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Growth Hormone

Growth Hormone

Human growth hormone (GH; hGH; Somatotropin) is produced in and released from the acidophilic cells of the anterior pituitary gland. Basal levels of GH in normal individuals are usually less than 2 ng/mL and are stable throughout the day. Normal elevations in GH occur following meals, after exercise, and during sleep. Children who fail to grow at the expected rate and who have short stature with apparent normal body proportions often have a diminished capacity to secrete growth hormone. The deficiency may be either congenital or acquired. Growth hormone deficiency in both adults and children may be the direct result of neoplastic or infiltrative disease of the pituitary. It may also follow cranial irradiation for brain tumors and other neoplasms.

Swiss-Prot Accession Number: P01241


Bibliography

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Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome (2014) Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S Mol Autism. 2014 Jan 27;5(1):4

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Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia. (2014) van Beveren NJ, Schwarz E, Noll R, Guest PC, Meijer C, de Haan L, Bahn S. Translational Psychiatry 2014 Aug 26;4:e430. doi: 10.1038/tp.2014.52.

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A Canonical Transforming Growth Factor Beta-Dependent Signaling Pathway is Present in Peripheral Blood Cells of Cancer Patients with Skeletal Metastasis (2013) Kadam S, Cleverly AL, Farmen M, Grondin J, Cox YI, Lahn M J Mol Biomark Diagn 2013, 4:3

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The effects of stress on hypothalamic-pituitary-adrenal (HPA) axis function in subjects with schizophrenia (2013) Guest FL, Martins-de-Souza D, Rahmoune H, Bahn S, Guest PC Rev Psiq Cl?n. 2013;40(1):20-7

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