Microtubule-Associated Protein Tau Simoa

Tau is a neuronal microtubule associated protein found mostly on axons. Tau functions to stabilize microtubules and promote tubule polymerization. Tau contains multiple phosphorylation sites and can be phosphorylated by a number of kinases, including GSK3, CDK5, and PKA. In its hyperphosphorylated state, tau is the major component of paired helical filaments which are the building block of neurofibrillary lesions in Alzheimer?s Disease. Hyperphosphorylation impairs tau?s ability to bind and stabilize microtubules leading to the degeneration of the affected neurons.

Swiss-Prot Accession Number: P10636