Interleukin-17C Simoa

Interleukin-17C (IL-17C) is one of six family members (17A-F) that constitute the IL-17 family of cytokines. IL-17C shares 23% homology with IL-17A and, like IL-17A and IL-17F, is a pro-inflammatory cytokine that is important for host defense. Inappropriate expression of IL-17C is implicated in the development of various inflammatory disorders. However, unlike other IL-17 family members, IL-17C is produced predominately by epithelial cells rather than immune cells, thus acting rapidly in an autocrine manner in response to epithelial injury. IL-17C binds to the IL-17RE receptor and appears to have overlapping signaling with IL-17A, inducing several cytokines and chemokines including CXCL1, IL-1, IL-8, CCL20, and IL-36. Additionally, IL-17C stimulates T helper 17 cells to increase the synthesis of IL-17A/F and IL-22 which promotes autoimmunity. IL-17C mRNA and protein have been shown to be increased in several inflammatory diseases including psoriasis, atopic dermatitis, immune-mediated glomerular disease, Crohn?s disease, and rheumatoid arthritis. IL-17C is also thought to be involved in tumorigenesis, particularly lung cancer and hepatocellular carcinoma.

Swiss-Prot Accession Number: Q9P0M4