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Immunoglobulin A

Immunoglobulin A

Secretory Immunoglobulin A (IgA) is found in tears, sweat, saliva, milk, colostrum, and in gastrointestinal and bronchial secretions. It protects the mucosa from bacteria and viruses. The presence of secretory IgA also affects the development of allergic (IgE) reactions to various ingested antigens by binding the antigens and preventing IgE responses. Increased serum IgA is common in patients with skin, gut, respiratory, renal infections and in ARC/AIDS. In portal cirrhosis, IgA and sometimes IgG are increased. Deficiency of IgA is found in one in 750 individuals. Absence of this immunoglobulin is also found in ataxia telangiectasia. A significant number of IgA-deficient individuals will have circulating anti-IgA, which can mediate fatal anaphylactoid reactions when sources of immunoglobulin are infused (e.g., blood component therapy).

Swiss-Prot Accession Number: P01876, P01877


Bibliography

SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus (2019) Smith MA, Henault J, Karnell JL, Parker ML, Riggs JM, Sinibaldi D, Taylor DK, Ettinger R, Grant EP, Sanjuan MA, Kolbeck R, Petri MA, Casey KA Scientific Reports

medical_services Therapy Indications
Autoimmune Disease and Arthritis

Extracorporeal apheresis therapy for Alzheimer disease-targeting lipids, stress, and inflammation (2019) Bornstein SR, Voit-Bak K, Rosenthal P, Tselmin S, Julius U, Schatz U, Boehm BO, Thuret S, Kempermann G, Reichmann H, Chrousos GP, Licinio J, Wong ML, Schally AV, Straube R Molecular Psychiatry

medical_services Therapy Indications
Neurological Disease

Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS (2018) Putcha N, Paul GG, Azar A, Wise RA, ONeal WK, Dransfield MT, Woodruff PG, Curtis JL, Comellas AP, Drummond MB, Lambert AA, Paulin LM, Fawzy A, Kanner RE, Paine R 3rd, Han MK, Martinez FJ, Bowler RP, Barr RG, Hansel NN, SPIROMICS investigators PLoS One

medical_services Therapy Indications
Pulmonary

Identifying amyloid pathology?related cerebrospinal fluid biomarkers for Alzheimers disease in a multicohort study (2015) Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, Soares HD, Kling MA, Mailman M, Arnold SE, Narayan VA, Lee VMY, Shaw LM, Baker D, Wittenberg GM, Trojanowski JQ, Wang LS Alzheimers & Dementia

medical_services Therapy Indications
Neurological Disease

Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program. (2009) Radonjic M, de Haan JR, van Erk MJ, van Dijk KW, van den Berg SA, de Groot PJ, M?ller M, van Ommen B PLoS ONE 4: e6646.

medical_services Therapy Indications
Diabetes and Metabolic Markers

Muscular Dystrophy Therapy by Nonautologous Mesenchymal Stem Cells: Muscle Regeneration Without Immunosuppression and Inflammation. (2009) Shabbir A, Zisa D, Leiker M, Johnston C, Lin H, Lee T Transplantation 87: 1275-1282.

medical_services Therapy Indications
Inflammation and Immune Response