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HE4

HE4

HE4 is a protein that is encoded by the WFDC2 gene and functions as a broad range protease inhibitor. HE4 is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers.

Swiss-Prot Accession Number: Q14508


Bibliography

Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma (2016) Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ British Journal of Cancer

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Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4 (2013) OShannessy DJ, Somers EB, Palmer LM, Thiel RP, Oberoi P, Heath R, Marcucci L Journal of Ovarian Research 2013, 6:29

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