Interleukin-7

Interleukin-7 (IL-7) stimulates the proliferation of pre-B and pro-B-cells without affecting their differentiation. It also selectively supports the maturation of megakaryocytes. In human peripheral monocytes, IL-7 induces the synthesis of some inflammatory mediators such as IL-1 and IL-6. It also enhances the expression and secretion of IL-3 and GM-CSF in activated human T-cells. IL-7 down-regulates expression of TGF-beta in macrophages which has been suggested as an inhibitor of the antitumor immune response.

Swiss-Prot Accession Number: P13232