Tyrosine kinase with Ig and EGF homology domains 2 (TIE-2) is a receptor tyrosine kinase that is expressed primarily on endothelial cells and plays a critical role in vascular development. The ligands for TIE-2 include angiopoietins (Ang) -1, -2, -3 and -4. Soluble TIE-2 plays a role in angiogenesis.
Swiss-Prot Accession Number: Q02763
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