Monocyte Chemotactic Protein 2

Monocyte Chemotactic Protein 2 (MCP-2; CCL8), is a chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. MCP-2 may play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Highest expression of MCP-2 is found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate. It is induced by IFNG/IFN-gamma, mitogens, and IL-1.

Swiss-Prot Accession Number: P80075