I-309 (C-C motif chemokine ligand 1) Simoa

CCL1 (also known as I-309) is a C-C chemokine, which are small secreted proteins involved in cell trafficking. CCL1 is secreted by activated monocytes, macrophages, T cells, vascular smooth muscle cells, and umbilical vein endothelial cells. The receptor for CCL1 is CCR8, which is expressed mostly on T regulatory cells and to a lesser extent on T helper type 2 cells, monocytes, natural killer cells, and CD8 T cells. CCL1 is a potent chemoattractant of T cells and monocytes. The expression of CCL1 has been correlated to rheumatic heart disease, and atherosclerotic plaques have been demonstrated to express CCL1. Currently, CCL1 and its receptor CCR8 has shown to play a significant role in T regulatory cell (both CD4 and CD8) infiltration into the tumor microenvironment and suppression of anti-tumor immunity. For example, in breast cancer, CCL1 expression is elevated, associated with increased T regulatory cell infiltration, and correlated with poor survival. Recently, along with IL-11, the presence of CCL1 in bronchial alveolar lavage fluid samples may be a potential diagnostic marker for lung adenocarcinoma.

Swiss-Prot Accession Number: P22362