Interleukin-31 Simoa

Interleukin-31 (IL-31) is primary made by activated Th2-type T cells, eosinophils, mast cells, macrophages and dendritic cells. Its receptor, expressed primarily by monocytes, epithelial cells, and keratinocytes, is a heterodimer composed of the IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) and signals through JAK1/2 and STAT1/3/5. IL-31 regulates cell homeostasis, cell proliferation, tissue remodeling, and production of pro-inflammatory cytokines. High expression of IL-31 is known to promote several allergic and autoimmune diseases. Patients with various autoimmune skin diseases such as atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, bullous pemphigoid, psoriasis, prurigo nodularis and mastocytosis have increased serum IL-31.

Swiss-Prot Accession Number: Q6EBC2