Granzyme B Simoa

Granzyme B is a serine protease produced by cytotoxic T lymphocytes, natural killer cells, and at lower levels by various cell types: mast cells, macrophages, plasmatoid dendritic cells, and others. It is reportedly to be the most potent of the human granzymes (there are 5 in total: A, B, H, K, and M). It?s mechanism of cell death involves cleaving proteins at the aspartic acid residues, and it can also directly activate the Bcl-2 and caspase pathways. Other mechanism of cell death activation have also been described. While normal healthy individuals have circulating granzyme B, elevated levels in plasma are linked to several diseases, including autoimmune skin diseases (lupus, psoriasis), rheumatoid arthritis, multiple sclerosis, viral infections, and others.

Swiss-Prot Accession Number: P10144