Synaptosomal-associated protein 25 Simoa

SNAP25 is a Q-SNARE protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans. It is involved in the molecular regulation of neurotransmitter release and may play an important role in the synaptic function of specific neuronal systems. It associates with proteins involved in vesicle docking and membrane fusion and regulates plasma membrane recycling through its interaction with CENPF. It also modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. SNAP25 is anchored to the cytosolic face of membranes via palmitoyl side chains covalently bound to cysteine amino acid residues in the central linker domain of the molecule and therefore does not contain a trans-membrane domain. SNAP25 has been used to study attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder.

Swiss-Prot Accession Number: P60880