TNF-Related Apoptosis-Inducing Ligand Receptor 3

Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor 3 (TRAIL-R3) is also called DcR1 (decoy receptor 1). In the new TNF nomenclature, TRAIL-R3 is referred to as TNFRSF10C. TRAIL-R3 lacks the TRAIL intracellular signaling domain, thus the binding of TRAIL to TRAIL-R3 does not transduce an apoptosis signal. TRAIL-R3 may protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Swiss-Prot Accession Number: O14798

Bibliography

Novel CSF biomarkers for frontotemporal lobar degenerations (2010) Hu WT, Chen-Plotkin A, Grossman M, Arnold SE, Clark CM, Shaw LM, McCluskey L, Elman L, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ Neurology 75: 2079-86.

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TNF-Related Apoptosis-Inducing Ligand Receptor 3