Macrophage Inflammatory Protein-1 alpha
Macrophage Inflammatory Protein-1 alpha (MIP-1 alpha, CCL3, MIP-1a) is one of two MIP proteins that are the major factors produced by macrophages following their stimulation with bacterial endotoxins. Both proteins are involved in the cell activation of human granulocytes (neutrophils, eosinophils, and basophils) and appear to be involved in acute neutrophilic inflammation. Both forms of MIP-1 stimulate the production of reactive oxygen species in neutrophils and the release of lysosomal enzymes. They also induce the synthesis of other pro-inflammatory cytokines such as IL-1, IL-6, and TNF in fibroblasts and macrophages.
Swiss-Prot Accession Number: P10147
