Macrophage-Derived Chemokine
Macrophage-Derived Chemokine (MDC; CCL22) is expressed highly in macrophages and in monocyte-derived dendritic cells. High expression is detected in normal thymus and lower expression in lung and spleen. MDC is expressed by a subset of macrophages within regions of advanced atherosclerotic plaques that contain plaque micro-vessels. MDC is a potent chemoattractant for neutrophilic granulocytes, enhancing their bactericidal activity and stimulating the release of lysozyme.
Swiss-Prot Accession Number: O00626
