Tumor necrosis factor receptor 2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor 2 (TNFR2) is a soluble form of the TNF receptor. Two types of soluble TNF receptors have been identified in human serum and urine that neutralize the biological activities of TNF-alpha and TNF-beta. These binding proteins represent truncated forms of the two types of high-affinity cell surface receptors for TNF (TNFR-p60 Type B and TNFR-p80 Type A). Soluble TNF RI corresponds to TNFR-p60 Type B. Soluble TNF RII corresponds to TNFR-p80 Type A. In the TNF superfamily nomenclature, TNFR1 and TNFR2 are referred to as TNFRSF1A and TNFRSF1B, respectively. These apparent soluble forms of the receptors appear to arise as a result of shedding of the extracellular domains of the membrane-bound receptors.
Swiss-Prot Accession Number: P20333
Bibliography
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