Interferon gamma Olink

Interferon gamma (IFN-gamma, IFN gamma) is secreted by T cells (cytotoxic and Th1) and Natural Killer cells. Its major functions are to activate macrophages and to increase the expression of class II MHC on APC. IFN-gamma stimulated macrophages are more phagocytic, they are more capable of killing intracellular pathogens and they have increased ability to present antigen. IFN-gamma secreted by Th1 cells has a cross regulatory role in controlling Th2 function and will induce a class switch to IgG. It can inhibit the activities of the Th2 pathway by inducing macrophages to produce IL-12. This cytokine has a role in many types of immune responses such as delayed type hypersensitivity, inflammation, antibody production and viral infection.

Swiss-Prot Accession Number: P01579