Phospho-Tau217 Simoa

Smoking changes adaptive immunity with persistent effects (2024) Violaine Saint-Andr?, Bruno Charbit3, Anne Biton, Vincent Rouilly, C?line Poss?m?, Anthony Bertrand, Maxime Rotival, Jacob Bergstedt, Etienne Patin, Matthew L. Albert, Lluis Quintana-Murci, Darragh Duffy Nature

Interferon-Gamma-Release assay and absolute CD8 lymphocyte count for acquired immunosuppression monitoring in critically ill patients (2024) Muzhda Haem Rahimi, Fabienne Venet, Anne-Claire Lukaszewicz, Estelle Peronnet, Elisabeth Cerrato, Thomas Rimmel?, Guillaume Monneret Cytokine

A Human Whole Blood Culture System Reveals Detailed Cytokine Release Profiles of Implant Materials (2024) Sascha Niclas Klimosch, Marbod Weber, Jordi Caball?-Serrano, Thomas Knorpp, Antonio Munar-Frau, Birgit Margareta Schaefer, Manfred Schmolz Medical Devices: Evidence and Research

Whole blood stimulation provides preliminary evidence of altered immune function following SRC (2024) Alex P. Di Battista, Shawn G. Rhind, Maria Shiu and Michael G. Hutchison BMC Immunology

An Exploratory Study of Early Immune Response Markers for Pembrolizumab in Urothelial Tract Cancer (2024) Dag Rune Stormoen ,Lise H?j Omland,Kent William Mouw,Zoltan Szallasi,Sisse Rye Ostrowski, Susanne Dam Nielsen and Helle Pappot Uro

Cedirogant Population Pharmacokinetics and Pharmacodynamic Analyses of Interleukin-17A Inhibition in Two Phase I Studies in Healthy Participants and Participants with Moderate to Severe Psoriasis (2024) Corinna S Maier, Doerthe Eckert, F Stephen Laroux, Kinjal M Hew, Ahmed A Suleiman, Wei Liu, Mohamed-Eslam F Mohamed Clin Pharmacol Drug Dev

Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer-Results of the prospective multicenter PERMAD trial (2024) Thomas Seufferlein, Ludwig Lausser, Alexander Stein, Dirk Arnold, Gerald Prager, Stefan Kasper-Virchow, Michael Niedermeier, Lothar M?ller, Stefan Kubicka, Alexander K?nig, Petra B?chner-Steudel, Kai Wille, Andreas W Berger, Angelika M R Kestler, Johann M Kraus, Silke D Werle, Lukas Perkhofer, Thomas J Ettrich, Hans A Kestler Plos One

Proteomic Biomarkers for the Prediction of Transition to Psychosis in Individuals at Clinical High Risk: A Multi-cohort Model Development Study (2024) Jonah F. Byrne, Colm Healy, Melanie F?cking, Subash Raj Susai, David Mongan, Kieran Wynne, Eleftheria Kodosaki, Meike Heurich, Lieuwe de Haan, Ian B. Hickie, Stefan Smesny, Andrew Thompson, Connie Markulev, Alison Ruth Young, Miriam R. Sch?fer, Anita Riecher-R?ssler, Nilufar Mossaheb, Gregor Berger, Monika Schl?gelhofer, Merete Nordentoft, Eric Y.H. Chen, Swapna Verma, Dorien H. Nieman, Scott W. Woods, Barbara A. Cornblatt, William S. Stone, Daniel H. Mathalon, Carrie E. Bearden, Kristin S. Cadenhead, Jean Addington, Elaine F. Walker, Tyrone D. Cannon, Mary Cannon, Pat McGorry, Paul Amminger, Gerard Cagney, Barnaby Nelson, Clark Jeffries, Diana Perkins, and David R. Cotter Schizophrenia Bulletin

Betaine and L-Carnitine Synergistically Influence the Metabolome and Immune Response in Dogs (2024) Dennis E. Jewell, Selena K. Tavener, Renea Creech and Kiran S. Panickar Animals

Plant stanol consumption increases anti-COVID-19 antibody responses, independent of changes in serum cholesterol concentrations: a randomized controlled trial (2024) Lieve van Brakel, Ronald P Mensink, Dieter L?tjohann, Jogchum Plat The Americal Journal of Clinical Nutrition

Whole-blood culture-derived cytokine combinations for the diagnosis of tuberculosis (2024) Anne Ahrens ?stergaard, S?ren Feddersen, Mike B. Barnkob, Rasmus Bank Lynggaard, Amanda Cecilie Annie Karstoft, Maria Borup, Ingrid Louise Titlestad, Torben Tranborg Jensen, Ole Hilberg, Christian Wejse, Stephanie Bjerrum, Morten Blaabjerg, Kristian Assing, Isik Somuncu Johansen Frontiers in Immunology

Immune cell populations and induced immune responses at admission in patients hospitalized with vaccine breakthrough SARS-CoV-2 infections (2024) Adin Sejdic, Hans Jakob Hartling, Jon Gitz Holler, Lars Klingen Gj?rde 4, Birgitte Lindegaard, Arnold Matovu Dungu, Filip Gnesin, Maria Elizabeth Engel M?ller, Rebecca Svanberg Teglgaard, Carsten Utoft Niemann, Patrick Terrence Brooks, Charlotte Sv?rke J?rgensen, Kristina Tr?holt Franck, Thea K Fischer, Hanne Vibeke Marquart, Zitta Barrella Harboe, Sisse Rye Ostrowski Frontiers in Immunology

Low testosterone levels relate to poorer cognitive function in women in an APOE-e4-dependant manner (2024) Melanie A Dratva, Sarah J Banks, Matthew S Panizzon, Douglas Galasko, Erin E Sundermann Biology of Sex Differences

A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome (2024) Terese C. Hammond, Marco A. Purbhoo, Sapana Kadel, Jerome Ritz, Sarah Nikiforow4, Heather Daley, Kit Shaw, Koen van Besien, Alexandra Gomez-Arteaga, Don Stevens, WaldoOrtuzar, Xavier Michelet, Rachel Smith, Darrian Moskowitz, Reed Masakayan, Burcu Yigit, Shannon Boi, Kah Teong Soh, John Chamberland, Xin Song, Yu Qin, Ilya Mishchenko, Maurice Kirby, Valeriia Nasonenko, Alexa Buffa, Jennifer S. Buell, Dhan Chand, Marc van Dijk, Justin Stebbing & Mark A. Exley Nature Communications

Urinary markers differentially associate with kidney inflammatory activity and chronicity measures in patients with lupus nephritis (2023) Ahmad Akhgar, Dominic Sinibaldi, Lingmin Zeng, Alton B Farris III, Jason Cobb, Monica Battle, David Chain, Jennifer A Cann, Gabor G Illei, S Sam Lim , Wendy I White Lupis Science and Medicine

Early and recent exposure to adversity, TLR-4 stimulated inflammation, and diurnal cortisol in women with interstitial cystitis/bladder pain syndrome: A MAPP research network study (2023) Susan K Lutgendorf, Sharaf Zia, Yi Luo, Michael ODonnell, Adrie van Bokhoven, Catherine S Bradley, Robert Gallup, Jennifer Pierce, Bayley J Taple, Bruce D Naliboff, J Quentin Clemens, Karl J Kreder, Andrew Schrepf Brain, Behavior, and Immunity

Target occupancy biomarker assay development using a conformation-selective antibody against small-molecule-bound TNF (2023) Elizabeth S Hickford, James O?Connell , Alison Maloney, Peter Florian, Geoffrey I Bioanalysis

Regorafenib plus nivolumab in patients with mismatch repair-proficient/microsatellite stable metastatic colorectal cancer: a single-arm, open-label, multicentre phase 2 study (2023) Marwan Fakih, Kanwal Pratap Singh Raghav, David Z. Chang, Tim Larson, Allen L. Cohn, Timothy K. Huyck, David Cosgrove, Joseph A. Fiorillo, Rachel Tam, David D?Adamo, Neelesh Sharma, Barbara J. Brennan, Ying A. Wang,k Sabine Coppieters, Hong Zebger-Gong, Anke Weispfenning,m Henrik Seidel, Bart A. Ploeger,m Udo Mueller, Carolina Soares Viana de Oliveira, and Andrew Scott Paulsono eClinicalMedicine

First-in-human study of E7130 (a tumor microenvironment-ameliorating microtubule inhibitor) in patients with advanced solid tumors: Primary results of the dose-escalation part (2023) Toshihiko Doi MD, PhD, Nobuaki Matsubara MD, Yoichi Naito MD, Yasutoshi Kuboki MD, Kenichi Harano MD, Makiko Ono MD, PhD, Tetsuya Urasaki MD, PhD, Akihiro Ohmoto MD, PhD, Tsubasa Kawanai MSc, Takashi Hisai MSc, Hiroki Ikezawa MSc, Sari Shiba MSc, Ken Ito PhD, Taro Semba MSc, Osamu Asano PhD, Shunji Takahashi MD, PhD Cancer

Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline (2023) Neel H. Mehta, Liangdong Zhou, Yi Li, Laura Beth McIntire, Anna Nordvig, Tracy Butler, Mony de Leon & Gloria C. Chiang Nature

Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers?In cognitively unimpaired older adults (2023) Elettra Capogna, Leiv Otto Watne, ?ystein S?rensen, Carlijn Jamila Guichelaar, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Pi?eiro Brain Behavior Immunology

Long-term in vivo vitamin D3 supplementation modulates bovine IL-1 and chemokine responses (2023) Cian Reid , Susana Flores-Villalva, Aude Remot, Emer Kennedy, Cliona O?Farrelly Nature

Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder (2023) Kasper Recourt, Peter de Boer, Peter van der Ark, Heike Benes, Joop M A van Gerven, Marc Ceusters, Luc van Nueten, Wayne C Drevets, Anindya Bhatacharya, Michael Browning, Gabriel E Jacobs Translational Psychiatry

Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk: A 2-Sample Mendelian Randomization Study (2023) Tushar Sood, Nicolas Perrot, Michael Chong, Pedrum Mohammadi-Shemirani, Maha Mushtaha, Darryl Leong, Sumathy Rangarajan, Sibylle Hess, Salim Yusuf, Hertzel C Gerstein, Guillaume Par?, Marie Pigeyre JAMA Network

Tezepelumab Efficacy in Patients with Severe, Uncontrolled Asthma with Comorbid Nasal Polyps in NAVIGATOR (2023) Tanya M Laidlaw, Andrew Menzies-Gow, Scott Caveney, Joseph K Han, Nicole Journal of Asthma and Allergy

Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP-1 (2023) Jennifer Leohr and Maria C. Kjellsson CPT: Pharmacometrics & Systems Pharmacology

Clinical and Prognostic Biomarker Value of Blood-Circulating Inflammatory Cytokines in Hepatocellular Carcinoma (2023) Shadi Chamseddine, Yehia I. Mohamed, Sunyoung S. Lee, James C. Yao, Clinical Translational Research

Levels of iron and iron-related proteins in Alzheimers disease: a systematic review and meta-analysis (2023) Lin Gong, Jiahui Sun, Shuyan Cong Journal of Trace Elements in Medicine and Biology

Identification of molecular subphenotypes in two cohorts of paediatric ARDS (2023) Nadir Yehya , Matt S Zinter , Jill M Thompson, Michelle J Lim, Mark R Hanudel, Mustafa F Alkhouli, Hector Wong, Matthew N Alder,Daniel J McKeone, E Scott Halstead, Pratik Sinha, Anil Sapru5 Thorax

Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase 1b Trial (2023) Steffan T. Nawrocki, Julian Olea, Claudia Villa Celi, Homa Dadrastoussi,Kaijin Wu, Denice Tsao-Wei, Anthony Colombo, Matt Coffey, Eduardo Fernandez Hernandez, Xuelian Chen, Gerard J. Nuovo, Jennifer S. Carew, Ann F. Mohrbacher, Paul Fields, Peter Kuhn, Imran Siddiqi, Akil Merchant, and Kevin R. Kelly Clinical Cancer Research

Identification of an APOE e4?specific blood-based molecular pathway for Alzheimers disease risk (2023) Qiushan TaoMD, Chao Zhang PhD, Gustavo MercierMD, PhD, Kathryn Lunetta, Ting Fang Alvin AngMD, Samia Akhter-Khan MS Zhengrong Zhang PhD, Andrew Taylor PhD, Ronald J. Killiany PhD, Alzheimer?s & Dementia: Diagnosis, Assessment & DiseaseMonitoring

Effect of anterior quadratus lumborum block with ropivacaine on the immune response after laparoscopic surgery in colon cancer: a substudy of a randomized clinical (2023) Lukas Balsevicius, Paulo C M Urbano, Rune Petring Hasselager, Ahmed Abdirahman Mohamud, Maria Olausson, Melina Svraka, Kirsten L Wahlstr?m, Carolin Oppermann, Dilara Seyma G?genur, Emma Rosenkrantz H?lmich, Britt Cappelen, Susanne Gj?rup S?kmose, Katrine Tanggaard, Thomas Litman, Jens B?rglum, Susanne Brix, Ismail G?genur Reg Anesth Pain Med

Sex hormone-binding globulin and heart failure hospitalizations in patients with dysglycemia Experiences from the Outcome Reduction with an Initial Glargine (2023) Anne Wang, Sibylle Hess, Shun Fu Lee, Hertzel C. Gerstein Diabetes Res Clin Pract

IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial (2023) Lindsay Ackerman, Gerard Acloque, Sandro Bacchelli, Howard Schwartz, Brian J. Feinstein, Phillip La Stella, Afsaneh Alavi, Ashwin Gollerkeri, Jeffrey Davis, Veronica Campbell, Alice McDonald, Sagar Agarwal, Rahul Karnik, Kelvin Shi, Aimee Mishkin, Jennifer Culbertson, Christine Klaus, Bradley Enerson, Virginia Massa, Eric Kuhn, Kirti Sharma, Erin Keaney, Randy Barnes, Dapeng Chen, Xiaozhang Zheng, Haojing Rong, Vijay Sabesan, Chris Ho Nello Mainolfi, Anthony Slavin & Jared A. Gollob Nature Medicine

A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients (2023) Barbara Klughammer, Luca Piali, Alexandra Nica, Sandra Nagel, Lorna Bailey, Christoph Jochum, Stanislav Ignatenko, Angela Bl?uer,Sabrina Danilin, Pratiksha Gulati, Joanne Hayward, Petar Scepanovic, Jitao David Zhang, Satish Bhosale, Chui Fung Chong, Andreas Christ Clinical and Translational Medicine

Enabling the evaluation of COVID-19 vaccines with correlates of protection (2023) Arnaud Marchant, Pierre Van Damme, Stanley Plotkin, Pieter Neels, Maria Cristina Cassetti, Jakob Cramer, Marion F. Gruber, David Goldblatt, Deborah King, Wendy Hartig-Merkel, Joris Vandeputte Biologicals

Seladelpar treatment reduces interleukin-31 and pruritus in patients with primary biliary cholangitis (2023) Andreas E. Kremer, Marlyn J. Mayo, Gideon M. Hirschfield, Cynthia Levy, Christopher L. Bowlus, David E. Jones, Jeff D. Johnson, Charles A. McWherter, Yun-Jung Choi Hepatology

Effect of pegbelfermin on NASH and fibrosis-related biomarkers and correlation with histological response in the FALCON 1 trial (2023) Elizabeth A. Brown, Anne Minnich, Arun J. Sanyal, Rohit Loomba, Shuyan Du, John Schwarz, Richard L. Ehman, Morten Karsdal, Diana J. Leeming, Giovanni Cizza, Edgar D. Charles JHEP Reports

Elevated Levels of the Cytokine LIGHT in Pediatric Crohns Disease (2023) Christopher J Cardinale, Debra J Abrams, Frank D Mentch, John A Cardinale, Xiang Wang, Charlly Ka, Patrick M A Sleiman, Hakon Hakonarson Journal of Immunology

Inflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD (2023) Stefanie Lerche, Milan Zimmermann, Benjamin Roeben, Isabel Wurster, , Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Meike Jakobi, Thomas O. Joos, Thomas Knorpp, Nicole Schneiderhan-Marra and Kathrin Brockmann Nature

Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans (2023) Stavros Zanos, Despoina Ntiloudi, John Pellerito, Richard Ramdeo, John Graf, Kirk Wallace, Victoria Cotero, Jeff Ashe, Jessica Moon, Meghan Addorisio, David Shoudy, Thomas R. Coleman, Michael Brines, Chris Puleo, Kevin J. Tracey, Sangeeta S. Chavan Brain Stimulation

Evaluation of BMS-986142, a reversible Brutons tyrosine kinase inhibitor, for the treatment of rheumatoid arthritis: a phase 2, randomised, double-blind, dose-ranging -ranging, placebo controlled, adaptive design study (2023) Philip G Conaghan, Miroslawa Nowak, Shuyan Du, Yi Luo, Jessica Landis, Chahin Pachai, Aberra Fura, Ian M Catlett, Dennis M Grasela, Mikkel ?stergaard Rheumatoloty

Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas (2023) Andrew L Coveler, David C Smith, Tycel Phillips, Brendan D Curti, Sanjay Goel, Amitkumar N Mehta, Timothy M Kuzel, Svetomir N Markovic, Olivier Rixe, David L Bajor, Thomas F Gajewski, Martin Gutierrez, Hun Ju Lee, Ajay K Gopal, Paolo Caimi, Elisabeth I Heath, John A Thompson, Sahar Ansari, Celine Jacquemont, Ariel Topletz-Erickson, Peigen Zhou, Michael W Schmitt, Juneko E Grilley-Olson Journal for ImmunoTherapy of Cancer

Phase 1 trial of bemcentinib (BGB324), a first-in-class, selective AXL inhibitor, with docetaxel in patients with previously treated advanced non-small cell lung cancer (2023) Sheena Bhalla, FarjanaJ. Fattah, Chul Ahn, Jessica Williams, Alyssa Macchiaroli, Jonathan Padro, Mereth Pogue, Jonathan E. Dowell, William C. Putnam, Nigel McCracken, David Micklem, Rolf, A. Brekken, David E. Gerber Lung Cancer

A phase Ib/II study of galunisertib in combination with nivolumab in solid tumors and non-small cell lung cancer (2023) Ernest Nadal, Mansoor Saleh , Santiago Ponce Aix , Maria Ochoa de Olza, Sandip Pravin Patel , Scott Antonia, Yumin Zhao, Ivelina Gueorguieva, Michael Man, Shawn T. Estrem, Jiangang Liu, Emin Avsar, Wen Hong Lin, Karim A. Benhadji, Leena Gandhi, Susan C. Guba and Inmaculada Ales Diaz BMC Cancer

Quantifying the spatial clustering characteristics of radiographic emphysema explains variability in pulmonary function (2023) Brian E. Vestal, Debashis Ghosh, Ra?l San Jos? Est?par, Katerina Kechris, Nature

Tyrosine kinase signaling-independent MET-targeting with CAR-T cells (2023) Anna Qin1, Yuan Qin1, Joseph Lee2, Anna Anna Qin, Yuan Qin1, Joseph Lee, Anna Musket, Mingyao Ying, Giedre Krenciute, Francesco M. Marincola5, Journal of Translational Medicine

3Repetitive xenon treatment improves post-stroke sensorimotor and neuropsychiatric dysfunction (2022) Dandekar MP, Yin X, Peng T, Devaraj S, Moarles R, McPherson DD, Huang S Journal of Affective Disorders

Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study (2022) Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong M, Musholt PB, Kurbasic A, De Masi F, Tsirigos K, Pedersen HK, Gudmundsdottir V, Thomas CE, Banasik K, Jennison C, Jones A, Kennedy G, Bell J, Thomas L, Frost G, Thomsen H, Allin K, Hansen TH, Vestergaard H, Hansen T, Rutters F, Elders P, tHart L, Bonnefond A, Canouil M, Brage S, Kokkola T, Heggie A, McEvoy D Cell Reports Medicine

Whole-blood cytokine secretion assay as a high-throughput alternative for assessing the cell-mediated immunity profile after two doses of an adjuvanted SARS-CoV-2 recombinant protein vaccine candidate (2022) De Rosa SC, Cohen KW, Bonaparte M, Fu B, Garg S, Gerard C, Goepfert PA, Huang Y, Larocque D, McElrath MJ, Morris d, Van der Most R, de Bruyn G, Anke Pagnon Clinical & Translational Immunology

Cellular and humoral immunity to SARS-CoV-2 infection in multiple sclerosis patients on ocrelizumab and other disease-modifying therapies: a multi-ethnic observational study (2022) Kister I, Patskovsky Y, Curtin R, Pei J, Perdomo K, Rimler Z, Voloshyna I, Samanovic MI, Cornelius AR, Velmurugu Y, Nyovanie S, Kim J, Tardio E, Bacon TE, Zhovtis L, Ryerson LZ, Raut P, Pedotti R, Hawker K, Raposo C, Priest J, Cabatingan M, Winger RC, Mulligan MJ, Krogsgaard M, Silverman GJ medRxiv

Dissection of depression heterogeneity using proteomic clusters (2022) van Haeringen M, Milaneschi Y, Lamers F, Penninx BWJH, Jansen R Psychological Medicine

T cell apoptosis characterizes severe Covid-19 disease (2022) Andre S, Picard M, Cezar R, Roux-Dalvai F, Alleaume-Butauz A, Soundaramourty C, Santa Cruz A, Mendes-Frias A, Gotti C, Leclercq M, Nicolas A, Tauzin A, Carvalho A, Capela c, Pedrosa J, Castro AG, Kundura L, Loubet P, Sotto A, Muller L, Lefrant JY, Roger C, Claret PG, Duvnjak S, Tran TA, Racine G, zghidi-Abouzid O, Nioche P, Silvestre R, Droit A, Mammano F, Corbeau P, Estaquier J CDD Press

Antibody profiles in COVID-19 convalescent plasma prepared with amotosalen/UVA pathogen reduction treatment (2022) Bagri A, de Assis RR, Tsai CT, Simmons G, Mei ZW, Von Goetz M, Gatmaitan M, Stone M, Di Germanio C, Martinelli R, Darst O, Rioveros J, Robinson PV, Ward D, Ziman A, Settel D, Khan S, Busch MP, Felgner PL, Corash LM Transfusion

Platelet-derived growth factor-BB and white matter hyperintensity burden in APOE4 carriers (2022) Arunima Kapoor, Daniel A Nation Cerebral Circulation - Cognition and Behavior

Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin (2022) Christina B. Joseph, Marta Mariniello, Ayumi Yoshifuji, Guglielmo Schiano, Jennifer Lake, Jonathan Marten, Anne Richmond, Jennifer E. Huffman, Archie Campbell, Sarah E. Harris, Stephan Troyanov, Massimiliano Cocca, Antonietta Robino, S?bastien Th?riault, Kai-Uwe Eckardt, Matthias Wuttke, Yurong Cheng, Tanguy Corre, Ivana Kolcic, Corrinda Black, Vanessa Bruat, Maria Pina Concas, Cinzia Sala, Stefanie Aeschbacher, Franz Schaefer, Sven Bergmann, Harry Campbell, Matthias Olden, Ozren Polasek, David J. Porteous, Ian J. Deary, Francois Madore, Philip Awadalla, Giorgia Girotto, Sheila Ulivi, David Conen, Elke Wuehl, Eric Olinger, James F. Wilson, Murielle Bochud, Anna K?ttgen, Caroline Hayward and Olivier Devuyst Journal of the American Society of Nephrology

Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients (2022) Marion Cremoni, S?bastien Cuozzo, Emanuela Martinuzzi, Susana Barbosa, Nadia Ben Hassen, Filippo Massa, Elisa Demonchy, Matthieu Durand, Olivier Thaunat, Vincent Esnault, Moglie Le Quintrec, Sophie Caillard, Nicolas Glaichenhaus, and Antoine Sicard Viruses

Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia (2022) Suzette L. Pereira , Marni E. Shoemaker, Susan Gawel, Gerard J. Davis Menghua Luo, Vikkie A. Mustad and Joel T. Cramer Nutrients

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines (2022) Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, L?lia Delamarre & Ira Mellman Nature Immunology

Utility of urinary cytokine levels as predictors of the immunogenicity and reactogenicity of AS01-adjuvanted hepatitis B vaccine in healthy adults (2022) Wivine Burny, Caroline Herve, Magalie Caubet, Juan Pablo Yazabal, Arnaud M Didierlaurent Vaccine

Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women (2022) Nardhy Gomez-Lopez, Roberto Romero, Li Tao, Meyer Gershater, Yaozhu Leng, Chengrui Zou, Marcelo Farias-Jofre, Jose Galaz, Derek Miller, Adi L. Tarca, Marcia Arenas-Hernandez, Gaurav Bhatti, Valeria Garcia-Flores, Zhenjie Liu, Robert Para, Tomi Kanninen, Ola Hadaya, Carmen Paredes and Yi Xu Journal of Immunology

Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults (2022) DidacVidal-Pi?eiro, ?ysteinS?rensen, KajBlennow, Elettra Capogna, Nathalie Bodd Halaas, Ane-VictoriaId, Athanasia Monica Mowinckel, Joana Braga Pereira, Leiv Otto Watne, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell Neurobiology of Aging

Defective type I interferon immunity is associated with increasing COVID-19 severity (2022) Nika?a Smith, C?line Poss?m?, Vincent Bondet, Jamie Sugrue, Liam Townsend, Bruno Charbit, Vincent Rouilly, Violaine Saint-Andr?, Tom Dott, Andre Rodriguez Pozo, Nader Yatim, Olivier Schwartz, Minerva Cervantes-Gonzales, Jade Ghosn, Paul Bastard, Jean Laurent Casanova, Tali-Anne Szwebel, Benjamin Terrier, Niall Conlonm, Cliona O?Farrelly, Cl?ona N? Cheallaigh, Nollaig M Bourke, Darragh Duffy Research Square

An Exploratory Analysis of Biomarkers of Perihematomal Edema in the CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial (2022) Jay B Lusk, Jesse Troy, Nathaniel Nowacki, Peter G Kranz, Maureen Maughan, Daniel T Laskowitz, Michael L James Journal of Stroke and Cerebrovascular Diseases

Pre- and post-operative psychological interventions to prevent pain and fatigue after breast cancer surgery (PREVENT): Protocol for a randomized controlled trial (2022) Silje Endresen Reme, Alice Munk, Marianne Therese Smogeli Holter, Ragnhild S. Falk, Henrik B?rsting Jacobsen Plos One

Childhood trauma and LPS-stimulated inflammation in adulthood: Results from the Netherlands Study of Depression and Anxiety (2022) Ricki M.de Koning, Erika Kuzminskaite, Christiaan H.Vinkers, Erik J. Giltay, Brenda W.J.H.Penninx Brain, Behavior, and Immunity

Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Renal Allograft Rejection: Accumulation of Antibody-neutralized Interleukin-6 Without Signs of Proinflammatory Rebound Phenomena (2022) Anita Borski, Farsad Eskandary, Susanne Haindl, Konstantin Doberer, Jakob M?hlbacher, Katharina A Mayer, Klemens Budde, Philip F Halloran, Edward Chong, Bernd Jilma, Georg A B?hmig, Markus Wahrmann Transplantation

CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-infammatory cytokine production (2022) Rajula Gaur, Kofi A Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik 1, Jamie Connarn 1, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ram?rez-Valle Arthritis Research and Therapy

Early stimulated immune responses predict clinical disease severity in hospitalized COVID-19 patients (2022) Rebecka Svanberg, Cameron MacPherson, Adrian Zucco, Rudi Agius, Tereza Faitova, Michael Asger Andersen, Caspar da Cunha-Bang, Lars Klingen Gj?rde, Maria Elizabeth Engel M?ller, Patrick Terrence Brooks, Birgitte Lindegaard, Adin Sejdic, Anne Ortved Gang, Ditte Stampe Hersby, Christian Brieghel, Susanne Dam Nielsen, Daria Podlekareva, Annemette Hald, Jakob Thaning Bay, Hanne Marquart, Jens Lundgren, Anne-Mette Lebech, Marie Helleberg, Carsten Utoft Niemann & Sisse Rye Ostrowski Communications Medicine

Live enteroviruses, but not other viruses, detected in human pancreas at the onset of type 1 diabetes in the DiViD study (2022) Lars Krogvold, Angelo Genoni, Anna Puggioni, Daniela Campani, Sarah J. Richardson, Christine S. Flaxman, Bj?rn Edwin, Trond Buanes, Knut Dahl-J?rgensen & Antonio Toniolo Diabetologia

Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction (2022) Upendra Chalise, Mediha Becirovic-Agic, Jocelyn R. Rodriguez-Paar, Shelby R. Konfrst, Sharon D. B. de Morais, Catherine S. Johnson, Elizabeth R. Flynn, Michael E. Hall, Daniel R. Anderson, Leah M. Cook, Kristine Y. DeLeon-Pennell & Merry L. Lindsey Journal of Cardiovascular Translational Research

Exploration of the induced cytokine responses in European Lyme neuroborreliosis: A longitudinal cohort study (2022) Rosa Maja M?hring Gynthersen, Mathilde Orbaek, Helene Mens, Christian Stenor, Lothar Wiese, Sisse Rye Ostrowski, Susanne Dam Nielsen, Anne-Mette Lebech Ticks and Tick-borne Diseases

Sex differences in Alzheimer?s disease: plasma MMP-9 and markers of disease severity (2022) Amaryllis A. Tsiknia, Erin E. Sundermann, Emilie T. Reas, Steven D. Edland, James B. Brewer, Douglas Galasko & Sarah J. Banks Alzheimers Research & Therapy

Distinct Immune Reconstitution Profiles Captured by Immune Functional Assays at 6 Months Post Allogeneic Hematopoietic Stem Cell Transplantation (2022) William Mouton, Anne Conrad, Vincent Alcazer, Mathilde Boccard, Maxime Bodinier, Guy Oriol, Fabien Subtil, Helene Labussiere-Wallet, Sophie Ducastelle-Lepretre, Fiorenza Barraco, Marie Balsat, Gaelle Fossard, Karen Brengel-Pesce, Florence Adler, Sophie Trouillet-Assant Transplantation and Cellular Therapy

First-in-human study of deucravacitinib: A selective, potent, allosteric small-molecule inhibitor of tyrosine kinase 2 (2022) Ian M Catlett, Urvi Aras, Lars Hansen, Yali Liu, Di Bei, Ihab G Girgis, Bindu Murthy Clinical Translational Science

Autologous NK cells propagated and activated ex vivo decrease senescence markers in human PBMCs (2022) Nickolas Chelyapov, Toai T Nguyen, Rafael Gonzalez Biochemistry and Biophysics Reports

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity (2022) Nika?a Smith, C?line Poss?m?, Vincent Bondet, Jamie Sugrue, Liam Townsend, Bruno Charbit, Vincent Rouilly, Violaine Saint-Andr?, Tom Dott, Andre Rodriguez Pozo, Nader Yatim, Olivier Schwartz, Minerva Cervantes-Gonzalez, Jade Ghosn, Paul Bastard, Jean Laurent Casanova, Tali-Anne Szwebel, Benjamin Terrier, Niall Conlon, Cliona OFarrelly, Cl?ona N? Cheallaigh, Nollaig M Bourke, Darragh Duffy Nature Communciations

Efficacy and exploratory biomarker analysis of entinostat plus exemestane in advanced of recurrent breast cancer: phase II randomized controlled trial (2022) Hiroji Iwata, Rikiya Nakamura, Norikazu Masuda, Toshinari Yamashita, Yutaka Yamamoto, Kokoro Kobayashi, Junji Tsurutani, Tsutomu Iwasa, Kan Yonemori, Kenji Tamura, Tomoyuki Aruga, Eriko Tokunaga, Koji Kaneko, Min-Jung Lee, Akira Yuno, Azusa Kawabata, Toshihiro Seike, Ayumi Kaneda, Yozo Nishimura, Jane B Trepel, Shigehira Saji Japanese Journal of Clinical Oncology

Are U-shaped relationships between risk factors and outcomes artifactual? (2022) Reema Shah, Lehana Thabane, Hertzel C. Gerstein Journal of Diabetes

Innate immune function during antineoplastic treatment is associated with 12-months survival in non small cell lung cancer (2022) Heidi Ryssel, Kristian Egebjerg, Susanne Dam Nielsen, Jens Lundgren5,6, Mette P?hl, Seppo W. Langer2, Andreas Kjaer, Sisse Rye Ostrowski and Barbara Malene Fischer Frontiers in Immunology

Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-? and tau pathology in Alzheimer?s disease (2022) Zhi-Bo Wang, Ya-Hui Ma1, Yan Sun1, Lan Tan1, Hui-Fu Wang, Jin-Tai Yu and for the Alzheimer?s Disease Neuroimaging Initiative Journal of Neuroinflammation

Hybrid and vaccine-induced immunity against SARS-CoV-2 in MS patients on different disease-modifying therapies (2022) Ilya Kister , Ryan Curtin, Jinglan Pei, Katherine Perdomo, Tamar E. Bacon, Iryna Voloshyna, Annals of Clinical and Translational Neurology

Peripheral lymphocyte signaling pathway deficiencies predict treatment response in first-onset drug-na?ve schizophrenia (2022) Santiago G. Lago, Jakub Tomasik, Geertje F. Rees, Nitin Rustogi, Javier Vazquez-Bourgon, Sergi Papiol, Paula Suarez-Pinilla, Benedicto Crespo-Facorro, Sabine Bahn Brain Behavior and Immunity

Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation (2022) Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Li Tao, Catherine Demery-Poulos, Marcia Arenas-Hernandez, Gaurav Bhatti, Zhenjie Liu, Naoki Kawahara, Tomi Kanninen, Zachary Shaffer, Tinnakorn Chaiworapongsa, Kevin R. Theis, Adi L. Tarca & Nardhy Gomez-Lopez Inflammation Research

A Phase Ib Dose-finding Study of Panobinostat and Ruxolitinib in Myelofibrosis (2022) Claire Harrison Florian H. Heidel, Alessandro M. Vannucchi, Jean-Jacques Kiladjian, Amjad Hayat, Francesco Passamonti, Eibhlin Conneally, Thomas Kindler, Bruno Martino,9 Daniel B. Lipka, Tommaso Stefanelli, Pantelia Roussou,Davide Germano,Jacqueline Ewan, and Vincent Ribrag Hemasphere

Plasma adiponectin levels predict cognitive decline and cortical thinning in mild cognitive impairment with beta-amyloid pathology (2022) Keun You Kim, Junghee Ha, Minae Kim, So Yeon Cho, Hyunjeong Kim & Eosu Kim Alzheimers Research & Therapy

Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response (2022) Adam J. Walker, Mohammadreza Mohebbi, Michael Maes, Michael Berk, Ken Walder, Chiara C. Bortolasci, Zoe SJ. Liu, Chee H. Ng, Melanie M. Ashton, Lesley Berk, Ajeet B. Singh, Gin S. Malhi Olivia M. Dean Brain, Behavior, & Immunity - Health

Assessment of advanced glycation end products and receptors and the risk of dementia (2021) Chen J, Mooldijk SS, Licher S, Waqas K, Ikram MK, Uitterlinden AG, Zillikens MC, Ikram MA JAMA Network Open

A phase 1b trial of the CXCR4 inhibitor mavorixafor and nivolumab in advanced renal cell carcinoma patients with no prior response to nivolumab monotherapy (2021) Choueiri TK, Atkins MB, Rose TL, Alter RS, Yawen J, Niland K, Wang Y, Arbeit R, Parasuraman S, Gan L, McDermott DF Investigational New Drugs

First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects (2021) Yang J, Lickliter JD, Hilson JL, Means GD, Sanderson RJ, Carley K, Tercero A, Manjarrez KL, Wiley JR, Peng SL Clinical and Translational Science

LY3022855, an anti-colony stimulating factor-1 receptor (CSF-1R) monoclonal antibody, in patients with advanced solid tumors refractory to standard therapy: phase 1 dose-escalation trial (2021) Dowlati A, Jarvey RD, Carvajal RD, Hamid O, Klempner SJ, Wook Kauh JS, Peterson DA, Yu D, CHapman SC, Szpurka AM, Carlsen M, Quinlan T, Wesolowski R Investigational New Drugs

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers (2021) Mezghiche I, Yahia-Cherbal H, Rogge L, Bianchi E Expert Review of Clinical Immunology

Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response (2021) Aevermann B, Shannon CP, Novotny M, Ben-Othman R, Cai B, Zhang Y, Ye JC, Kobor MS, Gladish N, Lee A, Blimke TM, Hancock RE, Llibre A, Duffy D, Koff WC, Sadarangani M, Tebbutt SJ, Kollmann TR, Scheuermann RH medRxiv

Novel signatures associated with systemic lupus erythematosus clinical response to IFN-a/-? inhibition (2021) Seridi L, Cesaroni M, Orillion A, Schreiter J, Chevrier M, Marciniak S, Migone TS, Stohl W, Chatham WW, Furie RA, Benson J, Jordan J Lupus

TNFRSF1B gene variants and related soluble TNFR2 levels impact reilience in Alzheimers disease (2021) Pillai JA, Bebek G, Khrestian M, Bena J, Bergmann CC, Bush WS, Leverenz JB, Bekris LM Frontiers in Aging Neuroscience

Influence of cell quality on inflammatory biomarkers in COPD sputum supernatant (2021) Pedersen F, Trinkmann F, Abdo M, Kirsten AM, Rabe KF, Watz H, Baraldo S, Saetta M, Hohlfeld JM, Holz O International Journal of Chronic Obstructive Pulmonary Disease

Molecular correlates of response to nivolumab at baseline and on treatment in patients with RCC (2021) Ross-Macdonald P, Walsh AM, Chasalow SD, Ammar R, Papillon-Cavanagh S, Szabo pm, Choueiri TK, Sznol M, Wind-Rotolo M Journal for Immunotherapy for Cancer

Identifying associations among genomic, proteomic and imaging biomarkers via adaptive sparse multi-view canonical correlation analysis (2021) Du L, Zhang J, Liu F, Wang H, Guo L, Han J, the Alzheimers Disease Neuroimaging Initiative Medical Image Analysis

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Correlative serum biomarker analyses in the phase 2 trial of lenvatinib-plus-everolimus in patients with metastatic renal cell carcinoma (2021) Lee CH, Motzer RJ, Glen H, Michaelson MD, Larkin J, Minoshima Y, Kanekiyo M, Ikezawa H, Sachdev P, Dutcus CE, Funashashi Y, Voss MH British Journal of Cancer

Muscle damage in systemic sclerosis and CXCL10: The potential therapeutic role of PDE5 inhibition (2021) Corinalesi C, Ross RL, Abignano G, Antinozzi C, Marampon F, di Luigi L, Buch MH, Riccieri V, Lenzi A, Crescioli C, Del Galdo F International Journal of Molecular Sciences

Differential response induced by LPS and MPLA in immunocompetent and septic individuals (2021) Vega CA, Karakike E, Bartolo F, Mouton W, Cerrato E, Brengel-Pesce K, Giamarellos-Bourboulis EJ, Mallet F, Trouillet-Assant S Clinical Immunology

Characterization of the pathophysiological determinants of diarrheagenic Escherichia coli infection using a challenge model in healthy adults (2021) van Hoffen E, Mercenier A, Vidal K, Benyacoub J, Schloesser J, Kardinaal A, Lucas-van de Bos E, van Alen I, Rogero I, Duintjer K, Berendts A, Albers R, Kleerebezem M, Bruggencate ST Scientific Reports

Development of an affordable, sustainable and efficacious plant-based immunomodulatory food ingredient based on bell pepper or carrot RG-I pectic polysaccharides (2021) McKay S, Oranje P, Helin J, Koek JH, Kreijveld E, van den Abbeele P, Phol u, Bothe G, Tzoumaki M, Aparicio-Vergara M Nutrients

Nonclinical development of SRK-181: An anti-latent TGFb1 monoclonal antibody for the treatment of locally advanced or metastatic solid tumors (2021) Welsh BT, Faucette R, Bilic S, Martin CJ, Schurpf T, Chen D, Nicholls S, Lansita J, Kalra A International Journal of Toxicology

Functional immune reconstitution early after allogeneic hematopoietic cell transplantation: A comparison of pre- and post-transplantation cytokine responses in stimulated whole-blood (2021) Gjaerde LK, Brooks PT, Andersen NS, Friss LS, Kornblit B, Petersen SL, Schjodt I, Nielsen SD, Ostrowski SR, Sengelov H Scandinavaian Journal of Immunology

Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results (2021) Advani R, Moskowitz AJ, Bartlett NL, Vose J, Ramchandren R, Feldman T, LaCasce AS, Christian B, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF Blood

NT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia ? A brief report from the ORIGIN trial (2021) Wijkman MO, Claggett BL, Pfeffer MA, Pare G, McQueen M, Hess S, Fu Lee S, Gerstein HC Journal of Diabetes and its Complications

Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1-2, dose-ranging study (2021) Goepfert PA, Fu B, Chabanon AL, Bonaparte MI, Davis MG, Essink BJ, Frank I, Haney O, Janosczyk H, Keefer MC, koutsoukos M, Kimmel MA, Masotti R, Savarino SJ, Schuerman L, Schwarts H, Sher LD, Smith J, Tavares-Da-Silva F, Gurunathan S, DiazGranados CA, de Bruyn G The Lancet, Infectious Disease

The Effect of a natural oral nutritional supplement on the level of intra-articular inflammatory mediators in patients with osteoarthritis of the knee (2021) Sharkey P, Shah Z, Gross M, Meade T, Davidoff S, Shohat N, Parvizi J Journal of Orthopaedic Experience and Innovation

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Ligand conjugate structure activity relationships and enhanced endosomal escape with a targeted polymer micelle in non-human primates (2021) Holland RJ, Lam K, Ye X, Martin AD, Wood MC, Palmer L, Fraser D, McClintock K, Majeski S, Jarosz A, Lee ACH, Thi EP, Judge A, Heyes J Molecular Therapy

Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons (2021) Anderson JA, Lea AJ, Voyles TN, Akinyi MY, Nyakundi R, Ochola L, Omondi M, Nyundo F, Zhang Y, Campos FA, Alberts SC, Archie EA, Tung J bioRxiv preprint

The migration of human follicular dendritic cell-like cell is facilitated by matrix metalloproteinase 3 expression that is mediated through TNFa-ERK1/2-AP1 signaling (2021) Pak HK, Kim YW, Nam B, Lee AN, Roh J, Gil M, Liu C, Chung YS, Park CS Journal of Immunology Research

Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming (2021) Hirschberger S, Straub G, Effinger D, Marstaller X, Ferstl A, Muller MB, Wu T, Hubner M, Rahmel T, Mascolo H, Exner N, Heb J, Kreth FW, Unger K, Kreth S EMBO Molecular Medicine

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Proteomic correlates of cortical thickness in cognitively normal individuals with normal and abnormal cerebrospinal fluid beta-amyloid 1-42 (2021) Ekblad LL, Visser PJ, Tijims BM, for the Alzheimers Disease Neuroimaging Initiative Neurobiology of Aging

Improving the power to detect indirect effects in mediation analysis (2021) Kidd J, Lin DY Conrell University

CSF proteomic Alzheimers disease-predictive subtypes in cognitively intact amyloid negative individuals (2021) Tijms BM, Gobom J, Teunissen C, Dobricic V, Tsolaki M, Verhey F, Popp J, Martinex-Lage P, Vandenberghe R, Lleo A, Luis-Molineuvo J, Engelborghs S, Freund-Levi Y, Foelich L, Bertram L, Lovestone S, Streffer J, Vos S, ADNI, Blennow K, Scheltens P, Zetterberg H, Jelle Visser P Proteomes

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Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll-like receptors 7 and 8 (2021) Port A, Shaw JV, Klopp-Schulze L, Bytyqi A, Vetter C, Husey E, Mammasse N, Ona V, Bachmann A, Strugala D, Reh C, Goteti K Pharmacology Researh and Perspective

Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease (2021) Pierson SK, Shenoy S, Oromendia AB, Gorzewski AM, Pai RA, Nabel CS, Ruth JR, parente SAT, Arenas DJ, Guilfoyle M, Reddy MP, Weinblatt M, Shadick N, Bower M, Pria AD, Masaki Y, Katz L, Mezey J, Beineke P, Lee D, Tendler C, Kambayashi T, Fossa A, van Rhee F, Fajgenbaum DC Blood Advances

Association of systemic inflammation with depressive symptoms in individuals with COPD (2021) Strollo HC, Nouraie SM, Hoth KF, Riley CM, Karoleski C, Zhang Y, Hanania NA, Bowler RP, Bon J, Sciurba FC International Journal of Chronic Obstructive Pulmonary Disease

A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis (2021) Alexander Jr LC, McHorse G, Huebner JL, Bay-Jensen AC, Karsdal MA, Kraus VB Arthritis Research & Therapy

Distinct patterns of blood cytokines beyond a cytokine storm predict mortality in COVID-19 (2021) Herr C, Mang S, Mozafari B, Guenther K, Speer T, seibert M, Srikakulam SK, Beisswenger C, Ritzmann F, Keller A, Mueller R, smola S, Eisinger D, Zemlin M, Danziger G, Volk T, Hoersch S, Krawczyk M, Lammert F, Adams T, Wagenpfeil G, Kindermann M, Marcu C, Ataya ZWD, Mittag M, Schwarzkopf K, Custodis F, Grandt D, Schaefer H, Eltges K, Lepper PM, Bals R Journal of Inflammation Research

Associations of the cerebrospinal fluid hepatocyte growth factor with Alzheimers disease pathology and cognitive function (2021) Zhao LJ, Wang ZT, Ma YH, Zhang W, Dong Q, Yu JT, Tan L, ADNI BMC Neurology

High insulin in early childhood is associated with subsequent asthma risk independent of body mass index (2021) Carr TF, Granell R, Stern DA, Guerra S, Wright A, Halonen M, Henderson J, Martinex FD The Journal of Allergy and Clinical Immunology: In Practice

Validation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial (2021) Pigeyre M, Hess S, Gomez MF, Asplund O, Groop L, Pare G, Gerstein H Diabetologia

Serum peptidome: diagnostic window into pathogenic processes following occupational exposure to carbon nanomaterials (2021) Mostovenko E, Dahm MM, Schubauer-Berigan MK, Eye T, Erdely A, Young TL, Campen MJ, Ottens AK Particle and Fibre Toxicology

Interferon genes are influenced by 17?-estradiol in SLE (2021) Singh RP, Hahn BH, Bischoff DS Frontiers in Immunology

Soluble amyloid-beta isoforms predict downstream Alzheimers disease pathology (2021) Povala G, Bellaver B, De Bastiani MA, Brum WS, Ferreira PCL, Bieger A, Pascoal TA, Benedet AL, Souza DO, Araujo RM, Zatt B, Rosa-Neto P, Zmmer ER Research Square

Biomarker signature in cancer patients with and without venous thromboembolism events: a substudy of CASSINI (2021) Khorana A, Barnard J, Wun T, Vijapurkar U, Damaraju CV, Moore K, Wildgoose P, McCrae K Blood Advances

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Filgotinib, a JAK1 Inhibitor, Modulates Disease-Related Biomarkers in Rheumatoid Arthritis: Results from Two Randomized, Controlled Phase 2b Trials. (2020) Tarrant JM, Galien R, Li W, Goyal L, Pan Y, Hawtin R, Zhang W, Van der Aa A, Taylor PC Rheumatol Ther

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Dynamic Aspects of Associations in Coronary Artery Disease: From Intracoronary Imaging to Blood Biomarkers (2020) Buljubasic, N. Erasmus University Rotterdam

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APOE e4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer?s disease (2020) Konijnenberg E, Tijms BM, Gobom J, Dobricic V, Bos I, Vos S, Tsolaki M, Verhey F, Popp J, Martinez-Lage P, Vandenberghe R, Lleo A, Frolich L, Lovestone S, Streffer J, Bertram L, Blennow K, Teunissen CE, Veerhuis R, Smit AB, Scheltens P, Zetterberg H, Visser PJ Alzheimers Research & Therapy

Systematic investigation of polyurethane biomaterial surface roughness on human immune responses in vitro (2020) Segan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H BioMed Research International

A comprehensive systematic review of CSF proteins and peptides that define Alzheimer?s disease (2020) Pedrero-Prieto CM, Garcia-Carpintero S, Frontinan-Rubio J,Llanos-Gonzalez E, Aguilera Garcia C, Alcain FJ, Lindberg I, Duran-Prado M, Peinado J, Rabanal-Ruiz Y Clinical Proteomics

Innate Immune Stimulation of Whole Blood Reveals IFN-1 Hyper-Responsiveness in Type 1 Diabetes (2020) Rodrigues KB, Dufort MJ, Llibre A, Speake C, Jubayer Rahman M, Bondet V, Quiel J, Linsley PS, Greenbaum CJ, Duffy D, Tarbell KV Diabetologia

Serum biomarkers that predict lean mass loss over bed rest in older adults: An exploratory study (2020) Gawel SH, Davis GJ, Luo M, Deutz NEP, Wolfe RR, Pereira SL Clinica Chimica Acta

Multiple Biomarker Approach for the Diagnosis and Therapy of Rheumatoid Arthritis (2020) Savvateeva E, Smoldovskaya O, Feyzkhanova G, Rubina A Critical Reviews in Clinical Laboratory Sciences

Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation (2020) Jorgensen SE, Christiansen M, Host C, Glerup M, Mahler B, Lausten MM, Gad HH, Hartmann R, Herlin T, Mogensen TH Rheumatology

Comparison of host immune responses to LPS in human using an immune profiling panel, in vivo endotaxemia versus ex vivo stimulation (2020) Tawfik DM, Lankelma JM, Vachot L, Cerrato E, Pachot A, Wiersinga WJ, Textoris J Scientific Reports

Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition (2020) Laino AS, Woods D, Vassallo M, Qian X, Tang H, Wind-Rotolo M, Weber J Journal for ImmunoTherapy of Cancer

Proteomic profiling as a diagnotic biomarker for discriminating between bipolar and unipolar depression (2020) Kittel-Schneider S, Hahn T, Haenisch F,McNeill R, Reif A, Bahn S Frontiers in Psychiatry

Elevated plasma cortisol associated with larger ventricles and smaller hippocampal volumes - a study in 2 independent elderly cohorts (2020) Rajagopalan P, Nho K, Risacher SL, Jahanshad N, Boyle CP, Saykin AJ, Thompson PM bioRxiv

The effects of rare SERPINA1 variants on lung function and emphysema in SPIROMICS (2020) Ortega VE, Li X, ONeal WK, Lackey L, Ampleford E, Hawkins GA, Grayeski P, Laederach A, Barjaktarevic I, Barr RG, Cooper C, Douper D, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Paine R III, Peters SP, Pirozzi C, Rennard SI, Woodruff PG, Hoffman EA, Meyers DA, Bleecker ER American Journal of Respiratory and Critical Care Medicine

Fibroblasts from distinct pancreatic pathologies exhibit disease-specific properties (2020) Barrera LN, Evans A, Lane B, Brumskill S, Oldfield FE, Campbell F, Andrews T, Lu Z, Perez-Mancera PA, Liloglou T, Ashworth M, Jalali M, Dawson R, Nunes Q, Phillips PA, Timms JF, Halloran C, Greenhalf W, Neoptolemos JP, Costello E Cancer Research

Predicting and elucidating the etiology of fatty liver disease: a machine learning modeling and validation study in the IMI DIRECT cohorts (2020) Atabaki-Pasdar N, Ohlsson M, Vinuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL, Koivula RW, Kurbasic A, Mutie PM, Fitipaldi H, Fernandez J, Dawed AY, Giordano GN, Forgie IM, McDonald TJ, Rutters F, Cederberg H, Chaanova E, Dale M, De Masi F, Thomas CE, Allin KH, Hansen TH, Heggie A, Hong MG, Elders PJM, Kennedy G, Kokkola T, Pedersen HK, Mahajan A, McEvoy D, Pattou F, Raverdy V, Haussler RS, Sharma S, Thomsen HS, Vangipurapu J, Vestergaard H, t Hart LM, Adamski J, Musholt P, Brage S, Brunak S, Dermitzakis E, Frost G, Hansen T, Laakso M, pedersen O, Ridderstrale M, Ruetten H, Hattersley AT, Walker M, Beulens JWJ, Mari A, Schwenk JM, Gupta R, McCarthy MI, Pearson ER, Bell JD, Pavo I, Franks PW PLoS Medicine

A phase I study of ASTX660, an antagonist of inhibitors of apoptosis proteins, in adults with advanced cancers or lymphoma (2020) Mita MM, LoRusso PM, Papadopoulos KP, Gordon MS, Mita AC, Ferraldeschi R, Keer H, Oganesian A, Su XY, Jueliger S, Tolcher AW Clinical Cancer Research

Towards standardization of immune functional assays (2020) Mouton W, Albert-Vega C, Boccard M, Bartolo F, Oriol G, Lopez J, Pachot A, Textoris J, Mallet F, Brengel-Pesce K, Trouillet-Assant S Clinical Immunology

Results of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium bacillus calmette guerin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapy (2020) Rentsch CA, Bosshard P, Mayor G, Rieken M, Puschel H, Wirth G, Cathomas R, Parzmair GP, Grode L, Eisele B, Sharma H, Gupta M, Gairola S, Shaligram U, Goldenberger D, Spertini F, Audran R, Enoui M, Beradi S, Hayoz S, Wicki A Oncoimmunology

An integrative study of five biological clocks in somatic and mental health (2020) Jansen R, Verhoeven J, Han LKM, Aberg KA, van den Oord ECGJ, Milaneschi Y, Penninx BWJH bioRxiv

Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus (2020) Smith MA, Chiang CC, Zerrouki K, Rahman S, White W, Streicher K, Rees WA, Schiffenbauer A, Rider LG, Miller FW, Manna Z, Hasni S, Kaplan M, Siegel R, Sinibaldi D, Sanjuan MA, Casey KA Scientific Reports

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitnes in old age (2020) Brigger D, Riether C, van Brummelen R, Mosher KI, Shiu A, Ding Z, Zbaren N, Gasser P, Guntern P, Yousef H, Castellano JM, Storni F, Graff-Radford N, Britschgi M, Grandgirard D, Hinterbrandner M, Siegrist M, Moullan N, Hofstetter W, Leib SL, Villiger PM, Auwerx J, Villeda SA, Wyss-Coray T, Noti M, Eggel A Nature Metabolism

Impact of carbohydrate-reduced nutrition in septic patients on ICU: study protocol for a prospective randomised controlled trial (2020) Rahmel T, Hubner M, Koos B, Wolf A, Willemsen KM, Straub G, Effinger D, Adamzik M, Kreth S BMJ Open

Preoperative TruCulture whole blood cytokine response predicts postoperative inflammation in pancreaticoduodenectomy patients - a pilot cohort study (2020) Aasvang EK, Pitter S, Hansen CP, Storkholm JH, Krohn PS, Burgdorf SK, Von Stemann JH, Lundgren JD, Nielsen SD, Kehlet H, Ostrowski SR Scandinavian Journal of Immunology

Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression (2020) van Eeden WA, van Hemert AM, Carlier IVE, Penninx BWJH, Fried EI, Schoevers R, Giltay EJ Translational Psychiatry

Immune transriptome of cells infected with enterovirus strains obtained from cases of type 1 diabetes (2020) Poma AM, Genoni A, Broccolo F, Denaro M, Pugliese A, Basolo F, Toniolo A Microorganisms

Inexpensive, non-invasive biomarkers predict Alzheimer transition using machine learning analysis of the Alzheimers Disease Neuroimaging (ADNI) database (2020) Beltran JF, Wahba BM, Hose N, Shasha D, Kline RP, ADNI PLoS One

Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study (2020) Genovese MC, Gaylis NB, Sikes D, Kivitz A, Horowitz DL, Peterfy C, Glass EV, Levine YA, Chernoff D The Lancet Rheumatology

Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration (2020) Lashkari K, Teague GC, Beattie U, Betts J,Kumar S, McLaughlin MM, Lopez FJ PLOS One

Model informed dosing regimen and phase I results of the anti-PD-1 antibody budigalimab (ABBV-181) (2020) Powderly J, Spira A, Kondo S, Doi T, Luke JL, Rasco D, Gao B, Tanner M, Cassier PA, Gazzah A, Italiano A, Tosi D, Afar DE, Parikh A, Engelhardt B, Englert S, Lambert SL, Kasichayanula S, Mensing S, Menon R, Vosganian G, Tolcher A Clinical and Translational Science

Reduced chronic toxicity and carcinogenicity in A/J mice in response to life-time exposure to aerosol from a heated tobacco product compared with cigarette smoke (2020) Wong ET, Luettch K, Krishan S, Wong SK, Lim WT, Yeo D, Buttner A, Leroy P, Vuillaume G, Boue S, Hoeng J, Vansheeuwijck P, Peitsch M Toxicological Sciences

Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes (2020) Adams SF, Grimm AJ, Chiang CLL, Mookerjee A, Flies D, Jean S, McCann GA, Michaux J, Pak H, Huber F, Neal C, Dangaj D, Bassani-Sternberg M, Rusakiewicz S, Facciabene A, Coukos G, Gimotty PA, Kandalaft LE Journal for ImmunoTherapy of Cancer

Molecular biomarkers of anti-TNF response in patients with rheumatoid arthritis (2020) Yoosuf N, Maciejewski M, Ziemek D, Jelinsky S, Folkersen, Muller M, Sahlstrom P, Vivar N, Catrina A, Berg L, Klareskog L, Padyukov L, Brynedal B Arthritis Research & Therapy

Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,30dioxygenase 2, in patients with advanced solid tumors (2020) Naing A, Eder JP, Piha-Paul SA, Gimmi C, Hussey E, Zhang S, Hildebrand V, Hosagrahara V, Habermehl C, Moisan J, Papadopoulos KP Journal for ImmunoTherapy of Cancer

Investigating data-driven biological subtypes of sychiatric disorders using specification-curve analysis (2020) Beijers L, van Loo HM, Romeijn JW, Lamers F, Schoevers RA, Wardenaar KJ Psychological Medicine

Genetics meets proteomics: perspectives for large population-based studies (2020) Suhre K, McCarthy MI, Schwenk JM Nature Reviews Genetics

Modulation of cardiometabolic disease markers by type I interferon inhibition in systemic lupus erythematosus (2020) Casey KA, Smith MA, Sinibaldi D, Seto NL, Playford MP, Wang X, Carlucci PM, Wang L, Illei G, Yu B, Wang S, Remaley AT, Mehta NH, Kaplan MJ, White WI Arthritis Rheumatology

Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimers disease (2020) Pillai JA, Bena J, Bebek Gurkan, Bekris LM, Bonner-Jackson A, Kou L, Pai A, Sorensen L, Neilsen M, Rao SM, Chance M, Lamb BT, Leverenz JB, Alzheimers Disease Neuroimaging Initiative Annals of Clinical and Translational Neurology

HepatoScore-14: Measures of biological heterogeneity significantly improve prediction of hepatocellular carcinoma risk (2020) Morris JS, Hassan MM, Zohner YE, Wang Z, Xiao L, Rashid A, Haque A, Abdel-Wahab R, Mohamed YA, Ballard KL, Wolff RA, George B, Li L, Allen G, Weylandt M, Li D, Wang W, Raghav K, Yao J, Amin HM, Kaseb AO Heptology

Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab - a study protocol (2020) Takeshi N, Kenji I, Daisuke O, Satoshi N, Risa TM, Koji M, Susumu I, Hidehisa S, Yudai K, Riichiro A, Mamitaro O, Koji K, Tatsuro O, Tomomitsu M, Yozo I, Akihiko a, Hiroshi K, Keiji T, Hiroshi M, Tatsuyoshi K, Takuya T, Masashi A, Emi N, Akimchi M, Kyoko t, Yukinobu N, Koji S, Chicharu T, YOko K, Rai F, Sakae K, Eishin M, Akio T, Mchihiro H, Natsuko A, Shigetoshi S, Haruna M, Yutaka H, Motoi T, Hiroyuki M, Norito K, Masutaka F Medicine

First-in-human, single- and multiple-ascending dose studies in healthy subjects to assess pharmacokinetics, pharmacodynamics, and safety/tolerability of iberdomide, a novel cereblon E3 ligase modulator (2020) Ye Y, Gaudy A, Schafer P, Thomas M, Weiss D, Chen N, Liu L, Xue Y, Carayannopoulos L, Palmisano M Clinical Pharmacology in Drug Development

Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study (2020) Albert Vega C, Oriol G, Bartolo F, Lopez J, Pachot A, Rimmele T, Venet F, Leray V, Monneret G, Delwarde B, Brengel-Pesce K, Textoris J, Mallet F, Trouillet-Assant S Scientific Reports

Immune profiling enables stratification of patients with active TB disease or M. tuberculosis infection (2020) Duffy D, Nemes E, Llibre A, Rouilly V, Musvosvi M, Smith N, Filander E, Africa H, Mabwe S, Jaxa L, Charbit B, Mulenga H, the Milieu Interieur Consortium, Tameris M, Walzl G, Malherbe S, Thomas S, Hatherill M, Bilek N, Scriba TJ, Albert ML Clinical Infectious Diseases

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals (2020) Fokersen L, Gustafsson S, Qang Q, Hansen DH, Hedman AK, Schork A, Page K, Zhernakova DV, Wu Y, Peteres J, Eriksson N, Bergen SE, Boutin TS, Bretherick AD, Entroth S, Kalnapenkis A, Gadin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Smith GD, de Masi F, Elmstahl S, Engstrom G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson A, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Magi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Palsson E, Qi T, Sjogren M, Sundstrom J, Surendran P, Vosa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Arnlov J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Homes MV, Ingelsson E, Malarstig A Nature Metabolism

Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial (2020) Aranow C, Atish-Fregoso Y, Lesser M, Mackay M, Anderson E, Chavan S, Zanos TP, Datta-Chaundhuri T, Bouton C, Tracey KJ, Diamond B Annals of the rheumatic diseases

Methamphetamine increases the proportion of SIV-infected microglia/macrophases, alters metabolic pathways, and elevates cell death pathways: a single-cell analysis (2020) Niu M, Morsey B, Lamberty BG, Emanuel K, Yu F, Leon-Rivera R, Berman JW, Gaskill PJ, Matt SM, Ciborowski PS, Fox HS Viruses

Efficacy and safety of abatacept in active primary Sj?grens syndrome: results of a phase III, randomised, placebo-controlled trial (2020) Baer AN, Gottenberg JE, St Clair EW, Sumida T, Takeuchi T, Seror R, Foulks G, Nys M, Mukherjee S, Wong R, Ray N, Boothsma H Annals of the Rheumatic Disease

Basal forebrain degeneration and cortisol as biomarkers mediating Alzheimers disease pathology: a machine learning approach (2020) Nakirikanti AS Research Thesis

The utility of novel urinary biomarkers in mice for drug development studies (2020) Adedeji AO, Gu YZ, Pourmohamad T, Kanerva J, Chen Y, Atabakhsh E, Tackett MR, Chen F, Bhatt B, Gury T, Dorchies O, Sonee M, Morgan M, Burkey J, Gautier JC, McDuffie JE International Journal of Toxicology

Left and right atrial biomarker analysis in atrial fibrillation (2020) Goldberger JJ, Green D, Ringwala S, Andrei AC, Xu Y, Passman R JACC Clinical Electrophysiology

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo (2020) Menegatti S, Guillemot V, Latis E, Yahia-Cherbal H, Mittermuller D, Rouilly V, Mascia E, Rosine N, Koturan S, Millot G, Leloup C, Duffy D, Gleizes A, Hacein-Bey-Abina S, Milieu interieur Consortium, Sellam J, Berenbaum F, Miceli C, Dougados M, Bianchi E, Rogge L Ann Rheum Dis

Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: Machine learning on proteomics from the DETECT cohort (2020) Bauer Y, de Bernard S, Hickey P, Ballard K, Cruz J, Cornelisse P, Chadha-Boreham H, Distler O, Rosenberg D, Doelberg M, Roux S, Nayler O, Lawrie A European Respiratory Journal

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker for COPD (2020) Pratte KA, Curtis JL, Kechris K, Couper D, Cho MH, Silverman EK, DeMeo DL, Sciurba FC, Zhang Y, Ortega VE, ONeal W, Gillenwater LA, Lynch DA, Newell Jr JD, Comellas AP, Castaldi PJ, Miller B, Pouwels SD, ten Hacken NHT, Bischoff R, Klont F, Woodruff P, Paine R, Barr RG, Hoidal J, Doerschuk CM, Charbonnier JP, Sung R, Locantore N, Yonchuk J, Tal-Singer R, Jacobson S, Merrill D, Bowler RP Research Square

Characterization of LY2775240, a selective phosphodiesterase-4 inhibitor, in nonclinical models and in healthy subjects (2020) Patel DR, Urva S, Ho S, Buckman CJ, Ma Y, Lim J, Sissons SE, Zuniga MS, Philips D, Cox K, Dairaghi D Clinical and Translational Science

Systems biology methods applied to blood and tissue for comprehensive analysis of immune response to hepatitis B vaccine in adults (2020) Ben-Othman R, Cai B, Liu AC, Varankovich N, He D, Blimkie TM, Lee AH, Gill EE, Novotny M, Aevermann B, Drissler s, Shannon CP, McCann S, Marty K, Bjornson G, Edgar RD, Lin DTS, Gladish N, MacIsaac J, Amenyogbe N, Chan Q, Libre A, Collin J, Landais, E, Le K, Reiss SM, Koff WC, Havenar-Daughton C, Heran M, Sangha B, Walt D, Krajden M, Crotty S, Sok D, Briney B, Burton DR, Duffy D, Foster LJ, Mohn WW, Kobor MS, Tebbutt SJ, Brinkman RR, Scheuermann RH, Hancock REW, Kollmann TR, Sadarangani M Frontiers in Immunology

Cerebrospinal fluid ceruloplasmin levels predict cognitive decline and brain atrophy in people with underlying ?-amyloid pathology (2020) Diouf I, Bush AI, Ayton S Neurobiology of Disease

Quantitative Assays of Plasma Apolipoproteins. (2020) Poljak A, Duncan MW, Jayasena T, Sachdev PS Methods of Molecular Biology

Synovial tissue transcriptomes of long-standing rheumatoid arthritis are dominated by activated macrophages that reflect microbial stimulation (2020) Smilijanovic B, Grutzkau A, Sorensen T, Grun JR, Vogl T, Bonin M, Schendel P, Stuhlmuller B, Claussnitzer A, Hermann S, Ohrndorf S, Aupperle K, Backhaus M, Radbruch A, Burmester GR, Haupl T Scientific Reports

Inhibition of cytokine signaling by ruxolitinib and implactions for COVID-19 treatment (2020) Yeleswaram S, Smith P, Burn T, Covington M, Juvekar A, Li Y, Squier P, Langmuir P Clinical Immunology

Apremilast Mechanism of Efficacy in Systemic-Naive Patients With Moderate Plaque Psoriasis: Pharmacodynamic Results From the UNVEIL Study (2019) Strober B, Alikhan A, Lockshin B, Shi R, Cirulli J, Schafer P Journal of Dermatological Science

Discovery and validation of a biomarker model (preserve) predictive of renal outcomes after liver transplantation (2019) Levitsky J, Asrani SK, Klintmalm G, Schiano T, Moss A, Chavin K, Miller C, Guo K, Zhao L, Jennings LW, Brown M, Armstrong B, Abecassis M Hepatology

Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab. (2019) Hotchkiss RS, Colston E, Yende S, Crouser ED, Martin GS, Alberson T, Bartz RR, Brakenridge SC, Delano MJ, Park PK, Donnino MW, Tidswell M, Mayr FB, Angus DC, Coopersmith CM, Moldawer LL, Catlett IM, Girgis IG, Ye J, Grasela DM Intensive Care Med

SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus (2019) Smith MA, Henault J, Karnell JL, Parker ML, Riggs JM, Sinibaldi D, Taylor DK, Ettinger R, Grant EP, Sanjuan MA, Kolbeck R, Petri MA, Casey KA Scientific Reports

Extracorporeal apheresis therapy for Alzheimer disease-targeting lipids, stress, and inflammation (2019) Bornstein SR, Voit-Bak K, Rosenthal P, Tselmin S, Julius U, Schatz U, Boehm BO, Thuret S, Kempermann G, Reichmann H, Chrousos GP, Licinio J, Wong ML, Schally AV, Straube R Molecular Psychiatry

Functional immune monitoring in severely injured patients - a pilot study. (2019) Halbgebauer R, Kllermann S, Schafer F, Weckbach S, Weiss M, Barth E, Bracht H, Kalbitz M, Gebhard F, Huber-Lang MS, Perl M Scandinavian Journal of Immunology

Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects (2019) Medvedeva IV, Stokes ME, Eisinger D, LaBrie ST, Ai J, Trotter MWB, Schafer P, Yang R Scientific Reports

A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough. (2019) Ahmad R, Xie L, Pyle M, Suarez MF, Broger T, Steinberg D, Ame SM, Lucero MG, Szucs MJ, MacMullan M, Berven FS, Dutta A, Sanvictores DM, Tallo VL, Bencher R, Eisinger DP, Dhingra U, Deb S, Ali SM, Mehta S, Fawzi WW, Riley ID, Sazawal S, Premji Z, Black R, Murray CJL, Rodriguez B, Carr SA, Walt DR, Gillette MA Science Translational Medicine

Tumor immune microenvironment and genomic evolution in a patient with metastatic triple negative breast cancer and a complete response to atezolizumab. (2019) Molinero L, Li Y, Chang CW, Maund S, Berg M, Harrison J, Fasso M, OHear C, Hedge P, Emens LA Journal for ImmunoTherapy of Cancer

Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors (2019) Piha-Paul SA, Hann CL, French CA, Cousin S, Brana I, Cassier PA, Moreno V, de Bono JS, Duckworth Harward S, Ferron-Brady G, Barbash O, Wyce A, Wu Y, Horner T, Annan M, Parr NJ, Prinjha RK, Carpenter CL, Hilton J, Hong DS, Hass NB, Markowski MC, Dhar A, ODwyer PJ, Shapiro GI JNCI Cancer Spectrum

Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study. (2019) Schafer PH, Kivitz AJ, Ma J, Korish S, Sutherland D, Li L, Azaryan A, Kosek J, Adams M, Capone L, Hur EM, Hough DR, Ringheim GE Rheumatology and Therapy

Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats. (2019) Komninou D, Malloy VL, Zimmerman JA, Sinha R, Richie JP Jr GeroScience

A Machine-Learning Approach to Identify a Prognostic Cytokine Signature That Is Associated With Nivolumab Clearance in Patients With Advanced Melanoma. (2019) Wang R, Shao X, Zheng J, Saci A, Qian X, Pak I, Roy A, Bello A, Rizzo JI, Hosein F, Moss RA, Wind-Rotolo M, Feng Y Clinical Pharmacology and Therapeutics

Novel Biomarkers for Change in Renal Function in People With Dysglycemia. (2019) Gerstein HC, Pare G, McQueen MJ, Lee SF, Bangdiwala SI, Kannt A, Hess A, ORIGIN Trial Investigators Diabetes Care

Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma. (2019) Wang R, Zheng J, Shao X, Ishii Y, Roy A, Bello A, Lee R, Zhang J, Wind-Rotolo M, Feny Y Journal for ImmunoTherapy of Cancer

Serum Alpha-1 Antitrypsin Levels and the Clinical Course of Chronic Obstructive Pulmonary Disease (2019) Takei N, Suzuki M, Makita H, Konno S, Shimizu K, Kumura H, Kumura H, Nishimura M International Journal of Chronic Obstructive Pulmonary Disease

Blood-based protein mediators of senility with replications across biofluids (2019) Royall DR, Palmer RF, The Alzheimers Disease Neuroimaging Initiative Brain Communications

Amygdalar activity predicts future incident diabetes independently of adiposity (2019) Osborne MT, Ishai A, Hammad B, Tung B, Wang Y, Baruch A, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A Psychoneuroendocrinology

Adjustment of the multi-biomarker disease activity score to account for age, sex and adiposity in patients with rheumatoid arthritis (2019) Curtis JR, Flake DD 2nd, Weinblatt ME, Shadick NA, Ostergaard M, Hetland ML, Brahe CH, Hwang YG, Furst DE, Strand V, Etzel CJ, Pappas DA, Wang X, Hwang CC, Sasso EH, Gutin A, Hitraya E, Lanchbury JS Rheumatology

Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis (2019) Gautam A, Muhie S, Cakraborty N, Hoke A, Donohue D, Miller SA, Hammamieh R, Jett M Metabolomics

Cortisol associated with hypometabolism across the Alzheimers disease (2019) Wirth M, Huijbers W, Lange C bioRxiv

Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases (2019) Sridhar S, Liu H, Damera G, Newbold P Respiratory Research

SOMAscan-based proteomic measurements of plasma brain natriuretic peptide are decreased in mild cognitive impairment and in Alzheimers dementia patients (2019) Begic E, Hadzidedic S, Kulaglic A, Ramic-Brkic B, Begic Z, Causevic M PLoS One

VaccHemInf Project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients (2019) Conrad A, Boccard M, Valour F, Alcazer V, Tovar Sanchez AT, Chidiac C, Laurent F, Vanhems P, Salles G, Brengel-Pesce K, Meunier B, Trouillet-Assant S, Ader F, Lyyon HEMINF Study Group BMJ Journals

Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques (2019) Sanz J, Maurizio PL, Snyder-Mackler N, Simons ND, Voyles T, Kohn J, Michopoulos V, Wilson M, Tung J, Barreiro LB bioRxiv

Early changes in immune, coagulation, and organ function after clinical and experimental polytrauma (2019) Halbgbauer Repositorium der Universit?t Ulm

A blood-based signature of cerebrospinal fluid A?1-42 status (2019) Goudey B, Fung BJ, Schieber C, Faux NG, Alzheimers Disease Metabolomics Consortium, Alzheimers Disease Neuroimaging Initiative Scientific Reports

Exploring and redefining Autoimmune polyendocrine syndrome type 1 (2019) Bruserud Skipnes Kommunikasjon, University of Bergen

A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity (2019) Williams PT, Bergeron N, Chiu S, Krauss RM Lipids in Health and Disease

Maternal deprivation increases microglial activiation and neuroinflammatory markers in the prefrontal cortex and hippocampus of infant rats (2019) Giridharan VV, Gislaine ZR, Selvaraj S, Scaini G, Barichello T, Quevedo J Journal of Psychiatric Research

Performance of a clinical/proteomic panel to predict obstructive peripheral artery disease in patients with and without diabetes (2019) McCarthy CP, Shrestha S, Ibrahim N, van Kimmenade RRJ, Gaggin HK, Mukai R, Magaret C, Barnes G, Rhyne R, Garasic JM, Januzzi JL Open Heart

Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation. (2019) Haraden CA, Huebner JL, Hsueh MF, Li YJ, Kraus VB Arthritis Research & Therapy

Applying modern Omic technologies to the Neuronal Ceroid Lipofuscinoses. (2019) Kline RA, Wishart TM, Mills K, Heywood WE BBA - Molecular Basis of Disease

Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome. (2019) Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Pare G Circulation

Identification of Novel Causal Blood Biomarkers Linking Metabolically Favorable Adiposity With Type 2 Diabetes Risk (2019) Pigeyre M, Sjaarda J, Mao S, Chong M, Hess S, Yusuf S, Gerstein H, Pare G Diabetes Care

Immune function as predictor of infectious complications and clinical outcome in patients undergoing solid organ transplantation (the ImmuneMo:SOT study): a prospective non-interventional observational trial. (2019) Drabe CH, Sorensen SS, Rasmussen A, Perch M, Gustafsson F, Rezahosseini O, Lundgren JD, Osrowski SR, Nielson SD BMC Infectious Diseases

Key inflammatory pathway activations in the MCI stage of Alzheimers disease (2019) Pillai JA, Maxwell S, Bena J, Bekris LM, Rao SM, Chance M, Lamb BT, Leverenz JB Annals of Clinical and Translational Neurology

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. (2019) Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z, Lim SO , Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y, Nie L, Hsu JL, Li H, Ye Q, Hassan MM, Amin HM, Kaseb AO, Lin X, Wang SC, Hung MC The Journal of Clinical Investigation

Plasma cortisol is associated with cerebral hypometabolism across the Alzheimer?s disease spectrum (2019) Wirth M, Lange C, Huijbers W, for the Alzheimers Disease Neuroimaging Initiative Neurobiology of Aging

T cell phenotypes are associated with serum IgE levels in Amish and Hutterite children (2019) Hrusch CL, Stein MM, Gozdz J, Holbreich M, Von Mutius E, Vercelli D, Ober C, Sperling AI Journal of Allergy and Clinical Immunology

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease. (2019) Fajgenbaum DC, Langan RA, Sada Japp A, Patridge HL, Pierson SK, Singh A, Arenas DJ, Ruth JR, Nabel CS, Stone K, Okumura M, Schwarer A, Jose FF, Hamerschlak N, Wertheim GB, Jordan MB, Cohen AD, Krymskaya V, Rubenstein A, Betts MR, Kambayashi T, van Rhee F, Uldrick TS The Journal of Clinical Investigation

Hypothesis: cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathology (2019) Meyer PF, Savard M, Poirier J, Morgan D, Breitner J, for the Alzheimers Disease Neuroimaging Initiative Alzheimers & Dementia

The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation. (2019) Leiter O, Bernas SN, Seidemann S, Overall RW, Horenburg C, Kowal S, Kempermann G, Walker TL Scientific Reports

Morphological and Molecular Changes in Juvenile Normal Human Fibroblasts Exposed to Simulated Microgravity. (2019) Buken C, Sahana J, Corydon TJ, Melnik D, Bauer J, Wehland M, Kruger M, Balk S, Abuagela N, Infanger M, Grimm D Scientific Reports

Innate Immune Cells and C-Reactive Protein in Acute First-Episode Psychosis and Schizophrenia: Relationship to Psychopathology and Treatment (2019) Steiner J, Frodl T, Schiltz K, Dobrowolny H, Jacobs R, Fernandes BS, Guest PC, Meyer-Lotz G, Borucki K, Bahn S, Bogerts B, Falkai P, Bernstein HG Schizophrenia Bulletin

Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults. (2019) Diniz BS, Reynolds Iii CF, Sibille E, Bot M, Penninx BWJH Translational Psychiatry

Plasma total fibroblast growth factor 23 levels are associated with acute kidney injury and mortality in children with acute respiratory distress syndrome. (2019) Hanudel MR, Zinter MS, Chen L, Gala K, Lim M, Guglielmo M, Deshmukh T, Vangala S, Matthay M, Sapru A PLoS One

Therapy with 2O methly phosphorothioate antisense oligonucleotides causes reversible proteinuria by inhibiting renal protien reabsorption (2019) Janssen MJ, Nieskens TTG, Steevels TAM, Caetano-Pinto P, den Braanker D, Mulder M, Ponstein Y, Jones S, Masereeuw R, den Besten C, Wilmber MJ Molecular Therapy Nucleic Acids

Vaccine Protection against Multidrug-Resistant Klebsiella pneumoniae in a Nonhuman Primate Model of Severe Lower Respiratory Tract Infection (2019) Malachowa N, Kobayashi SD, Porter AR, Freedman B, Hanley PW, Lovaglio J, Saturday GA, Gardner DJ, Scott DP, Griffin A, Cordova K, Long D, Rosenke R, Sturdevant DE, Bruno D, Martens C, Kreiswirth BN, DeLeo FR mBio

Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant (2019) Herlin T, Jorgensen SE, Host C, Mitchell PS, Christensen MH, Lausten M, Larsen DA, Schmidt FI, Christiansen M, Mogensen TH Rheumatology

Plasma sex hormone-binding globulin predicts neurodegeneration and clinical progression in prodromal Alzheimers disease (2019) Wu W, Su BJ, Shen XN, Bi YL, Tan CC, Li JQ, Dong Q, Tan L, Alzheimers Disease Neuroimaging Initiative, Yu JT Cognitive Neuroscience

A clinical, proteomics, and artificial intelligence-driven model to predict acute kidney injury in patients undergoing coronary angiography (2019) Nasrien E. Ibrahim, Cian P. McCarthy, Shreya Shrestha, Hanna K. Gaggin, Renata Mukai, Craig A. Magaret, Rhonda F. Rhyne and James L. Januzzi, Jr Clinical Cardiology

Biomarker panels associated with progression of renal disease in type 1 diabetes. (2019) Colombo M, Valo E, McGurnaghan SJ, Sandholm N, Blackbourn LAK, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM Diabetologia

A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer. (2019) Rammensee HG, Wiesmuller KH, Chandran PA, Zelba H, Rusch E, Gouttefangeas C, Kowalewski DJ, Di Marco M, Haen SP, Walz JS, Gloria YC, Bodder J, Schertel JM, Tunger A, Muller L, Kiebler M, Wehner R, Schmitz M, Jakobi M, Schneiderhan-Marra N, Klein R, Laske K, Artzner K, Backert L, Schuster H, Schwenck J, Weber ANR, Pichler BJ, Kneilling M, la Fougere C, Forchhammer S, Metzler G, Bauer J, Weide B, Schippert W, Stevanovic S, Loffler MW Journal for ImmunoTherapy of Cancer

Inflammatory parameters associated with systemic reactogenicity following vaccinatino with adjuvanted hepatitis B vaccines in humans (2019) Burny W, Marchant A, Herve C, Callegaro A, Caubet M, Fissette L, Gheyle L, Legrand C, Ndour C, Tavares Da Silva F, van der Most R, Willems F, Didierlaurent AM, Yarzabal J, ECR-008 study group Vaccine

Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak (2019) Gramaglia I, Velez J, Chang YS, Caparros-Wanderley W, Combes V, Grau G, Stins MF, van der Heyde HC PLoS One

TGFb receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer (2019) Melisi D, Garcia-Carbonero R, Macarulla T, Pezet D, Deplangue G, Fuchs M, Trojan J, Kozloff M, Simionato F, Cleverly A, Smith C, Wang S, Man M, Driscoll KE, Estrem ST, Lahn MMF, Benhadji KA, Tabernero J Cancer Chemotherapy and Pharmacology

External Validation of a Pre-Transplant Biomarker Model (REVERSE) Predictive of Renal Recovery after Liver Transplantation (2019) Levitsky J, Asrani SK, Abecassis M, Ruiz R, Jennings LW, Klintmalm G Hepatology

Biomarkers of Community-Acquired Pneumonia: A Key to Disease Diagnosis and Management (2019) Savvateeva EN, Rubina AY, Gryadunov DA BioMed Research International

VEGF-A from Granuloma Macrophages Regulates Granulomatous Inflammation by a Non-angiogenic Pathway during Mycobacterial Infection (2019) Harding JS, Herbath M, Chen Y, Rayasam A, Ritter A, Csoka B, Hasko G, Michael IP, Faby Z, Nagy A, Sandor M Cell Reports

Increased serum levels of leptin and insulin in both schizophrenia and major depressive disorder: A cross-disorder proteomics analysis (2019) Cakici N, Bot M, Lamers F, Janssen T, van der Haan L, Bahn S, Penninx BWJH, van Beveren NJM European Neuropsychopharmacology

Impaired kidney structure and function in spinal muscular atrophy (2019) Nery FC, Siranosian JJ, Rosales I, Deguise MO, Sharma A, Muhtaseb AW, Nwe P, Johnstone AJ, Zhang R, Fatouraei M, Huemer N, Alves CRR, Kothary R, Swoboda KJ Neurology Genetics

Targeting the CD40-CD154 Signaling Pathway for Treatment of Autoimmune Arthritis. (2019) Lai JH, Luo SF, Ho LJ Cells

Type I Interferon Predicts an Alternate Immune System Phenotype in Systemic Lupus Erythematosus (2019) Thanarajasingam U, Muppirala AN, Jensen MA, Ghodke-Puranik Y, Dorschner JM, Vsetecka DM, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold TB ACR Open Rheumatology

Biomarkers of diabetic kidney disease (2018) Colhoun HM, Marcovecchio ML Diabetologia

Effects of canagliflozin versus glimepiride on adipokines and in inflammatory biomarkers in type 2 diabetes (2018) Garvey WT, Van Gaal L, Leiter LA, Vijapurkar U, List J, Cuddihy R, Ren J, Davies M Metabolism Clinical and Experimenta

S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome (2018) Wang L, Rose CD, Foley KP, Anton J, Bader-Meunier B, Brissaud P, Chedeville G, Cimaz R, Fernandez-Martin J, Guly C, Hachulla E, Harjacek M, Mackensen F, Merino R, Modesto C, Hernandez A, Pajot C, Ramanan A, Thatayatikom A, Thomee C, Vastert S, Votta B, Bertin J, Wouters CH Rheumatology

Toxoplasma gondii inactivates human plasmacytoid dendritic cells by functional mimicry of IL-10 (2018) Piotr L, Zhao Y, Singh S, Dai J, Yap GS, Fitzgerald-Bocarsly P The Journal of Immunology

Pharmacokinetics of Telavancin at Fixed Doses in Normal-Body-Weight and Obese (Classes I, II and III) Adult Subjexts (2018) Bunnell KL, Pai MP, Sikka M, Bleasdale S, Wenzler E, Danziger LH, Rodvold KA Antimicrobial Agents and Chemotherapy

Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS (2018) Putcha N, Paul GG, Azar A, Wise RA, ONeal WK, Dransfield MT, Woodruff PG, Curtis JL, Comellas AP, Drummond MB, Lambert AA, Paulin LM, Fawzy A, Kanner RE, Paine R 3rd, Han MK, Martinez FJ, Bowler RP, Barr RG, Hansel NN, SPIROMICS investigators PLoS One

Carbon nanotube and nanofiber exposure and sputum and blood biomarkers of early effect among U.S. workers (2018) Beard JD, Erdely A, Dahm MM, de Perio MA, Birch ME, Evans DE, Fernback JE, Eye T, Kodali V, Mercer RR, Bertke SJ, Schubauer-Berigan MK Environmental Internation 116 (2018)

Digital Health: a new dimension in rheumatology patient care (2018) Kataria S, Ravindran V Rheumatology International

CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype (2018) Candido J, Morton JP, Bailey P, Barry ST, Balkwill FR, Sansom OJ Cell Reports

Evaluation of plasma biomarkers of inflammation in patients with maple syrup urine disease (2018) Scaini G, Tonon T, Moura de Souza CF, Schuck PF, Ferreira GC, Quevedo J, Seda Neto J, Amorim T, Camelo Jr JS, Vitoria Barban Margutti A, Hencke Tresbach R, Sperb-Ludwig F, Boy R, V. de Medeiros PF, Schwards IVD, Luiz Streck E Journal of Inherited Metabolic Disease

Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities (2018) Putcha N, Fawzy A, Paul GG, Lambert AA, Psoter KJ, Sidhaye VK, Woo J, Wells JM, Labaki WW, Doerschuk CM, Kanner RE, Han MK, Martinez C, Paulin LM, Martinez FJ, Wise RA, ONeal WK, Barr RG, Hansei NN AnnalsATS

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort (2018) Labaki WW, Xia M, Murray S, Curtis JL, Barr RG, Bhatt SP, Bleecker ER, Hansel NN, Cooper CB, Dransfield MT, Wells JM, Hoffman EA, Kanner RE, Paine III R, Ortega VE, Peters SP, Krishnan JA, Bowler RP Respiratory Medicine

A clinical and proteomics approach to predict the presense of obstructive peripheral arterial disease (From CASABLANCA) (2018) McCarthy CP, Ibrahim NE, van Kimmenade RRJ, Gaggin HK, Simon ML, Gandhi P, Kelly N, Motiwala SR, Mukai R, Magaret CA, Barnes G, Rhyne RF, Garasic JM, Januzzi JL Jr Clin Cardiol

IL-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses (2018) van Mens LJJ, van de Sande MGH, Menegatti S, Chen S, Blijdorp ICP, de Jong HM, Fluri IA, Latuhihin TE, van Kuijk AWR, Rogge L, Yeremenko NG, Baeten DLP Arthritis Rheumatol

Networks of blood proteins in the neuroimmunology of schizophrenia (2018) Jeffries CD, Perkins DO, Fournier M, Do KQ, Cuenod M, Khadimallah I, Domenici E, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Tsuang M, Walker EF, Woods SW Transl Psychiatry

Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study (2018) Wolters F, Boender J, de Vries P, Sonneveld M, Koudstaal P, de Maat M, Franco O, Ikram M, Leebeek F, Ikram MA Scientific Reports 2018 Apr

A Multi-site In-depth Evaluation of the Qunaterix Simoa from a Users Perspective (2018) Chunyk A, Joyce A, Fischer S, Dysinger M, Mikulskis A, Jeromin A, Lawrence-Henderson R, Baker D, Yeung D The AAPS Journal 2018

Comparison of a microsphere-based platform with a multiplex flow cytometric assay for determination of circulating cytokines in the mouse (2018) Stricker-Krongrad A, Shoemake C, Zhong M, Liu J, Bouchard G BMC Clinical Pathology Jan 2018

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle (2018) Stein MM, Thempson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Morin A, Washinton C, Nicolae D, Bonnelykke K, Ober C J Allergy Clin Immunol 2018

Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease (2018) Gu JM, Yuam S, Sim D, Abe K, Liu P, Rosenbruch M, Bringmann P, Kauser K Experimental Hematology 2018

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury (2018) Proudfood A, Bayliffe A, OKane C, Wright T, Serone A, Bareille P, Brown V, Hamid U, Chen Y, Wilson R, Cordy J, Morley P, de Wildt Ruud, Elborn S, Hind M, Chilvres E, Griffiths M, Summers C, McAuley D Thorax

Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One

Allostatic load is associated with psychotic symptoms and decreases withantipsychotic treatment in patients with schizophrenia and ?rst-episodepsychosis (2018) Berger M, Juster RP, Westphal S, Amminger P, Bogerts B, Schiltz K, Bahn S, Steiner J, Sarnyai Z Psychoneuroendocrinology

Key Proteins Involed in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity (2018) Dittrich A, Grimm D, Sahana J, Bauer J, Kruger M, Infanger M, Magnusson N Cellular Physiology and Biochemistry 2018

Phase Ib Study of Glasdegib, A Hedgehog Pathway Inhibitor, in (2018) Savona M, Pollyea D, Stock W, Oehler V, Schroeder MA, Lancet J, McCloskey J, Kantarigian H, Ma WW, Shaik MN, Laird AD, Zeremski M, OConnell A, Chan G, Cortes JE Clinical Cancer Research

Embelin and its derivatives unravel the signaling, proin?ammatoryand antiatherogenic properties of GPR84 receptor (2018) Gaidarov I, Anthony T, Gatlin J, Chen X, Mills D, Solomon M, Han S, Semple G, Unett DJ Pharmacological Research

Cellular toxicity of silicon carbide nanomaterials as a function of morphology (2018) Chen F, Li G, Zhao ER, Li J, Hableel G, Lemaster JE, Bai Y, Sen GL, Jokerst JV Biomaterials

Synergistic Cytokine Effects as Apremilast Response Predictors in Patients With Psoriasis (2018) Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG Journal of Allergy and Clinical Immunology

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer (2018) Calcinottoa A, Spataro C, Zagato E, Di Mitri D, Gil V, Crespo M, De Bernardis G, Losa M, Mirenda M, Pasquini E, Rinaldi A, Sumanasuriya S, Lambros MB, Neeb A, Luciano R, Bravi CA, Nava-Rodriques D, Dolling D, Prayer-Galetti T, Ferreira A, Briganti A, Esposito A, Barry S, Yuan W, Sharp A, de Bono J, Alimonti A Nature

Standardized Immunomonitoring: Separating the Signals from the Noise (2018) Duffy D Trends in Biotechnology

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome (2018) Lal C, Hardiman G, Kumbhare S, Strange C Sleep and Breathing

Effects of an FcyRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies (2018) Stein MM, Hrusch CL, Sperling AI, Ober C Genes and Immunity

Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease (2018) Sjaarda J, Gerstein H, Chong M, Yusuf S, Meyre D, Anand SS, Hess S, Pare G Journal of the American College of Cardiology

Association between Cytokines and Functional, Hemodynamic Parameters, and Clinical Outcomes in Pulmonary Arterial Hypertension (2018) Joshi AA, Davey RA, Rao Y, Shen K, Benza R, Raina A Pulmonary Circulation

Proteomics in Chronic Arthritis - Will We Finally Have Useful Biomarkers? (2018) Kessel C, McArdle A, Verweyen E, Weinhage T, Wittkowski H, Pennington SR, Foell D Current Rheumatology Reports

Testing a multivariate proteomic panel for TBI biomarker discovery: A track-TBI pilot study (2018) Huie JR, Diaz-Arrastia R, Yue JK, Sorani M, Puccio A, Okonkwo DO, Manley GT, Ferguson AR Journal of Neurotrauma

Circulating biomarkers from the phase I trial of sirolimus and autophagy inhibition for patients with lymphangioleiomyomatosis (SAIL). (2018) Lamattina AM, Taveira-Dasilva A, Goldberg HJ, Bagwe S, Cui Y, Rosas IO, Moss J, Henske EP, El-Chemaly S Chest Journal

Altered regulation of the T-cell system in patients with CRPS (2018) Heyn J, Azad SC, Luchting B Inflammation Research

Flares in Rheumatoid Arthritis Patients with Low Disease Activity: Predictability and Association with Worse Clinical Outcomes. (2018) Bechman K, Tweehuysen L, Garrood T, Scott DL, Cope AP, Galloway JB, Ma MHY The Journal of Rheumatology

Determination of the minimally important difference (MID) in multi-biomarker disease activity (MBDA) test scores: impact of diurnal and daily biomarker variation patterns on MBDA scores (2018) Chernoff D, Scott Eastman P, Hwang CC, Flake DD 2nd, Wang X, Kivitz A, Curtis JR Clinical Rheumatology

A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis (2018) Palmer SM, Snyder L, Todd JL, Soule B, Christian R, Anstrom K, Luo Y, Gagnon R, Rosen G Chest Journal

The association of basal insulin treatment versus standard care with outcomes in anti-GAD positive and -negative subjects. A post-hoc analysis of the ORIGIN-trial (2018) Birkeland KI, Grill V, Wium C, McQueen MJ, Lopez-Jaramillo P, Lee SF, Gerstein HC Diabetes, Obesity and Metabolism

Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions (2018) Mozaffari SV, Stein MM, Magnaye KM, Nicolae DL, Ober C PLoS One

Adiponectin in Relation to Coronary Plaque Characteristics on Radiofrequency Intravascular Ultrasound and Cardiovascular Outcome (2018) Marino BCA, Buljubasic N, Akkerhuis M, Cheng JM, Garcia-Garcia HM, Regar E, van Guens RJ, Serruys PW, Boersma E, Kardys I Sociedade Brasileira De Cardiologia

Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy) (2018) Anroedh SS, Akkerhuis KM, Oemrawsingh RM, Garcia-Garcia HM, Brankovic M, Regar E, van Geuns RJ, Serruys PW, Daemen J, Van Mieghem NM, Boersma E, Kardys I Current Atherosclerosis Reports

Identifying the molecular and cellular signature of cardiac dilation following myocardial infarction (2018) Lindsey ML, Ma Y, Flynn ER, Winniford MD, Hall ME, DeLeon-Pennell KY BBA - Molecular Basis of Disease

Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants (2018) Timmers M, Ravenstijn P, Xi L, Triana-Baltzer G, Furey M, Van Hemelryck S, Biewenga J, Ceusters M, Bhattacharya A, van den Boer M, van Nueten L, de Boer P Journal of Psychopharmacology

Peripheral immune system in aging and Alzheimers disease. (2018) Cao W, Zheng H Molecular Neurodegeneartion

Serum kidney injury molecule 1 and B2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes (2018) Colombo M, Looker HC, Farran B, Hess S, Groop L, Palmer CNA, Brosnan MJ, Dalton RN, Wong M, Turner C, Ahlqvist E, Dunger D, Agakov F, Durrington P, Livingstone S, Betteridge J, McKeigue PM, Colhoun HM Diabetologia

Phase I study of BNC105P, carboplatin and gemcitabine in partially platinum-sensitive ovarian cancer patients in first or second relapse (ANZGOG-1103) (2018) Lindemann K, Beale PJ, Rossi E, Goh JC, Vaughan MM, Tenney ME, Martyn JK, Sommeijer D, Iglesias JL, Kremmidiotis G, Simpson J, Doolin E, Lavranos TC, Veillard AS, Espinoza D, Stockler MR, Rischin D Cancer Chemotherapy and Pharmacology

Phase I/II trial of combination of anti-CD3/CD7 immunotoxins for steroid-refractory acute graft-versus-host disease (2018) Groth C, van Groningen LFJ, Matos TR, Bremmers ME, Preijers FWMB, Dolstra H, Reicherts C, Schaap NPM, van Hooren EHG, IntHout J, Masereeuw R, Netea MG, Levine JE, Morales G, Ferrara JL, Blijlevens NMA, van Oosterhout YVJM, Stelljes M, van der Velden WJFM Biology of Blood and Marrow Transplantation

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients (2018) Naing A, Infante JR, Papadopoulos KP, Chan IH, Shen C, Ratti NP, Autio KA, Wong DJ, Patel MR, Ott PA, Falchook GS, Pant S, Hung A, Pekarek KL, Wu V, Adamow M, McCauley S, Mumm JB, Wong P, Van Vlasselaer P, Levegue J, Tannir NM, Oft M Cancer Cell

Elevated circulating MMP-9 is linked to increased COPD exacerbation in SPIROMICS and COPDGene (2018) Wells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R 3rd, ONeal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr RG, Woodruff P, Castaldi PJ, Gaggar A JCI Insight

Type I interferon receptor blockade with anifrolumab corrects innate and adaptive immune perturbations of SLE (2018) Casey KA, Guo X, Smith MA, Wang S, Sinibaldi D, Sanjuan MA, Wang L, Illei GG, White WI Lupus Science and Medicine

Pegbelfermin (BMS-986036), PEGlyated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study (2018) Charles ED, Neuschwander-Tetri BA, Pablo Frias J, Kundu S, Luo Y, Tirucherai GS, Christrian R Obesity (Silver Spring)

Serum Apolipoprotein E and Other Inflammatory Markers Can Identify Non-Responding Patients to a Dendritic Cell Vaccine (2018) Leeman H, Kaminska E, Green D, Bodman-Smith M, Gravett A, Bodman-Smith K, Copier J, Coulton G, Fusi A, Dalgleish AG Translational Oncology

Idiopathic Pulmonary Fibrosis: Prospective, Case-Controlled Study of Natural History and Circulating Biomarkers (2018) Raghu G, Richeldi L, Jagerschmidt A, Martin V, Subramaniam A, Ozoux ML, Esperet CA, Soubrane C Chest

Dominace rank-associated gene expression is widespread, sex-specific, and a precursor to high social status in wild male baboons (2018) Lea AJ, Akinyi MY, Nyakundi R, Mareri P, Kariuki T, Alberts SC, Archie EA, Tung J PNAS

Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort (2018) Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT, SPIROMICS investigators Respiratory Research

Testosterone, sex hormone-binding globulin and risk of cardiovascular events: A report from the Outcome Reduction with an Initial Glargine Intervention trial (2018) Wang A, Arver S, Boman K, Gerstein HC, Fu Lee S, Hess S, Ryden L, Mellbin LG Preventive Cardiology

RNA-antimicrobial peptide complexes fuel a TLR- and NETosis-mediated inflammatory cycle of neutrophil activation in psoriasis (2018) Herster F, Bittner Z, Dickhoefer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Loeffler MW, Hartl D, Freund L, Schaekel K, Heiser M, Ghoreschi K, Weber ANR bioRxiv

Drug-induced Obstructive and Retrograde Nephropathy Associated with a2u-globulin in Male Rats (2018) Jacobsen B, Freichel C, Eichinger-Chapelon A, Brink A, Hoflack JC, Albassam M, Lenz B Toxocologic Pathology

PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study (2018) Charnigo RJ, Beidler D, Rybin D, Pittman DD, Tan B, Howard J, Michelson AD, Frelinger AL II, Clark N Clinical and Translational Science

Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study (2018) Andersen M, Boesen M, Ellegaard K, Soderstrom K, Soe NH, Spee P, Morch UGW, Torp-Pedersen S, Bartels EM, Danneskiold-Samsoe B, Karlsson L, Bliddal H Plos One

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Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project (2018) Vonaesch P, Randremanana R, Gody JC, Collard JM, Giles-Vernick T, Doria M, Vigan-Womas I, Rubbo PA, Etienne A, Andriatahirintsoa EJ, Kapel N, Brown E, Huus KE, Duffy D, Finlay BB, Hasan M, Hunald FA, Robinson A, Manirakiza A, Wegener-Parfrey L, Vray M, Sansonetti PJ BMC Pediatrics

Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrom (2018) Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A American Journal of Respiratory and Critical Care Medicine

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Medial Forebrain Bundle Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Importance of BDNF and Inflammatory Cytokines (2018) Dandekar MP, Saxena A, Scaini G, Shin JH, Migut A, Giridharan VV, Zhou Y, Barichello T, Soares JC, Quevedo J, Fenoy AJ Molecular Neurobiology

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Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond (2018) Karnell JL, Amcaoglu Rider S, Ettinger R, Kolbeck R Advanced Drug Delivery Reviews

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Protein Biomarker Druggability Profiling (2017) Mani S, Cannon D, Ohls R, Oprea T, Mathias S, Ballard K, Ursu O, Bologa C J Biomed Inform

The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility. (2017) van den Broek TJ, Kremer BH, Marcondes Rezende M, Hoevenaars FP, Weber P, Hoeller U, van Ommen B, Wopereis S Genes Nutr

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Effects of Traumeel (Tr14) on recovery and inflammatory immune response after repeated bouts of exercise: a double-blind RCT. (2017) Muders K, Pilat C, Deuster V, Frech T, Kr?ger K, Pons-Kuhnemann J, Mooren FC Eur J Appl Physiol.

Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacking Superoxide Dismutase 3, Extracellular (2017) Thimraj TA, Birru RL, Mitra A, Schulz H, Leikauf GD, Ganguly K Lung

PH20 is not expressed in murine CNS and oligodendrocyte precursor cells (2017) Marella M, Ouyang J, Zombeck J, Zhao C, Huang L, Connor RJ, Phan KB, Jorge MC, Printz MA, Paladini RD, Gelb AB, Huang Z, Frost GI, Sugarman BJ, Steinman L, Wei G, Shepard HM, Maneval DC, Lapinskas PJ Ann Clin Transl Neurol

Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study (2017) Brahimaj A, Ligthart S, Ghanbari M, Ikram MA, Hofman A, Franco OH, Kavousi M, Dehghan A Eur. J. Epidemiol.

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Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. (2017) Steele NZ, Carr JS, Bonham LS, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS PloS Med.

Relation of antioxidant capacity of diet and markers of oxidative status with C-reactive protein and adipocytokines: a prospective study. (2017) Stringa N, Brahimaj A, Zaciragic A, Dehghan A, Ikram MA, Hofman A, Muka T, Kiefte-de Jong JC, Franco OH Metab.

Impact of Maternal antibodies and infant gut microbiota on the immunogenicity of rotacirus vaccines in African, Indian, and European infants: protocol for a prospective cohort study. (2017) Sindhu KN, Cunliffe N, Peak M, Turner M, Darby A, Grassly N, Gordon M, Dube Q, Babji S, Praharaj I, Verghese V, Iturriza-Gomara M, Kang G BMJ

Immunodepression after CPB: Cytokine dynamics and clinics after pediatric cardiac surgery ? A prospective trial (2017) Justus G, Walker C, Rosenthal LM, Berger F, Miera O, Schmitt KR Cytokine

A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis after Methotrexate Failure (2017) Hambardzumyan K, Saevarsdottir S, Forslind K, Petersson IF, Wallman JK, Ernestam S, Bolce RJ, van Vollenhoven RF Arthritis Rheumatol

The Orally Available Selective Axl Inhibitor BGB324 Induces Diversification of the Immune Repertoire and Specific Changes in Plasma Biomarker Profiles (2017) Loges S, Gjertsen BT, Heuser M, Chromik J, Ben-Batalla I, Akyuz N, Micklem D, Brown A, Lorens J, Yule M, Kebenko M, Janning M, Binder M, Fiedler W, Cortes J Blood

A Multibiomarker Disease Activity Score for Rheumatoid Arthritis Predicts Radiographic Joint Damage in the BeSt Study (2017) Markusse IM, Dirven L, van den Broek M, Bijkerk C, Han K.H, Ronday H.K, Bolce R, Sasso E, Kerstens P, Lems WF, Huizinga T, and Allaart CF J Rheumatol.

The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden. CETP mice (2017) Landlinger C, Pouwer MG, Juno C, van der Hoorn J, Pieterman EJ, Jukema JW, Staffler G, Princen H, and Galabova, G Eur. Heart J.

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The REAnimation Low Immune Status Markers (REALISM) project: a protocol for broad characterisation and follow-up of injury-induced immunosuppression in intensive care unit (ICU) critically ill patients (2017) Rol ML, Venet F, Rimmele T, Moucadel V, Cortez P, Quemeneur L, Gardiner D, Griffiths A, Pachot A, Textoris J, Monneret G, On behalf of the REALISM study group BMJ Open

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. (2017) Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T Nature

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Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension. (2017) Nishida K, Brune KA, Putcha N, Mandke P, ONeal WK, Shade D, Srivastava V, Wang M, Lam H, An SS, Drummond MB, Hansel NN, Robinson DN, Sidhaye VK. Am J Physiol Lung Cell Mol Physiol

Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension? (2017) Tonelli AR, Fares WH, Dakkak W, Rao Y, Zhou X, Dweik RA Pulm Circ

Altered Expression of MicroRNAs in Rheumatoid Arthritis (2017) Tavasolian E, Abdollahi E, Rezaei R, Momtazi AA, Henrotin Y, Sahebkar A J. Cell. Biochem.

Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: Applications of a proteomic informed genomic approach (2017) Nassan M, Jia Y, Jenkins G, Colby C, Feeder S, Choi D, Veldic M, McElroy SL, Bond DJ, Weinshilboum R, Biernacka JM, Frye MA J Psychiatr Res

Proteomics to predict the response to tumour necrosis factor-a inhibitors in rheumatoid arthritis using a supervised cluster-analysis based protein score (2017) Cuppen BVJ, Fritsch-Stork RDE, Eekhout, W de Jager I, Marijnissen AC, Bijlsma JWJ, Custers M, Van Laar JM, Lafeber FPJG, Welsing PMJ & on behalf of all Society for Rheumatology Research Utrecht (SRU) investigators Scand J Rheumatol

Prophylactic Treatment with Cerium Oxide Nanoparticles Attenuate Hepatic Ischemia Reperfusion Injury in Sprague Dawley Rats. (2017) Manne NDPK, Arvapalli R, Graffeo VA, Bandarupalli VVK, Shokuhfar T, Patel S, Rice KM, Ginjupalli GK, Blough ER Cell Physiol Biochem

Complexity of Macrophage Migration Inhibitory Factor (MIF) and Other Angiogenic Biomarkers Profiling in Pulmonary Arterial Hypertension. (2017) Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee P, Fares W Pulm Circ.

Clinical Features of Psoriatic Arthritis: a Comprehensive Review of Unmet Clinical Needs. (2017) McArdle A, Pennington S, FitzGerald O Clin Rev Allergy Immunol.

Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks (2017) Gadad BS, Jha MK, Czysz A, Furman JL, Mayes TL, Emslie MP, Trivedi MH J Affect Disord

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A randomised, placebo-controlled trial of anti-interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease. (2017) Calverley PMA, Sethi S, Dawson M, Ward CK, Finch DK, Penney M, Newbold P, van der Merwe R Respir Res.

Nintedanib macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis (2017) Huang J, Maier C, Zhang Y, Soare A, Dees C, Beyer C, Harre U, Chen CW, Distler O, Schett G, Wollin L, Distler JHW Ann Rheum Dis.

Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine. (2017) Warnke E, Pietsch J, Kopp S, Bauer J, Sahana J, Wehland M, Kr?ger M, Hemmersbach R, Infanger M, L?tzenberg R, Grimm D Cell Physiol Biochem.

IL-18 associated with lung lymphoid aggregates drives IFN? production in severe COPD. (2017) Briend E, Ferguson GJ, Mori M, Damera G, Stephenson K, Karp NA, Sethi S, Ward CK, Sleeman MA, Erjef?lt JS, Finch DK Respir Res.

Assessment of Proteomic Measures Across Serious Psychiatric Illness. (2017) Schulz SC, Overgaard S, Bond DJ, Kaldate R. Clin Schizophr Relat Psychoses

Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints. (2017) Phillips B, Titz B, Kogel U, Sharma D, Leroy P, Xiang Y, Vuillaume G, Lebrun S, Sciuscio D2, Ho J, Nury C2, Guedj E, Elamin A, Esposito M, Krishnan S, Schlage WK, Veljkovic E, Ivanov NV, Martin F, Peitsch MC, Hoeng J, Vanscheeuwijck P Food Chem Toxicol.

In Vivo Toxicity Assessment of Occupational Components of the Carbon Nanotube Life Cycle To Provide Context to Potential Health Effects. (2017) Bishop L, Cena L, Orandle M, Yanamala N, Dahm MM, Birch ME, Evans DE, Kodali VK, Eye T1, Battelli L, Zeidler-Erdely PC, Casuccio G, Bunker K, Lupoi JS, Lersch TL, Stefaniak AB, Sager T, Afshari A, Schwegler-Berry D, Friend S, Kang J, Siegrist KJ, Mitchell CA, Lowry DT, Kashon ML, Mercer RR, Geraci CL, Schubauer-Berigan MK, Sargent LM, Erdely A. ACS Nano.

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Altered Immune Activation and IL-23 Signaling in Response to Candida albicans in Autoimmune Polyendocrine Syndrome Type 1 (2017) Bruserud O, Bratland E, Hellesen A, Delaleu N, Reikvam H, Oftedal BE, and Wolff A Front Immunol.

Intrathecal 2-hydroxypropyl-?-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial. (2017) Ory DS, Ottinger EA, Farhat NY, King KA, Jiang X, Weissfeld L, Berry-Kravis E, Davidson CD, Bianconi S, Keener LA, Rao R, Soldatos A, Sidhu R, Walters KA, Xu X, Thurm A, Solomon B, Pavan WJ, Machielse BN, Kao M, Silber SA, McKew JC, Brewer CC, Vite CH, Walkley SU, Austin CP, Porter FD Lancet

Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer. (2017) Yeh CY, Adusumilli R, Kullolli M, Mallick P, John EM, Pitteri SJ Biomark Res.

Perspectives on using a multiplex human kidney safety biomarker panel to detect cisplatin-induced tubular toxicity in male and female Cynomolgus monkeys. (2017) Chen Y, Dale Thurman J, Kinter LB, Bialecki R, Eric McDuffie J Toxicol Appl Pharmacol.

Biomarker-guided stratification of autoimmune patients for biologic therapy. (2017) Ivison S, Des Rosiers C, Lesage S, Rioux JD, Levings MK. Curr Opin Immunol.

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Randomized clinical study of safety, pharmacokinetics, andpharmacodynamics of RIPK1 inhibitor GSK2982772 in healthyvolunteers (2017) Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JE, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang M Pharmacol Res Perspect.

Biosynthesis of cerium oxide nanoparticles and their effect on lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction in male Sprague Dawley rats. (2017) Chen G, Xu Y Mater Sci Eng C Mater Biol Appl.

The role of anxious distress in immune dysregulation in patients with major depressive disorder. (2017) Gaspersz R, Lamers F, Wittenberg G, Beekman ATF, van Hemert AM, Schoevers RA, Penninx BWJH Transl Psychiatry

Inflammatory profile analysis reveals differences in cytokine expression between smokers, moist snuff users, and dual users compared to non-tobacco consumers. (2017) Sgambato JA, Jones BA, Caraway JW, Prasad GL Cytokine

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. (2017) Steggerda SM, Bennett MK, Chen J, Emberley E, Huang T, Janes JR, Li W, MacKinnon AL, Makkouk A, Marguier G, Murray PJ, Neou S, Pan A, Parlati F, Rodriguez MLM, Van de Velde LA, Wang T, Works M, Zhang J, Zhang W, Gross MI J Immunother Cancer

The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia. (2017) Quiros-Roldan E, Castelli F, Lanza P, Pezzoli C, Vezzoli M; Inflammation in HIV Study Group, Biasiotto G, Zanella I J Transl Med.

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Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CR-8 ISS space mission - The SPHEROIDS project. (2017) Pietsch J, Gass S2, Nebuloni S, Echegoyen D, Riwaldt S, Baake C, Bauer J, Corydon TJ, Egli M, Infanger M, Grimm D Biomaterials

CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. (2017) Fardo DW, Katsumata Y, Kauwe JS, Deming Y, Harari O, Cruchaga C; Alzheimers Disease Neuroimaging Initiative, Nelson PT Exp Gerontol

Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Ployunsaturated Fatty Acids in a Dose Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. (2017) Lefort N, LeBlanc R, Surette M Nutrients

Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Undergoing Diagnostic Coronary Angiography (From the Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA] Study) (2017) McCarthy CP, Van Kimmenade R, Gaggin HK, Simon ML, Ibrahim NE, Gandhi P, Kelly N, Motiwala SR, Belcher AM, Harisiades J, Magaret CA, Rhyne RF, Januzzi Jr. JL Am J Cardiol

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study (2017) Maher TM, Oballa E, Simpson JK, Porte J, Habgood A, Fahy WA, Flynn A, Monlyneaux PL, Braybrooke R, Divyateja H, Parfrey H, Rassl D, Russell AM, Saini G, Renzoni EA, Duggan AM, Hubbard R, Wells AU, Lukey PT, Marshall RP, Jenkins RG Lancet Respir Med

Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy (2017) Gnjatic S, Bronte V, Brunet LR, Butler MO, Disis ML, Galon J, Hakansson LG, Hanks BA, Karanikas V, Khleif SN, Kirkwood JM, Miller LD, Schendel DJ, Tanneau I, Wigginton JM and Butterfield LH J Immunother Cancer

Vitamin D-deficiency and sex-specific dysregulation of placental inflammation (2017) Liu NQ, Larner DP, Yao Q, Chun RF, Ouyang Y, Zhou R, Tamblyn JA, Wagner CL, Hewison M J Steroid Biochem Mol Biol.

Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimers disease spectrum. (2017) Swanson A, Willette AA; Alzheimer?s Disease Neuroimaging Initiative. Brain Behav Immun.

A multivariate predictive modeling approach reveals a novel CSF peptide signature for both Alzheimer ?s Disease state classification and for predicting future disease progression (2017) Llano DA, Bundela S, Mudar RA, Devanarayan V Plos One

Changes in IL-17A, macrophage-derived chemokine and adiponectin following treatment of psoriasis with calcipotriol plus betamethasone dipropionate aerosol foam: results from the PSO-ABLE study. (2017) R?pke M, Bulai Livideanu C, Kaldate R, Snel A, Paul C Br J Dermatol.

Inflammatory proteins in nasal lavage of workers exposed to occupational agents. (2017) Castano R, Yucesoy B, Johnson VJ, Castellanos L, Cartier A Clin Exp Allergy

Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons. (2017) Parviainen L, Dihanich S, Anderson GW, Wong AM, Brooks HR, Abeti R, Rezaie P, Lalli G, Pope S, Heales SJ, Mitchison HM, Williams BP, Cooper JD Acta Neuropathol Commun.

A Potential Endophenotype for Alzheimers Disease: Cerebrospinal Fluid Clusterin (2016) Deming Y, Xia J, Cai Y, Lord J, Holmans P, Bertelsen S, Holtzman D, Morris JC, Bales K, Pickering EH, Kauwe J, Goate A, Cruchaga C Neurobiology of Aging

A Semi-Mechanism Approach Based on Mri and Proteomics for Prediction of Conversion from Mild Cognitive Impairment to Alzheimer?s Disease (2016) Liu H, Zhou X, Jiang H, He H, Liu X Scientific Reports

Early Role of Vascular Dysregulation on Late-Onset Alzheimers Disease Based on Multifactorial Data-Driven Analysis (2016) Iturria-Medina Y, Sotero RC, Toussaint PJ, Mateos-Perez JM, Evans AC, The Alzheimers Disease Neuroimaging Initiative Nature Communications

Loss of Immune Tolerance Is Controlled by Icos in Sle1 Mice (2016) Mittereder N, Kuta E, Bhat G, Dacosta K, Cheng LI, Herbst R, Carlesso G Journal of Immunology

Contribution of Staphylococcus Aureus Coagulases and Clumping Factor a to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection (2016) Malachowa N, Kobayashi SD, Porter AR, Braughton KR, Scott DP, Gardner DJ, Missiakas DM, Schneewind O, Deleo FR PLoS ONE

The Different Effects of Strength and Endurance Exercise Training on Cox-2 and Mpges-Expression in Mouse Brain Are Independent of Peripheral Inflammation (2016) Kr?ger K, Bredeh?ft J, Mooren FC, Rummel C Journal of Applied Physiology

Endometriosis Leads to an Increased Trefoil Factor 3 Concentration in the Peritoneal Cavity but Does Not Alter Systemic Levels (2016) Henze D, Doecke W-D, Hornung D, Agueusop I, Von Ahsen O, Machens K, Schmitz AA, Gashaw I Reproductive Sciences

Comprehensive Systems Biology Analysis of a 7-Month Cigarette Smoke Inhalation Study in C57bl/6 (2016) Ansari S, Baumer K, Bou? S, Dijon S, Dulize R, Ekroos K, Elamin A, Foong C, Guedj E, Hoeng J, Ivanov NV, Krishnan S, Leroy P, Martin F, Merg C, Peck MJ, Peitsch MC, Phillips B, Schlage WK, Schneider T, Talikka M, Titz B, Vanscheeuwijck P, Veljkovic E, Vihervaara T, Vuillaume G, Woon CQ Scientific Data

The Relationship between Complement Factor C3, Apoe ?4, Amyloid and Tau in Alzheimer?s Disease (2016) Bonham LW, Desikan RS, Yokoyama JS Acta Neuropathologica Communications

Variants in Ccl16 Are Associated with Blood Plasma and Cerebrospinal Fluid Ccl16 Protein Levels (2016) Ebbert MTW, Staley LA, Parker J, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JSK BMC Genomics

Blood Biomarkers of Chronic Inflammation in Gulf War Illness (2016) Johnson GJ, Slater BCS, Leis LA, Rector TS, Bach RR PLoS ONE

Identification of Plexin A4 as a Novel Clusterin Receptor Links Two Alzheimers Disease Risk Genes (2016) Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD Human Molecular Genetics

Vagus Nerve Stimulation Inhibits Cytokine Production and Attenuates Disease Severity in Rheumatoid Arthritis (2016) Koopman FA, Chavan SS, Miljko S, Grazio S, Sokolovic S, Schuurman PR, Mehta AD, Levine YA, Faltys M, Zitnik R, Tracey KJ, Tak PP PNAS

Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT (2016) Muders K, Pilat C, Deuster V, Frech T, Kruger K, Pons-Kuhnemann J, Mooren F-C Mediators of Inflammation

Genome-Wide Association Study of Prolactin Levels in Blood Plasma and Cerebrospinal Fluid (2016) Staley LA, Ebbert MTW, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JSK BMC Genomics

Serum Proteomic Profiles of Depressive Subtypes (2016) Lamers F, Bot M, Jansen R, Chan MK, Cooper JD, Bahn S, Penninx BWJH Translational Psychiatry

Peripheral Blood Cell Gene Expression Diagnostic for Identigying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures (2016) Kurian SM, Novais M, Whisenant T, Gelbart T, Buxbaum JN, Kelly JW, Coelho T, Salomon DR Theranostics

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children (2016) Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, Von Mutius E, Vercelli D, Ober C, Sperling AI New England Journal of Medicine

Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (Am0010) in Patients with Advanced Solid Tumors (2016) Naing A, Papadopoulos KP, Autio KA, Ott PA, Patel MR, Wong DJ, Falchook GS, Pant S, Whiteside M, Rasco DR, Mumm JB, Chan IH, Bendell JC, Bauer TM, Colen RR, Hong DS, Van Vlasselaer P, Tannir NM, Oft M, Infante JR Journal of Clinical Oncology

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses (2016) Urrutia A, Duffy D, Rouilly V, Posseme C, Djebali R, Illanes G, Libri V, Albaud B, Gentien D, Piasecka B, Hasan M, Fontes M, Quintana-Murci L, Albert Matthew l, Abel L, Alcover A, Astrom K, Bousso P, Bruhns P, Cumano A, Demangel C, Deriano L, Di santo J, Dromer F, Eberl G, Enninga J, Fellay J, Freitas A, Gelpi O, Gomperts-Boneca I, Hercberg S, Lantz O, Leclerc C, Mouquet H, Pellegrini S, Pol S, Rogge L, Sakuntabhai A, Schwartz O, Schwikowski B, Shorte S, Soumelis V, Tangy F, Tartour E, Toubert A, Ungeheuer M-N, Quintana-Murci L, Albert Matthew Cell Reports

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Phase 1 study of the anti-vascular endothelial growth factor receptor 3 monoclonal antibody LY3022856/IMC-3C5 in patients with advanced and refractory solid tumors and advanced colorectal cancer (2016) Saif MW, Knost JA, Chiorean EG, Kambhampati SR, Yu D, Pytowski B, Qin A, Kauh JS, ONeil BH Cancer Chemother Pharmacol

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Pathogen and Host Response Dynamics in a Mouse Model of Borrelia hermsii Relapsing Fever (2016) Crowder CD, Langeroudi AG, Estabragh AS, Lewis ERG, Marcsisin RA, Barbour AG Veterinary Sciences

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A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. (2016) Jimeno A, Posner MR, Wirth LJ, Saba NF, Cohen RB, Popa EC, Argiris A, Grossmann KF, Sukari A, Wilson D, Zhang X, Sun J, Glasser C, Attie KM, Sherman ML, Pandya SS, Weiss J. Cancer

Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli. (2016) S?derlund S, Christiansson L, Persson I, Hjorth-Hansen H, Richter J, Simonsson B, Mustjoki S, Olsson-Str?mberg U, Loskog A. Leuk Res

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Do Single or Sequential Measurements of Leptin and Adiponectin in Plasma Have Prognostic Value in Pulmonary Arterial Hypertension? (2016) Tonelli AR, Fares WH, Dakkak W, Rao Y, Dweik RA Pulmonary Circulation

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke (2016) Wong ET, Kogel U, Veljkovic E, Martin F, Xiang Y, Boue S, Vuillaume G, Leroy P, Guedj E, Rodrigo G, Ivanov NV, Hoeng J, Peitsch MC, Vanscheeuwijck P. Regul Toxicol Pharmacol.

Biological stress systems, adverse life events and the improvement of chronic multi-site musculoskeletal pain across a 6-year follow-up. (2016) Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, de Geus EJ, Dekker J, Penninx BW. J Pain

Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke (2016) Oviedo A, Lebrun S, Kogel U, Ho J, Tan WT, Titz B, Leroy P, Vuillaume G, Bera M, Martin F, Rodrigo G, Esposito M, Dempsey R, Ivanov NV, Hoeng J, Peitsch MC, Vanscheeuwijck P. Regul Toxicol Pharmacol.

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Selective p38a MAP kinase/MAPK14 inhibition in enzymatically-modified LDL-stimulated human monocytes: implications for atherosclerosis. (2016) Cheng F, Twardowski L, Fehr S, Aner C, Schaeffeler E, Joos T, Knorpp T, Dorweiler B, Laufer S, Schwab M, Torzewski M. FASEB J

Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application. (2016) Vasquez MM, Hu C, Roe DJ, Chen Z, Halonen M, Guerra S BMC Med Res Methodol

Investigative Nonclinical Cardiovascular Safety and Toxicology Studies with BMS-986094, an NS5b RNA-Dependent RNA Polymerase Inhibitor (2016) Gill M, Horn K, Hennan J, White R, Bounous D, Clark S, Megill JR, Janovitz E, Davies M, Sanderson T, Graziano M. Toxicol Sci

Social status alters immune regulation and response to infection in macaques (2016) Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J Science

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Oxidative stress in drug-na?ve first episode patients with schizophrenia and major depression: effects of disease acuity and potential confounders (2016) Jordan W, Dobrowolny H, Bahn S, Bernstein HG, Brigadski T Eur Arch Psychiatry Clin Neurosci

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Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease (2016) Nakagawa N, Barron L, Gomez IG, Johnson BG, Roach AM, Kameoka S, Jack RM, Lupher ML, Gharib SA, Duffield JS JCI Insight

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin (2016) Gerstein HC, Pare G, Hess S, Ford RJ, Sjaarda J, Raman K, McQueen M, Lee S, Haenel H, Steinberg GR; ORIGIN Investigators. Diabetes Care

Mindfulness-Based Cognitive Therapy Associated with Decreases in C-Reactive Protein in Major Depressive Disorder: A Pilot Study (2016) Eisendrath SJ, Gillung E, Hartzler A, James-Myers M, Wolkowitz O, Sipe W, Ramanatham D, Delucchi K J. Altern. Complement. Med.

Serum biomarkers and changes in clinical/MRI evidence of golimumab-treated patients with ankylosing spondylitis: results of the randomized, placebo-controlled GO-RAISE study (2016) Inman RD, Baraliakos X, Hermann KA, Braun J, Deodhar A, Heijde D, Xu S, and Hsu B Arthritis Res Ther.

Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study (2016) Brahimaj A, Ligthart S, Ikram MA, Hofman A, Franco OH, Sijbrands EJ, Kavousi M, Dehghan A Diabetes Care

Association of the multi-biomarker disease activity score with joint destruction in patients with rheumatoid arthritis receiving tumor necrosis factor-alpha inhibitor treatment in clinical practice (2016) Hirata S, Li W, Kubo S, Fukuyo S, Mizuno Y, Hanami K, Sawamukai N, Yamaoka K, Saito K, Defranoux NA, Tanaka Y Mod Rheumatol

Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritis: results from the SWEFOT trial (2016) Hambardzumyan K, Bolce RJ, Saevarsdottir S, Forslind K, Wallman JK, Cruickshank SE, Sasso E, Chernoff D and Van Vollenhoven R RMD

Biomarkers in Rheumatoid Arthritis, what is new? (2016) Gavrila BI, Ciofu C, and Stoica V J Med Life

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Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant (2016) Felsky D, De Jager PL, Schneider JA, Arfanakis K, Fleischman DA, Arvanitakis Z, Honer WG, Pouget JG, Mizrahi R, Pollock BG, Kennedy JL, Bennett DA, Voineskos AN J Cereb Blood Flow Metab

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits (2016) Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, Alzheimer?s Disease Neuroimaging Initiative (ADNI), Holtzman D, Morris JC, Bales K, Pickering EH, Lee J, Heitsch L, Kauwe J, Goate A, Piccio L, Cruchaga C Scientific Reports

Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination (2016) Fourati S, Cristescu R, Loboda A, Talla A, Filali A, Railkar R, Schaeffer AK, Favre D, Gagnon D, Peretz Y, Wang IM, Beals CR, Casimiro DR, Carayannopoulos LN, S?kaly RP Nat Commun. 2016 Jan 8;7:10369

A Randomized Trial Evaluating Various Administration Routes of Natalizumab in Multiple Sclerosis (2016) Plavina T, Fox EJ, Lucas N, Muralidharan KK, Mikol D J Clin Pharmacol

Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study (2016) Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AH, Bartlett A, Kissel JT Ann Clin Transl Neurol

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Predicting Progression from Mild Cognitive Impairment to Alzheimers Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification (2016) Korolev IO, Symonds LL, Bozoki AC; Alzheimers Disease Neuroimaging Initiative PLoS One

Dynamic Macrophage Polarization-Specific miRNA Patterns Reveal Increased Soluble VEGF Receptor 1 by miR-125a-5p Inhibition. (2016) Melton DW, Lei XF, Gelfond JAL, Shireman PK Physiological Genomics

Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma (2016) Bateman ED, Goehring UM, Richard F, Watz H Journal of Allergy and Clinical Immunology

Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity (2016) Dietsch GN, Lu H, Yang Y, Morishima C, Chow LQ, Disis ML, Hershberg RM PLoS ONE

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1. Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia (2016) Jondle CN, Sharma A, Simonson TJ, Larson B, Mishra BB, Sharma J Journal of Immunology

Thrombopoietin is associated with ds intercept, and only in Non-Hispanic Whites (2016) Royall DR, Palmer RF Alzheimers & Dementia: Diagnosis, Assessment & Disease Monitoring

The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5/6 nephrectomy (2016) Tsuprykov O, Ando R, Reichetzeder C, von Websky K, Antonenko V, Sharkovska Y, Chaykovska L, Rahnenf?hrer J, Hasan AA, Tammen H, Alter M, Klein T, Ueda S, Yamagishi S, Okuda S, Hocher B Kidney International

Immune Monitoring Technology Primer: Immunoprofiling of Antigen-Stimulated Blood (2016) Brunet LR, LaBrie S, Hagemann T Journal for Immunotherapy of Cancer

System-Based Proteomic and Metabonomic Analysis of the Df(16)a+/- Mouse Identifies Potential Mir-185 Targets and Molecular Pathway Alterations (2016) Wesseling H, Xu B, Want EJ, Holmes E, Guest PC, Karayiorgou M, Gogos JA, Bahn S Molecular Psychiatry

A Sputum Proteomic Signature That Associates with Increased Il-1? Levels and Bacterial Exacerbations of COPD (2016) Damera G, Pham T-H, Zhang J, Ward CK, Newbold P, Ranade K, Sethi S Lung

Evaluation of Novel Biomarkers of Nephrotoxicity in Cynomolgus Monkeys Treated with Gentamicin (2016) Gautier J-C, Zhou X, Yang Y, Gury T, Qu Z, Palazzi X, L?onard J-F, Slaoui M, Veeranagouda Y, Guizon I, Boitier E, Filali-Ansary A, van den Berg BHJ, Poetz O, Joos T, Zhang T, Wang J, Detilleux P, Li B Toxicology and Applied Pharmacology

Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial (2016) Lerman I, Hauger R, Sorkin L, Proudfoot J, Davis B, Huang A, Lam K, Simon B, Baker DG Neuromodulation: Technology at the Neural Interface

Plasma Egf and Cognitive Decline in Parkinsons Disease and Alzheimers Disease (2016) Lim NS, Swanson CR, Cherng H-R, Unger TL, Xie SX, Weintraub D, Marek K, Stern MB, Siderowf A, Pars Investigators, Alzheimers Disease Neuroimaging Initiative, Trojanowski JQ, Chen-Plotkin AS Annals of Clinical and Translational Neurology

Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on Bmd among Young Childhood Cancer Survivors: A Randomized Clinical Trial (2016) Mogil RJ, Kaste SC, Ferry Jr RJ, Hudson MM, Mulrooney DA, Howell CR, Partin RE, Srivastava DK, Robison LL, Ness KK JAMA Oncology

A Novel Approach for Emerging and Antibiotic Resistant Infections: Innate Defense Regulators as an Agnostic Therapy (2016) North JR, Takenaka S, Rozek A, Kielczewska A, Opal S, Morici LA, Finlay BB, Schaber CJ, Straube R, Donini O Journal of Biotechnology

Apolipoprotein a-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis (2016) Walsh KB, Hart K, Roll S, Sperling M, Unruh D, Davidson WS, Lindsell CJ, Adeoye O Journal of Stroke and Cerebrovascular Diseases

High false-positive rate of a putative biomarker test to aid in the diagnosis of schizophrenia (2016) Wehler CA, Preskorn, SH Journal of Clinical Psychiatry

A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of treatment with sirukumab (CNTO 136) in patients with active lupus nephritis (2016) Rovin B, van Vollenhoven R, Aranow C, Wagner C, Gordon R, Zhuang Y, Belkowski S, Hsu B Arthritis & Rheumatology

Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time (2016) Schild M, Eichner G, Beiter T, Zuegel M, Niess AM, Steinacker JM, Mooren FC Mediators of Inflammation

Type I Ifns Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-Versus-Host Disease (2016) Delaney TA, Morehouse C, Brohawn PZ, Groves C, Colonna M, Yao, Y, Sanjuan M, Coyle AJ The Journal of Immunology

Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria*American Journal of Nephrology (2016) Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB American Journal of Nephrology

Altered Cerebrospinal Fluid Proteins in Smith?Lemli? (2016) Cologna SM, Shieh C, Toth CL, Cougnoux A, Burkert KR, Bianconi SE, Wassif CA, Porter FD American Journal of Medical Genetics Part A

Predictors of Asthma Following Severe Respiratory Syncytial Virus (Rsv) Bronchiolitis in Early Childhood (2016) Lu S, Hartert TV, Everard ML, Giezek H, Nelsen L, Mehta A, Patel H, Knorr B, Reiss TF Pediatric Pulmonology

Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2-O-Methoxyethyl Modified Antisense Oligonucleotide (2016) Shen L, Engelhardt JA, Hung G, Yee J, Kikkawa R, Matson J, Tayefeh B, Machemer T, Giclas PC, Henry SP Nucleic Acid Therapeutics

Inflammatory Profile in Lrrk2-Associated Prodromal and Clinical Pd (2016) Brockmann K, Apel A, Schulte C, Schneiderhan-Marra N, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol J-C, Cormier F, Knorpp T, Joos TO, Gasser T, Sch?le B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Marras C, Berg D, Maetzler W Journal of Neuroinflammation

Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma (2016) Choueiri TK, Fishman M, Escudier B, McDermott DF, Drake CG, Kluger HM, Stadler WM, Perez-Gracia JL, McNeel DG, Curti BD, Harrison MR, Plimack ER, Appleman L, Fong L, Albiges L, Cohen LJ, Young TC, Chasalow SD, Ross-MacDonald P, Srivastava S, Jure-Kunkel M, Kurland JF, Simon JS, Sznol M Clinical Cancer Research

Amyloid Proteotoxicity Initiates an Inflammatory Response Blocked by Cannabinoids (2016) Currais A, Quehenberger O, Armando AM, Daugherty D, Maher P, Schubert D NPJ Aging and Mechanisms of Disease

Tenascin-C drives persistence of organ fibrosis (2016) Bhattacharyya S, Wang W, Morales-Nebreda L, Feng G, Wu M, Zhou X, Lafyatis R, Lee J, Hinchcliff M, Feghali-Bostwick C, Lakota K, Budinger GRS, Raparia K, Tamaki Z, Varga J Nature Communications

Sj?gren?s Syndrome Patients with Ectopic Germinal Centers Present with a Distinct Salivary Proteome (2016) Delaleu N, Mydel P, Brun JG, Jonsson MV, Alimonti A, Jonsson R Rheumatology

Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma (2016) Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ British Journal of Cancer

Cytokine Production Capacity in Depression and Anxiety (2016) Vogelzangs N, De Jonge P, Smit JH, Bahn S, Penninx BW Translational Psychiatry

Towards a Blood-Based Diagnostic Panel for Bipolar Disorder (2016) Haenisch F, Cooper JD, Reif A, Kittel-Schneider S, Steiner J, Leweke FM, Rothermundt M, Van Beveren NJM, Crespo-Facorro B, Niebuhr DW, Cowan DN, Weber NS, Yolken RH, Penninx BWJH, Bahn S Brain, Behavior, and Immunity

Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports

Behavioural Traits Propagate across Generations Via Segregated Iterative-Somatic and Gametic Epigenetic Mechanisms (2016) Mitchell E, Klein SL, Argyropoulos KV, Sharma A, Chan RB, Toth JG, Barboza L, Bavley C, Bortolozzi A, Chen Q, Liu B, Ingenito J, Mark W, Dudakov J, Gross S, Di Paolo G, Artigas F, Van Den Brink M, Toth M Nature Communications

Characterizing the Inflammatory Response in Esophageal Mucosal Biopsies in Children with Eosinophilic Esophagitis (2016) Sayej WN, Menoret A, Maharjan AS, Fernandez M, Wang Z, Balarezo F, Hyams JS, Sylvester FA, Vella AT Clinical & Translational Immunology

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD (2016) Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen T-H, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O?neal WK, Bowler RP, Group SR, Investigators CO PLOS Genetics

Primary Analysis Of A Phase II Open-Label Trial Of INCB039110, A Selective JAK1 Inhibitor, In Patients With Myelofibrosis (2016) Mascarenhas JO, Talpaz M, Gupta V, Foltz LM, Savona MR, Paquette R, Turner AR, Coughlin P, Winton E, Burn TC, ONeill P, Clark J, Hunter D10, Assad A, Hoffman R, Verstovsek S Haematologica

Plasma Inflammatory Factors Are Associated with Anxiety, Depression, and Cognitive Problems in Adults with and without Methamphetamine Dependence: An Exploratory Protein Array Study (2015) Huckans M, Fuller BE, Chalker ALN, Adams M, Loftis JM Frontiers in Psychiatry

Comparison of Plasma and Urine Biomarker Performance in Acute Kidney Injury (2015) Schley G, K?berle C, Manuilova E, Rutz S, Forster C, Weyand M, Formentini I, Kientsch-Engel R, Eckardt K-U, Willam C PLoS ONE

Dysregulation of Serum Gamma Interferon Levels in Vascular Chronic Q Fever Patients Provides Insights into Disease Pathogenesis (2015) Pennings JLA, Kremers MNT, Hodemaekers HM, Hagenaars JCJP, Koning OHJ, Renders NHM, Hermans MHA, De Klerk A, Notermans DW, Wever PC, Janssen R Clinical and Vaccine Immunology

Cd4+ T-Cell Profiles and Peripheral Blood Ex-Vivo Responses to T-Cell Directed Stimulation Delineate Copd Phenotypes (2015) Roberts MEPH, Brandon W.; Brohawn, Philip; Pilataxi, Fernanda; Guo, Xiang; Kuziora, Michael; Bowler, Russell P.; White, Wendy I. Chronic Obstructive Pulmonary Diseases

Bone Marrow from Blotchy Mice Is Dispensable to Regulate Blood Copper and Aortic Pathologies but Required for Inflammatory Mediator Production in Ldlr-Deficient Mice During Chronic Angiotensin Ii Infusion (2015) Harris D, Liang Y, Chen C, Li S, Patel O, Qin Z Annals of Vascular Surgery

Plasma Protein Profiling of Mild Cognitive Impairment and Alzheimers Disease across Two Independent Cohorts (2015) Muenchhoff JP, Anne; Song, Fei; Raftery, Mark; Brodaty, Henry; Duncan, Mark; Mcevoy, Mark; Attia, John; Schofield, Peter W.; Sachdev, Perminder S. Journal of Alzheimers Disease

BAFF (B Cell Activating Factor) Transcript Level in Peripheral Blood of Patients with SLE Is Associated with Same-Day Disease Activity as Well as Global Activity over the Next Year (2015) Zollars E, Bienkowska J, Czerkowicz J, Allaire N, Ranger AM, Magder L, Petri M Lupus Science

Mechanisms of Three-Dimensional Growth of Thyroid Cells During Long-Term Simulated Microgravity*Scientific Reports (2015) Kopp S, Warnke E, Wehland M, Aleshcheva G, Magnusson NE, Hemmersbach R, Corydon TJ, Bauer J, Infanger M, Grimm D Scientific Reports

A Phase I/Ii Trial of Bnc105p with Everolimus in Metastatic Renal Cell Carcinoma (2015) Pal S, Azad A, Bhatia S, Drabkin H, Costello B, Sarantopoulos J, Kanesvaran R, Lauer R, Starodub A, Hauke R, Sweeney CJ, Hahn NM, Sonpavde G, Richey S, Breen T, Kremmidiotis G, Leske A, Doolin E, Bibby DC, Simpson J, Iglesias J, Hutson T Clinical Cancer Research

The Milieu Int?rieur Study ? an Integrative Approach for Study of Human Immunological Variance (2015) Thomas S, Rouilly V, Patin E, Alanio C, Dubois A, Delval C, Marquier L-G, Fauchoux N, Sayegrih S, Vray M, Duffy D, Quintana-Murci L, Albert ML, Abel L, Alcover A, Bousso P, Bruhns P, Cumano A, Da?ron M, Delval C, Demangel C, Deriano L, Di Santo J, Dromer F, Eberl G, Enninga J, Freitas A, Gelpi O, Gomperts-Boneca I, Hercberg S, Lantz O, Leclerc C, Mouquet H, Pellegrini S, Pol S, Rogge L, Sakuntabhai A, Schwartz O, Schwikowski B, Shorte S, Soumelis V, Tangy F, Tartour E, Toubert A, Ungeheuer M-N, Quintana-Murci L, Albert ML Clinical Immunology

Time Course of Cigarette Smoke-Induced Changes of Systemic Inflammation and Muscle Structure (2015) Kr?ger K, Dischereit G, Seimetz M, Wilhelm J, Weissmann N, Mooren FC American Journal of Physiology - Lung Cellular and Molecular Physiology

Plasma Angiopoietin-2 Outperforms Other Markers of Endothelial Injury in Prognosticating Pediatric ARDS Mortality (2015) Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A American Journal of Physiology - Lung Cellular and Molecular Physiology

Enhancement of Patient Recruitment in Rheumatoid Arthritis Clinical Trials Using a Multi-Biomarker Disease Activity Score as an Inclusion Criterion (2015) Van Vollenhoven R, Bolce R, Hambardzumyan K, Saevarsdottir S, Forslind K, Petersson I, Sasso E, Hwang C, Segurado O, and Geborek P Arthritis & Rheumatol

Multibiomarker disease activity score and C-reactive protein in a cross-sectional observational study of patients with rheumatoid arthritis with and without concomitant fibromyalgia (2015) Lee YC, Hackett J, Frits M, Iannaccone C, Shadick N, Weinblatt M, Segurado O and Sasso E Rheumatology

Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment (2015) Rech J, Hueber AJ, Finzel S, Englbrecht M, Haschka J, Manger B, Kleyer A, Reiser M, Cobra JF, Figueiredo C, Tony HP, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Lorenz H-M, Nuesslein H, Alten R, Henes J, Krueger K, Schett G Ann Rheum Dis.

Relationship of multi-biomarker disease activity score and other risk factors with radiographic progression in an observational study of patients with rheumatoid arthritis (2015) Li W, Sasso E, van der Helm-van Mil A and Huizinga T Rheumatology

Interpreting the multi-biomarker disease activity score in the context of tocilizumab treatment for patients with rheumatoid arthritis (2015) Reiss WG, Devenport JN, Low JM, Wu G, Sasso E Rheumatol Int

Outcomes and costs of incorporating a multibiomarker disease activity test in the management of patients with rheumatoid arthritis (2015) Michaud K, Strand V, Shadick NA, Degtiar I, Ford K, Michalopoulos SN and Hornberger J Rheumatology

The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results From a Phase 3, Randomized, Placebo-Controlled Trial (PALACE 1). (2015) Schafer P, Chen P, Fang L, Wang A, Chopra R. J Immunol Res 2015 Jan 10 [Epub ahead of print]

Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods. (2015) Morrow JD, Qiu W, Chhabra D, Rennard SI, Belloni P, Belousov A, Pillai SG, Hersh CP. BMC Med Genomics. 2015 Jan 13;8(1):1. [Epub ahead of print]

Acute and chronic plasma metabolomic and liver transcriptomic stress effects in a mouse model with features of post-traumatic stress disorder. (2015) Gautam A, DArpa P, Donohue DE, Muhie S, Chakraborty N, Luke BT, Grapov D, Carroll EE, Meyerhoff JL, Hammamieh R, Jett M. PLoS One. 2015 Jan 28;10(1):e0117092. doi: 10.1371/journal.pone.0117092. eCollection 2015.

Evaluation of thymosin alpha 1 (Ta1) in nonclinical models of the immune-suppressing indications melanoma and sepsis. (2015) King RS, Tuthill C. Expert Opin Biol Ther. 2015 Feb 2:1-9. [Epub ahead of print]

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The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses. (2015) Christiansson L, Soderlund S, Mangsbo SM, Hjorth-Hansen H, H?glund M, Markevarn B, Richter J, Stenke L, Mustjoki S, Loskog A, Olsson-Stromberg U. Mol Cancer Ther. 2015 Mar 11. pii: molcanther.0849.2014. [Epub ahead of print]

Study of cardiovascular disease biomarkers among tobacco consumers, part 2: biomarkers of biological effect. (2015) Nordskog BK, Brown BG, Marano KM, Campell LR, Jones BA, Borgerding MF. Inhal Toxicol. 2015 Mar 19:1-10. [Epub ahead of print]

Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory. (2015) Kim A, Fagan AM, Goate AM, Benzinger TL, Morris JC, Head D; Alzheimer?s Disease Neuroimaging Initiative. Cogn Affect Behav Neurosci. 2015 Mar 18. [Epub ahead of print]

Detection of Rheumatoid Arthritis-Interstitial Lung Disease is Enhanced by Serum Biomarkers. (2015) Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC, Golzarri MF, Traslosheros A, Chu SG, Frits ML, Iannaccone CK, Koontz D, Fuhrman C, Weinblatt ME, El-Chemaly SY, Washko GR, Hunninghake GM, Choi AM, Dellaripa PF, Oddis CV, Shadick NA, Ascherman DP, Rosas IO. Am J Respir Crit Care Med. 2015 Mar 30. [Epub ahead of print]

The long-acting ?2-agonist olodaterol attenuates pulmonary inflammation. (2015) Wex E, Kollak I, Duechs MJ, Naline E, Wollin L, Devillier P. Br J Pharmacol. 2015 Mar 30. doi: 10.1111/bph.13143. [Epub ahead of print]

Novel first-dose adverse drug reactions during a phase I trial of olipudase alfa (recombinant human acid sphingomyelinase) in adults with Niemann-Pick disease type B (acid sphingomyelinase deficiency). (2015) McGovern MM, Wasserstein MP, Kirmse B, Duvall WL, Schiano T, Thurberg BL, Richards S, Cox GF. Genet Med. 2015 Apr 2. doi: 10.1038/gim.2015.24. [Epub ahead of print]

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product. (2015) Phillips B, Veljkovic E, Peck MJ, Buettner A, Elamin A, Guedj E, Vuillaume G, Ivanov NV, Martin F, Bou?b S, Schlage WK, Schneider T, Titz B, Talikka M, Vanscheeuwijck P, Hoeng J, Peitsch MC. Food Chem Toxicol. 2015 Apr 2. pii: S0278-6915(15)00088-5. doi: 10.1016/j.fct.2015.03.009. [Epub ahead of print]

Temporal phenotypic features distinguish polarized macrophages in vitro. (2015) Melton DW, McManus LM, Gelfond JA, Shireman PK. Autoimmunity. 2015 Mar 31:1-16. [Epub ahead of print]

Serum IGF-BP2 Strongly Moderates Age?s Effect on Cognition: A MIMIC Analysis. (2015) Royall DR, Bishnoi RJ, Palmer RF Neurobiol. Aging. 14 April 2015. [Epub ahead of print]

Mechanism-based combination treatment dramatically increases therapeutic efficacy in murine globoid cell leukodystrophy. (2015) Hawkins-Salsbury JA, Shea L, Jiang X, Hunter DA, Guzman AM, Reddy AS, Qin EY, Li Y, Gray SJ, Ory DS, Sands MS. J Neurosci. 2015 Apr 22;35(16):6495-505. doi: 10.1523/JNEUROSCI.4199-14.2015.

Alarmin function of galectin-9 in murine respiratory tularemia. (2015) Steichen AL, Simonson TJ, Salmon SL, Metzger DW, Mishra BB, Sharma J. PLoS One. 2015 Apr 21;10(4):e0123573. doi: 10.1371/journal.pone.0123573. eCollection 2015.

Plasma BDNF levels associate with Pittsburgh Compound B binding in the brain. (2015) Hwang KS, Lazaris AS, Eastman JA, Teng E, Thompson PM, Gylys KH, Cole GM, Apostolova LG, for the Alzheimers Dement (Amst) 2015 Apr 22. [Epub ahead of print]

Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study. (2015) Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, de Geus EJ, Penninx BW, Dekker J. Ann Rheum Dis. 2015 Apr 22. pii: annrheumdis-2014-206741. doi: 10.1136/annrheumdis-2014-206741. [Epub ahead of print]

CHOP Links Endoplasmic Reticulum Stress to NF-kB Activation in the Pathogenesis of Nonalcoholic Steatohepatitis. (2015) Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC. Mol Biol Cell. 2015 Apr 22. pii: mbc.E15-01-0036. [Epub ahead of print]

Discovery of serum biomarkers predicting development of a subsequent depressive episode in social anxiety disorder. (2015) Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BW, Bahn S. Brain Behav Immun. 2015 Apr 28. pii: S0889-1591(15)00118-X. doi: 10.1016/j.bbi.2015.04.011. [Epub ahead of print]

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model. (2015) Atkinson SM, Nansen A, Usher PA, Sondergaard BC, Mackay CR, Friedrichsen B, Chang CC, Tang R, Skov S, Haase C, Hornum L. Autoimmunity. 2015 Apr 27:1-11. [Epub ahead of print]

Total testosterone and neuropsychiatric symptoms in elderly men with Alzheimer?s disease. (2015) Hall JR, Wiechmann AR, Cunningham RL, Johnson LA, Edwards M, Barber RC, Singh M, Winter S, O?Bryant SE, and for the Texas Alzheimer?s Research and Care Consortium. Alzheimers Res Ther. 2015; 7(1): 24. Published online 2015 May 1. doi: 10.1186/s13195-015-0107-4

Effect of cerium oxide nanoparticles on sepsis induced mortality and NF-?B signaling in cultured macrophages. (2015) Selvaraj V, Manne ND, Arvapalli R, Rice KM, Nandyala G, Fankenhanel E, Blough ER. Nanomedicine (Lond). 2015 Apr;10(8):1275-88. doi: 10.2217/nnm.14.205.

Blood Protein Markers of Neocortical Amyloid-? Burden: A Candidate Study Using SOMAscan Technology. (2015) Voyle N, Baker D2, Burnham SC, Covin A, Zhang Z, Sangurdekar DP, Tan Hehir CA, Bazenet C, Lovestone S, Kiddle S, Dobson RJ. J Alzheimers Dis. 2015 Apr 16. [Epub ahead of print]

Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles. (2015) Selvaraj V, Nepal N1, Rogers S, Manne ND, Arvapalli R, Rice KM, Asano S, Fankhanel E, Ma JJ, Shokuhfar T, Maheshwari M, Blough ER. Biomaterials. 2015 May 8;59:160-171. doi: 10.1016/j.biomaterials.2015.04.025. [Epub ahead of print]

Ferritin levels in the cerebrospinal fluid predict Alzheimers disease outcomes and are regulated by APOE. (2015) Ayton S, Faux NG, Bush AI; Alzheimers Disease Neuroimaging Initiative. Nat Commun. 2015 May 19;6:6760. doi: 10.1038/ncomms7760.

Hippocampal proteomic and metabonomic abnormalities in neurotransmission, oxidative stress and apoptotic pathways in a chronic phencyclidine rat model. (2015) Wesseling H, Want EJ, Guest PC, Rahmoune H, Holmes E, Bahn S. J Proteome Res. 2015 Jun 4. [Epub ahead of print]

Immune cell profiling to guide therapeutic decisions in rheumatic diseases. (2015) Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S. Nat Rev Rheumatol. 2015 Jun 2. doi: 10.1038/nrrheum.2015.71. [Epub ahead of print]

Immunomodulatory Effects of Probiotic Supplementation in Schizophrenia Patients: A Randomized, Placebo-Controlled Trial. (2015) Tomasik J, Yolken RH, Bahn S, Dickerson FB. Biomark Insights. 2015 Jun 1;10:47-54. doi: 10.4137/BMI.S22007. eCollection 2015.

Multiplex immunoassay analysis of plasma shows differences in biomarkers related to manic or mixed mood states in bipolar disorder patients. (2015) Haenisch F, Alsaif M, Guest PC, Rahmoune H, Yolken R, Dickerson F, Bahn S. Journal of Affective Disorders. 2015 Jun 24. doi:10.1016/j.jad.2015.05.065. [Epub ahead of print]

Suppression of T Cell Activation and Collagen Accumulation by an Anti-Type I Interferon Receptor Monoclonal Antibody in Adult Patients with Systemic Sclerosis. (2015) Guo X, Higgs BW, Bay-Jensen AC, Karsdal MA, Yao Y, Roskos LK, White WI. J Invest Dermatol. 2015 May 20. doi: 10.1038/jid.2015.188. [Epub ahead of print]

Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of TNF-a receptor 1 (2015) Cordy JC, Morley PJ, Wright TJ, Birchler MA, Lewis AP, Emmins R, Chen YZ, Powley WM, Bareille PJ, Wilson R, Tonkyn J, Bayliffe AI, Lazaar AL. Clin Exp Immunol.

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans (2015) Saykin A, Shen L, Xiohui Y, Kim S, Kwangsik N, Risacher SL, Ramanan VK, Foroud T, Faber KM, Sarwar N, Minsie L, Xiaolan H, Soares HD, Potkin S, Thompson PM, Kauwe JSK, Kaddurah-Daouk R, Green RC, Toga AW, Weiner MW Alzheimers & Dementia

Perspective: The Alzheimers Disease Neuroimaging Initiative and the role and contributions of the Private Partner Scientific Board (PPSB) (2015) Liu E, Luthman J, Cedarbaum JM, Scmidt ME, Cole PE, Hendrix J, Carillo MC, Jones-Davis D, Tarver E, Novak G, De Santi S, Soares HD, Potter QZ, Siemers E, Schwarz AJ Alzheimers & Dementia

Biomarkers of rapid chronic kidney disease progression in type 2 diabetes (2015) Looker HC, Colombo M, Hess S, Brosnan MJ, Farran B, Dalton RN, Wong MC, Turner C, Palmer CNA, Nogceke E, Groop L, Salomaa V, Dunger DB, Agakov F, McKeigue PM, Colhoun HM Kidney International

Identifying amyloid pathology?related cerebrospinal fluid biomarkers for Alzheimers disease in a multicohort study (2015) Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, Soares HD, Kling MA, Mailman M, Arnold SE, Narayan VA, Lee VMY, Shaw LM, Baker D, Wittenberg GM, Trojanowski JQ, Wang LS Alzheimers & Dementia

Angiogenesis Dysregulation in Term Asphyxiated Newborns Treated with Hypothermia (2015) Shaikh H, Boudes E, Khoja Z, Shevell M, Wintermark P PLOS One

Late Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337) (2015) Dietsch GN, Randall TD, Gottardo R, Northfelt DW, Ramanathan RK, Cohen PA, Manjarrez KL, Newkirk M, Bryan JK, Hershberg RM Clinical Cancer Research

A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis (2015) Pardanani A, Tefferi A, Jamieson C, Gabrail NY, Lebedinsky C, Gao G, Liu F, Xu C, Cao H and Talpaz M Blood Cancer Journal

THU0223 Serum Biomarkers Associated with Changes in Asdas and MRI Following Treatment of Ankylosing Spondylitis with Golimumab (2015) Inman RD, Baraliakos X, Hermann KG, Braun J, Deodhar A, van der Heijde DF, Xu S, Hsu B Ann Rheum Dis

Identification of plasma biomarker concentration changes resulting from the administration of the Vascular Disrupting Agent BNC105 across 3 clinical trials in mesothelioma, ovarian and renal cancer (2015) Kremmidiotis G, Leske A, Simpson J, Doolin E, Iglesias J AACR 2015

Biomarker results from a clinical trial of nivolumab in patients (pts) with metastatic renal cell carcinoma (mRCC) (CA209-009): Gene expression, serum profiling for immune markers, and multiplex tissue immunohistochemistry (IHC) (2015) Choueiri TK, Fishman MN, Escudier B, Stadler WM, Chasalow S, Ross-Macdonald P, Jure-Kunkel M, Sznol M, and Simon JS Cancer Res

Novel data-mining approach identifies biomarkers for diagnosis of Kawasaki disease (2015) Tremoulet AH, Dutkowski J, Sato Y, Kanegaye JT, Ling XB, Burns JC Pediatr Res.

Common Effects on Cancer Cells Exerted by a Random Positioning Machine and a 2D Clinostat (2015) Svejgaard B, Wehland M, Ma X, Kopp S, Sahana J, Warnke E, Aleshcheva G, Hemmersbach R, Hauslage J, Grosse J, Bauer J, Corydon TJ, Islam T, Infanger M, Grimm D PLoS One

Central and peripheral changes underlying susceptibility and resistance to social defeat stress ? a proteomic profiling study (2015) Stelzhammer V, Ozcan S, Gottschalk MG, Steeb H, Hodes GE, Guest PC, Rahmoune H, Wong EHF, Russo SJ, Bahn S Diagnostics in Neuropsychiatry

A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimers Disease. (2015) Khan W, Aguilar C, Kiddle SJ, Doyle O, Thambisetty M, Muehlboeck S, Sattlecker M, Newhouse S, Lovestone S, Dobson R, Giampietro V, Westman E, Simmons A PLoS One

Multianalyte markers of schizophrenia and bipolar disorder: A preliminary study. (2015) Dickerson F, Schroeder J, Stallings C, Origoni A, Bahn S, Yolken R Schizophr Res.

PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation. (2015) Adage T, Del Bene F, Fiorentini F, Doornbos RP, Zankl C, Bartley MR, Kungl AJ Cytokine

Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague?Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology (2015) Phillips B, Esposito M, Verbeeck J, Bou? S, Iskandar A, Vuillaume G, Leroy P, Krishnan S, Kogel U, Utan A, Schlage WK, Bera M, Veljkovic E, Hoeng J, Peitsch MC, Vanscheeuwijck P Inhal Toxicol.

Therapeutic Potential of Cerium Oxide Nanoparticles for the Treatment of Peritonitis Induced by Polymicrobial Insult in Sprague-Dawley Rats. (2015) Manne ND, Arvapalli R, Nepal N, Thulluri S, Selvaraj V, Shokuhfar T, He K, Rice KM, Asano S, Maheshwari M, Blough ER Crit Care Med.

A Phase 1 Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma (2015) Amaravadi RK, Schilder RJ, Martin LP, Levin M, Graham MA, Weng DE, Adjei AA Mol Cancer Ther.

Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice (2015) Mardare C, Kr?ger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC J Diabetes Res

Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia (2015) Tomasik J, Schultz TL, Kluge W, Yolken RH, Bahn S, Carruthers VB Schizophr Bull

Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining (2015) Yoshimura K, Okanoue T, Ebise H, Iwasaki T, Mizuno M, Shima T, Ichihara J, Yamazaki K Hepatology.

Lipoprotein-associated phospholipase A2, homocysteine, and Alzheimer?s disease (2015) Doody RS, Demirovic J, Ballantyne CM, Chan W, Barber R, Powell S, Pavlik V Alzheimers Dement (Amst)

Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immune monitoring data (2015) Parkitny L, Middleton S, Baker K, Younger J BMC Immunology

Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use (2015) Srivastava AK, Jaganathan S, Stephen L, Hollingshead MG, Govindharajulu JP, Layhee A, Damour E, Donohue J, Esposito D, Mapes JP, Kinders R, Takebe N, Tomaszewski JE, Kummar S, Doroshow JH, Parchment RE Clinical Cancer Research

A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression (2015) Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ J Immunol.

Cerium oxide nanoparticles attenuate acute kidney injury induced by intra-abdominal infection in Sprague?Dawley rats (2015) Manne ND, Arvapalli R, Nepal N, Shokuhfar T, Rice KM, Asano S, Blough ER J Nanobiotechnology

Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients (2015) Tomasik J, Schwarz E, Lago SG, Rothermundt M, Leweke FM, van Beveren NJ, Guest PC, Rahmoune H, Steiner J, Bahn S. Brain Behav Immun.

MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis (2015) Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. J Clin Invest

Markers of inflammation are associated with clinical outcomes in patients with metastatic renal cell carcinoma treated with nivolumab (2015) Sznol M, Fishman M, Escudier B, McDermott DF, Kluger H, Stadler WM, Perez-Gracia J, McNeel DG, Curti BD, Harrison MR, Plimack ER, Appleman L, Fong L, Drake CG, Young TC, Chasalow SD, Ross-MacDonald P, Simon JS, Walker D, Choueiri TK J Immunother Cancer

Identification of circulatory biomarkers from clinical trial samples (2015) Brunet LR, Bodman-Smith K, Bodman-Smith M, Kassam Z, Dalgleish A, LaBrie S and Hagemann T J Immunother Cancer

Plasma Biomarkers for Neuronal Ceroid Lipofuscinosis. (2015) Hersrud SL, Geraets RD, Weber KL, Chan CH, Pearce DA FEBS J.

Serum biomarkers predictive of depressive episodes in panic disorder (2015) Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BWJH, Bahn S Journal of Psychiatric Research

Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders (2015) Ramsey JM, Guest PC, Broek JA, Glennon JC, Rommelse N, Franke B, Rahmoune H, Buitelaar JK, Bahn S. Mol Autism

Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders. (2015) Wesseling H, Guest PC, Lee CM, Wong EH, Rahmoune H, Bahn S Mol Autism.

Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion. (2015) Poussin C, Laurent A, Peitsch MC, Hoeng J, De Leon H Toxicol Sci.

MEDI-551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Sle1-Human CD19 Transgenic Mice. (2015) Gallagher S, Yusuf I, McCaughtry TM, Turman S, Sun H, Kolbeck R, Herbst R, Wang Y Arthritis Rheumatol.

Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer (2015) Pommier AJC, Farren M, Patel B, Wappett M, Michopoulos F, Smith NR, Kendrew J, Frith J, Huby R, Eberlein C, Campbell H, Womack C, Smith PD, Robertson J, Morgan S, Critchlow SE, Barry ST Cell Metabolism

Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells (2015) Poussin C, Laurent A, Peitsch MC, Hoeng J, and De Leon H Toxicology

Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders (2015) Frye MA, Nassan M, Jenkins GD, Kung S, Veldic M, Palmer BA, Feeder SE, Tye SJ, Choi DS and Biernacka HM Translational Psychiatry

Prognostic and predictive biomarkers of AAA growth rate. (2015) Deeg MA, Meijer CA, Chan LS, Shen L, Lindeman JH. Curr Med Res Opin

Self-reactive IgE exacerbates interferon responses associated with autoimmunity (2015) Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA Nat Immunol.

Comparing biological markers of Alzheimers disease across blood fraction and platforms: Comparing apples to oranges (2015) OBryant SE, Listac S, Rissman RA, Edwards M, Zhang F, Hall J, Zetterberg H, Lovestone S, Gupta V, Graff-Radford N, Martins R, Jeromin A, Waring S, Oh E, King M, Baker L, Hampel H Alzheimers Dement (2015) 1-8

Characterization of Renal Biomarkers for Use in Clinical Trials: Effect of Preanalytical Processing and Qualification Using Samples from Subjects with Diabetes (2015) Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N Drug Design, Development and Therapy

Low Plasma Apoe Levels Are Associated with Smaller Hippocampal Size in the Alzheimers Disease Neuroimaging Initiative Cohort (2015) Teng E, Chow N, Hwang KS, Thompson PM, Gylys KH, Cole GM, Jack Jr CR, Shaw LM, Trojanowski JQ, Soares HD, Weiner MW, Apostolova LG Dementia and Geriatric Cognitive Disorders

Identifying Novel Biomarkers for Cardiovascular Events or Death in People with Dysglycemia (2015) Gerstein HC, Par? G, Mcqueen MJ, Haenel H, Lee SF, Pogue J, Maggioni AP, Yusuf S, Hess S Circulation

An Adaptive Genetic Algorithm for Selection of Blood-Based Biomarkers for Prediction of Alzheimers Disease Progression (2015) Vandewater L, Brusic V, Wilson W, Macaulay L, Zhang P BMC Bioinformatics

Serum Proteomic Profiling of Major Depressive Disorder (2015) Bot M, Chan MK, Jansen R, Lamers F, Vogelzangs N, Steiner J, Leweke FM, Rothermundt M, Cooper J, Bahn S, Penninx BWJH Translational Psychiatry