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Haptoglobin

Haptoglobin

Haptoglobin is produced in the liver and secreted into the blood, where it attaches to any "free" hemoglobin; that is, hemoglobin not contained within red blood cells. Haptoglobin is an acute phase protein used for the detection of in vivo hemolysis. The primary function of haptoglobin is the irreversible binding of free oxyhemoglobin in plasma. This complex is then removed by the reticuloendothelial system. Thus, haptoglobin prevents loss of hemoglobin to urine and conserves iron. Elevated values are present in chronic and acute inflammatory and neoplastic diseases. Decreased levels can indicate liver disease, hemolytic anemia, sickle cell anemia, and genetic haptoglobinemia.

Swiss-Prot Accession Number: P00738


Bibliography

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Elevated Carbon Monoxide to Carbon Dioxide Ratio in the Exhaled Breath of Mice Treated with a Single Dose of Lipopolysaccharide (2014) Langeroudi AG, Hirsch CM, Estabragh AS, Meinardi S, Blake DR, Barbour AG Open Forum Infectious Diseases

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Dose-related Differences in the Pharmacodynamic and Toxicologic Response to a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin in Sprague-Dawley Rats with Similarly High Hematocrit (2013) Andrews DA, Boren BM, Turk JR, Boyce RW, He YD, Hamadeh HK, Mytych DT, Barger TE, Salimi-Moosavi H, Sloey B, Elliott S, McElroy P, Sinclair AM, Shimamoto G, Pyrah IT, Lightfoot-Dunn RM Toxicol Pathol. 2013 May 14. [Epub ahead of print]

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Efficient Colonization and Therapy of Human Hepatocellular Carcinoma (HCC) Using the Oncolytic Vaccinia Virus Strain GLV-1h68 (2011) Gentschev I, M?ller M, Adelfinger M, Weibel S, Grummt F, Zimmermann M, Bitzer M, Heisig M, Zhang Q, Yu YA, Chen NG, Stritzker J, Lauer UM, Szalay AA PLoS ONE 6(7): e22069

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Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates. (2010) Olsen RJ, Kobayashi SD, Ayeras AA, Ashraf M, Graves SF, Ragasa W, Humbird T, Greaver JL, Cantu C, Swain JL, Jenkins L, Blasdel T, Cagle PT, Gardner DJ, DeLeo FR, Musser JM Am J Pathol 176: 1346-1354.

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