Interleukin-8 (IL-8, CXCL8, GCP-1, or NAP-1) is a proinflammatory chemokine produced by many cell types including those involved in innate immunity, especially monocytes and epithelial cells.? IL-8 induces neutrophil chemotaxis and phagocytosis in response to infections. An ELR motif, which is responsible for the protein?s angiogenic properties is at the N-terminus of the protein. IL-8 can homodimerize or can form a heterodimer with CXCL4/PF4. The monomer and homodimer forms of IL-8 bind to and induce activation of chemokine receptors CXCR1 and CXCR2.
IL-8 induction of CXCR1 triggers neutrophil antimicrobial activation and migration to sites of infection or inflammation and has been associated with obesity. IL-8 is a proinflammatory mediator in gingivitis and psoriasis and may be a factor in colorectal cancer. The angiogenic property of IL-8 has been implicated in driving angiogenesis in several cancers including gastric cancers and head and neck cancers. IL-8 is a regulator of the central nervous system (CNS) function and development and plays a key role in gliomas. High levels of maternal IL-8 have been associated with increased risk of schizophrenia and it has been implicated in cystic fibrosis.
Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers?In cognitively unimpaired older adults (2023)Elettra Capogna, Leiv Otto Watne, ?ystein S?rensen, Carlijn Jamila Guichelaar, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Pi?eiro Brain Behavior Immunology
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease (2021)Pierson SK, Shenoy S, Oromendia AB, Gorzewski AM, Pai RA, Nabel CS, Ruth JR, parente SAT, Arenas DJ, Guilfoyle M, Reddy MP, Weinblatt M, Shadick N, Bower M, Pria AD, Masaki Y, Katz L, Mezey J, Beineke P, Lee D, Tendler C, Kambayashi T, Fossa A, van Rhee F, Fajgenbaum DC Blood Advances
Biomarker signature in cancer patients with and without venous thromboembolism events: a substudy of CASSINI (2021)Khorana A, Barnard J, Wun T, Vijapurkar U, Damaraju CV, Moore K, Wildgoose P, McCrae K Blood Advances
Elevated serum interlukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors (2020)Schalper KA, Carleton M, Zhou M, Chen T, Feng Y, Huang SP, Walsh AM, Baxi V, Pandya D, Baradet T, Locke D, Wu Q, Reilly TP, Phillips P, Nagineni V, Gianino N, Gu J, Zhao H, Perez-Gracia JL, Snmamed MF, Melero I Nature Medicine
Cellular toxicity of silicon carbide nanomaterials as a function of morphology (2018)Chen F, Li G, Zhao ER, Li J, Hableel G, Lemaster JE, Bai Y, Sen GL, Jokerst JV Biomaterials
Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial (2016)Lerman I, Hauger R, Sorkin L, Proudfoot J, Davis B, Huang A, Lam K, Simon B, Baker DG Neuromodulation: Technology at the Neural Interface
PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation. (2015)Adage T, Del Bene F, Fiorentini F, Doornbos RP, Zankl C, Bartley MR, Kungl AJ Cytokine
Interleukin-8 Mediates Resistance to Antiangiogenic Agent Sunitinib in Renal Cell Carcinoma. (2010)Huang D, Ding Y, Zhou M, Rini BI, Petillo D, Qian CN, Kahnoski R, Futreal PA, Furge KA, Teh BT Cancer Res 70: 1063-1071.
Identifying early markers of Alzheimers disease using quantitative multiplex proteomic immunoassay panels (2009)Soares HD, Chen Y, Sabbagh M, Roher A, Schrijvers E, Breteler M Ann N Y Acad Sci. 1180 :56-67.
