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Chemokine CC-4

Chemokine CC-4

Chemokine CC-4 (HCC-4; Hemofiltrate Chemokine-4; CCL16; Ncc-4). It is also known as liver-expressed chemokine (LEC) and lymphocyte monocyte chemoattractant. HCC-4 has been reported to signal through chemokine receptors CCR1, CCR2, CCR5 and CCR8. This chemokine is chemotactic for human monocytes and dendritic cells but not neutrophils. The presence of CCL16 in normal plasma at relatively high concentrations may modulate inflammatory responses.

Swiss-Prot Accession Number: O15467


Bibliography

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. (2017) Steele NZ, Carr JS, Bonham LS, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS PloS Med.

medical_services Therapy Indications
Neurological Disease

Genome-Wide Association Study of CSF Levels of 59 Alzheimers Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation (2014) Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S; Alzheimers Disease Neuroimaging Initiative, Fagan AM, Holtzman DM, Morris JC, Goate AM PLoS Genet

medical_services Therapy Indications
Neurological Disease