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Interferon-inducible T-cell alpha chemoattractant

Interferon-inducible T-cell alpha chemoattractant

Interferon-inducible T-cell alpha chemoattractant (ITAC, CXCL11) is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus and spleen. Gene expression of ITAC/CXCL11 is strongly induced by IFN-gamma and IFN- beta, and weakly induced by IFN-alpha. ITAC/CXCL11 is chemotactic for activated T cells. It may play role in CNS diseases and skin immune responses.

Swiss-Prot Accession Number: O14625


Bibliography

Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study (2025) Monique Hinchcliff, MD, Prof Dinesh Khanna, MD, Enrico De Lorenzis, MD, Stefano Di Donato, MD, Antonio Carriero, MD, Rebecca L Ross, PhD, Suiyuan Huang, MPH, Kathleen A Aren, MPH, Elana J Bernstein, MD, Mary Carns, MS, Flavia V Castelino, MD, Robyn T Domsic, MD, Tracy M Frech, MD, Jessica K Gordon, MD, Faye N Hant, MD, Prof Ami A Shah, MD, Victoria K Shanmugam, MBBS, Prof Virginia D Steen, MD, Prof Shervin Assassi, MD, Prof Francesco Del Galdo, PhD The Lancet Rheumatology

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A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression (2015) Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ J Immunol.

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Interleukin 17F Level and Interferon Beta Response in Patients With Multiple Sclerosis (2013) Hartung HP, Steinman L, Goodin DS, Comi G, Cook S, Filippi M, OConnor P, Jeffery DR, Kappos L, Axtell R, Knappertz V, Bogumil T, Schwenke S, Croze E, Sandbrink R, Pohl C JAMA Neurol. 2013 Aug 1;70(8):1017-21

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