Platelet basic protein (PBP, CXCL7), which is found in the alpha-granules of human platelets is proteolytically cleaved to form Neutrophil activating peptide 2 (NAP-2), connective tissue activating protein III (CTAP-III) and beta-thrombogulin (beta-TG). NAP-2 binds CXCR2 and chemoattracts and activates neutrophils. Serum NAP-2 is increased in lung and hepatic cancers.
Swiss-Prot Accession Number: P02775
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