Neurofilament Light Chain Simoa

Neurofilament Light Chain (NF-L) is a soluble cytoskeletal intermediate filament protein expressed in myelinated axons. These 68 kDa protein associates with Neurofilament medium (NfM) and Neurofilament heavy (NfH) to form neurofilaments. Damage or degeneration of neurons releases neurofilaments proportionally to severity of disease. Increased concentrations of NF-L can be measured in the cerebrospinal fluid (CSF) and blood. NF-L correlates to the severity of neurological disorders, including traumatic brain injuries, Parkinson?s disease, Multiple Sclerosis, ALS, Dementia, Motor Neuron Disease, Creutzfeldt-Jakob disease, Huntington?s disease, and normal pressure hydrocephalus. In HIV-associated Dementia (HAD) concentrations of NF-L in the CSF are significantly elevated.

Swiss-Prot Accession Number: P07196