Thrombomodulin

Thrombomodulin (TM), also known as CD141, is an integral membrane protein expressed on the surface of endothelial cells. It functions as a cofactor in the thrombin-induced activation of protein C by forming a 1:1 complex with thrombin. This complex stimulates fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor (TAFI) into its active form. Increased serum levels of thrombomodulin have been associated with smoking, cardiac surgery, atherosclerosis, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis.

Swiss-Prot Accession Number: P07204