Pigment Epithelium Derived Factor

Pigment epithelium-derived factor (PEDF) was discovered as a protein secreted by the retinal pigmented epithelium, with the ability to promote the differentiation of primitive retinal cells into cells of a neuronal phenotype. It has since been found to be multifunctional, with neurotrophic and anti-angiogenic properties. PEDF is one of the most abundant adipokines and its secretion is inversely regulated by insulin and hypoxia. Serum PEDF is increased in patients with type 2 diabetes.

Swiss-Prot Accession Number: P36955