Transmembrane activator and CAML interactor Simoa

The transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily, member 13b (TNFRSF13B), acts as a cell membrane receptor that can bind and transduce the B-cell activating signals of APRIL and BAFF. TACI activation of B cells leads to their differentiation and maturation, including antibody isotype switch, and T cell-independent antibody production. Mutations in TACI have been found in 8-10% of patients with common variable immunodeficiency (CVID) suggesting a role for these mutations in the development of low serum immunoglobulins and lack of antibody characteristic of this disorder. TACI is a binding partner of calcium-modulator and cyclophilin ligand (CAML) protein in Jurkat T cells and functions as a co-inducer of nuclear factor of activated T cells (NF-AT) transcription factor. Cross-linking of TACI by anti-TACI antibodies also leads to the activation of transcription factors AP-1 and NF-kB. Through interactions with other proteins, TACI promotes cell signaling, plays a role in B cell survival and maturation, and is involved in the production of antibodies.

Swiss-Prot Accession Number: O14836