endothelial cell growth. It induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. It binds primarily to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate, and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. The isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, nor does it activate angiogenesis or inhibit tumor growth. VEGF is important in the pathophysiology of neuronal and other tumors, probably functioning as a potent promoter of angiogenesis. It is also involved with altering blood-brain-barrier functions under normal and pathological conditions. VEGF secreted from the stromal cells may be responsible for the endothelial cell proliferation in capillary hemangioblastomas which are composed of abundant microvasculature and primitive angiogenic elements represented by stromal cells. VEGF expression is regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia, and oncogenic mutations.

Swiss-Prot Accession Number: P15692


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Correlative serum biomarker analyses in the phase 2 trial of lenvatinib-plus-everolimus in patients with metastatic renal cell carcinoma (2021) Lee CH, Motzer RJ, Glen H, Michaelson MD, Larkin J, Minoshima Y, Kanekiyo M, Ikezawa H, Sachdev P, Dutcus CE, Funashashi Y, Voss MH British Journal of Cancer

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Characterization of Renal Biomarkers for Use in Clinical Trials: Effect of Preanalytical Processing and Qualification Using Samples from Subjects with Diabetes (2015) Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N Drug Design, Development and Therapy

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A multi-biomarker disease activity score tracks clinical response consistently in patients with rheumatoid arthritis treated with different anti-tumor necrosis factor therapies: A retrospective observational study (2014) Hirata S, Li W, Defranoux N, Cavet G, Bolce R, Yamaoka K, Saito K & Tanaka Y Mod Rheumatol.

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Multiplexed protein profiling after aneurysmal subarachnoid hemorrhage: Characterization of differential expression patterns in cerebral vasospasm. (2014) Walcott BP, Patel AP, Stapleton CJ, Trivedi RA, Young AM, Ogilvy CS. J Clin Neurosci. 2014 Jul 28. pii: S0967-5868(14)00318-X. doi: 10.1016/j.jocn.2014.06.004. [Epub ahead of print]

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A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study (2013) Hirata S, Dirven L, Shen Y, Centola M, Cavet G, Lems WF, Tanaka Y, Huizinga WJ and Allaart CF Rheumatology

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Impact of Sunitinib on Human Thyroid Cancer Cells (2013) Grosse J, Warnke E, Pohl F, Magnusson NE, Wehland M, Infanger M, Eilles C, Grimm D Cell Physiol Biochem. 2013 Jul 12;32(1):154-170

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Prognostic/predictive value of 207 serum factors in colorectal cancer treated with cediranib and/or chemotherapy (2013) Spencer SK, Pommier AJ, Morgan SR, Barry ST, Robertson JD, Hoff PM, J?rgensmeier JM Br J Cancer. 2013 Oct 22

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Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space (2013) Ma X, Pietsch J, Wehland M, Schulz H, Saar K, H?bner N, Bauer J, Braun M, Schwarzw?lder A, Segerer J, Birlem M, Horn A, Hemmersbach R, Wa?er K, Grosse J, Infanger M, Grimm D FASEB J. 2013 Nov 6. [Epub ahead of print]

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Identification of Subgroups of Schizophrenia Patients with Changes in Either Immune or Growth Factor and Hormonal Pathways (2013) Schwarz E, Van Beveren NJM, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S Schizophrenia Bulletin

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Inflammatory Mediator Profiling Reveals Immune Properties of Chemotactic Gradients and Macrophage Mediator Production Inhibition During Thioglycollate Elicited Peritoneal Inflammation (2013) Lam D, Harris D, Qin Z Mediators of Inflammation

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The effects of vitamin A on cells of innate immunity in vitro (2013) Wojtal K, Wolfram L, Frey-Wagner I, Lang S, Scharl M, Vavricka SR, Rogler G Toxicology in Vitro,

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Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study (2013) Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T BMC Neurol. 2013 Apr 8;13(1):32

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Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator (2013) Patel OV, Wilson WB, Qin Z BioMetals, April 2013

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Characterization of a multiplex, 12-biomarker test for rheumatoid arthritis (2012) Eastman P.S, Manning WC, Qureshi F, Haney D, Cavet G, Alexander C, Hesterberg LK Pharm Biomed Anal.

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Validation of a Novel Multibiomarker Test to Assess Rheumatoid Arthritis Disease Activity (2012) Curtis Jr, van der Helm-van Mil ah, Knevel R, Huizinga TW, Haney DJ, Shen Y, Ramanujan S, Cavet G, Centola M, Hesterberg LK, Chernoff D, Ford K, Shadick N, Hamburger M, Fleischmann R, Keystone E, and Weinblatt ME Arthritis Care & Res.

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Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study (2012) Bakker MF, Cavet G, Jacobs J, Bijlsma J, Haney DJ, Shen Y, Hesterberg LK, Smith D, Centola M, van Roon J, Lafeber F, Welsing P Ann Rheum Dis.

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Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis (2012) Zhao X, Qureshi F, Eastman P.S, Manning WC, Alexander C, Robinson WH, Hesterberg LK J Immunol Methods

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Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia (2012) Pedroso FE, Spalding PB, Cheung MC, Yang R, Gutierrez JC, Bonetto A, Zhan R, Chan HL, Namias N, Koniaris LG, Zimmers TA J Cachexia Sarcopenia Muscle. 2012 Mar 29

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Interleukin-7 aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation (2012) Hartgring SA, Willis CR, Bijlsma JW, Lafeber FP, van Roon JA Arthritis Res Ther. 2012 Jun 7;14(3):R137

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Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index (2012) Wang P, Holst C, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WK, Andersen MR, van Baak MA, Rasmussen LG, Martinez JA, Jebb SA, Pfeiffer AF, Kafatos A, Handjieva-Darlenska T, Hlavaty P, Saris WH, Mariman EC Br J Nutr. 2012 Jan;107(1):106-19

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Molecular Markers for Diagnosis of Periprosthetic Joint Infection (2011) Jacovides CL, Parvizi J, Adeli B, Jung KA J Arthroplasty. 2011 May 12. [Epub ahead of print]

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Bone Marrow Derived Mesenchymal Stromal Cells are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth In Vitro and In Vivo (2011) Xu S, Menu E, De Becker A, Van Camp B, Vanderkerken K, Van Riet I Stem Cells. 2011 Nov 18. [Epub ahead of print]

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Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant (2011) Ghosn CR, Li Y, Orilla WC, Lin T, Wheeler L, Burke JA, Robinson MR, Whitcup SM Invest Ophthalmol Vis Sci. 2011 May 2;52(6):2917-23

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Bevacizumab therapy normalizes the pathological intraocular environment beyond neutralizing VEGF (2010) Sharma RK, Rogojina AT, Chalam KV Mol Vi. 16: 2175-2184.

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Urinary clusterin, cystatin C, ?2-microglobulin and total protein as markers to detect drug-induced kidney injury (2010) Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedtler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G Nat Biotechnol 28: 463-469.

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Identification of distinct plasma biomarker signatures in patients with rapid and slow declining forms of COPD (2010) Devanarayan V, Scholand MB, Hoidal J, Leppert MF, Crackower MA, ONeill GP, Gervais FG COPD 7: 51-58.

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Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis (2009) Kirby PJ, Shines CJ, Taylor GJ, Bousquet RW, Price HC, Everitt JI, Morgan DL Exp Lung Res. 2009 Dec;35(10):858-82

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Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice (2009) Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, Hamelmann E, Schulz H, Stoeger T Part Fibre Toxicol. 6: 31.

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Heart Failure Therapy Mediated by the Trophic Activities of Bone Marrow Mesenchymal Stem Cells: A Non-invasive Therapeutic Regimen. (2009) Shabbir A, Zisa D, Suzuki G, Lee T Am J Physiol Heart Circ Physiol 296: H1888-H1897.

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The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis - a mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide. (2009) Steger-Hartmann T, Raschke M, Riefke B, Pietsch H, Sieber MA, Walter J Exp Toxicol Pathol 61: 537-552.

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Multiplex Immunoassay Analysis of Biomarkers in Clinically Accessible Quantities of Human Aqueous Humor. (2009) Sharma RK, Rogojina AT, Chalam KV Mol Vis 15: 60-69.

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The Link Between Heightened Thrombogenicity and Inflammation: Pre-Procedure Characterization of the Patient at High Risk for Recurrent Events After Stenting. (2009) Gurbel PA, Bliden KP, Kreutz RP, Dichiara J, Antonino MJ, Tantry US Platelets 20: 97-104.

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Perturbation of mouse retinal vascular morphogenesis by anthrax lethal toxin (2009) Bromberg-White JL, Boguslawski E, Duesbery NS PLoS ONE 4: e6956.

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Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects. (2008) Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou-El-Ardat K, Ghardi M, Arlette M, Baatout S Dev Biol 322: 302-313.

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Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma. (2008) Ding Y, Boguslawski EA, Berghuis BD, Young JJ, Zhang Z, Hardy K, Furge K, Kort E, Frankel AE, Hay RV, Resau JH, Duesbery NS Mol Cancer Ther 7: 648-658.

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Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer. (2008) Oh Y, Herbst RS, Burris H, Cleverly A, Musib L, Lahn M, Bepler G J Clin Oncol 26: 1135-1141.

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Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice. (2008) Cuaz-P?rolin C, Billiet L, Baug? E, Copin C, Scott-Algara D, Genze F, B?chele B, Syrovets T, Simmet T, Rouis M Arterioscler Thromb Vasc Biol 28: 272-277.

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Modeled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells. (2007) Infanger M, Ulbrich C, Baatout S, Wehland M, Kreutz R, Bauer J, Grosse J, Vadrucci S, Cogoli A, Derradji H, Neefs M, K?sters S, Spain M, Paul M, Grimm D J Cell Biochem 101: 1439-1455.

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Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1+/- mice. (2007) Basi DL, Adhikari N, Mariash A, Li Q, Kao E, Mullegama SV, Hall JL Am J Physiol Heart Circ Physiol 292: H516-H521.

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Murine embryonic stem cells secrete cytokines/growth modulators that enhance cell survival/anti-apoptosis and stimulate colony formation of murine hematopoietic progenitor cells. (2006) Guo Y, Graham-Evans B, Broxmeyer HE Stem Cells 24: 850-856.

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