Interleukin-16 (IL-16) was described originally as lymphocyte chemoattractant factor (LCF), which acts as a chemoattractant for CD4 (+) T-cells, macrophages, and eosinophils. The protein is produced by lymphocytes, eosinophils, mast cells, and lung epithelium. Fibroblasts from several tissues can express IL-16. Very high levels are produced in response to IL-1-beta.
A phase II clinical trial of the Vascular Disrupting Agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma (2013)Nowak AK, Brown C, Millward MJ, Creaney J, Byrne MJ, Hughes B, Kremmidiotis G, Bibby DC, Leske AF, Mitchell PL, Pavlakis N, Boyer M, Stockler MR Lung Cancer. 2013 Jun 17. pii: S0169-5002(13)00218-3
Integrative Omics Approach Identifies Interleukin-16 as a Biomarker of Emphysema (2013)Bowler RP, Bahr TM, Hughes G, Lutz S, Kim YI, Coldren CD, Reisdorph N, Kechris KJ OMICS. 2013 Oct 19. [Epub ahead of print]
Identification of blood protein biomarkers that aid in the clinical assessment of patients with malignant glioma (2012)Xu BJ, An QA, Srinivasa Gowda S, Yan W, Pierce LA, Abel TW, Rush SZ, Cooper MK, Ye F, Shyr Y, Weaver KD, Thompson RC Int J Oncol. 2012 Jun;40(6):1995-2003