Interleukin-21 Simoa

IL-21 is a type I cytokine and a member of the g chain (gc) family of cytokines. produced by various immune cells, including T follicular helper (Tfh) cells, CD4 and CD8 T cells, natural killer (NK) T cells, monocytes, macrophages, and dendritic cells. The IL-21 receptor is a heterodimer of IL-21R with the common gc, signaling through JAK1 and JAK3 and STAT3. IL-21 is a critical factor in Tfh and B cell interactions in the germinal center, and a potent stimulator of B cell proliferation, promotor of differentiation into plasma cells, and enhancer of antibody production. Additionally, IL-21 can also direct T cell differentiation, and enhance the cytotoxic activity of CD8 T cells and NK cells.

Swiss-Prot Accession Number: Q9HBE4