Leptin
Leptin
Leptin is a protein hormone produced predominantly in the adipocytes and plays an important role in the regulation of body weight through the hypothalamic centers for hunger, body temperature, and energy expenditure. Increased leptin levels are seen in obese individuals and leptin levels have been shown to change under certain endocrine conditions. Its role in metabolism, insulin sensitivity, as a therapeutic modality for weight loss, and involvement in endocrine function is under investigation.
Swiss-Prot Accession Number: P41159
Bibliography
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medical_services Therapy IndicationsA Phase 2, Randomized, Double-blind, Multicenter Study Comparing Siltuximab Plus Best Supportive Care With Placebo Plus Best Supportive Care in Anemic Patients With International Prognostic Scoring System Low- or Intermediate-1?Risk Myelodysplastic Syndrome (2014) Garcia-Manero G, Gartenberg G, Steensma DP, Schipperus MR, Breems DA, de Paz R, Valc?rcel D, Kranenburg B, Reddy M, Komrokji RS Am J Hematol. 2014 May 31
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medical_services Therapy IndicationsLY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys (2013) Adams AC, Halstead CA, Hansen BC, Irizarry AR, Martin JA, Meyers SR, Reynolds VL, Smith HW, Wroblewski VJ, Kharitonenkov A PLoS ONE 8(6): e65763
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