Interleukin-6 Simoa

Interleukin-6 (IL-6) is a secreted proinflammatory protein that is part of the IL-6 cytokine family. IL-6 is produced mainly by monocytes, macrophages, dendritic cells, and T cells, but other cells, such as epithelial cells, endothelial cells, fibroblasts, adipocytes, and keratinocytes, are capable of secreting IL-6 under inflammatory conditions. Several agents can induce IL-6 production, including pathogen-associated molecular patterns (PAMPs) such as toll-like receptor agonists and damage-associated molecular patterns (DAMPs) such as mitochondrial DNA. IL-6 signals through binding of either the membrane bound or soluble IL-6 receptor (mIL-6R, sIL-6) as it complexes and activates gp130. Membrane bound IL-6R expression is restricted to immune cells and hepatocytes. However, since nearly all cells express gp130, trans-signaling of IL-6 through binding to the sIL-6R can occur in any cell. IL-6 promotes induction of other inflammatory cytokines and chemokines and plays a role in recruitment of neutrophils and monocytes, promotion of B cell development, regulation of liver metabolism, and stimulation of tumor cell proliferation, survival and invasiveness. In addition, IL-6, in combination with TGF-a, induces development of TH17) cells and production of IL-17.

Swiss-Prot Accession Number: P05231