Growth/differentiation factor 15

GDF-15 belongs to the TGF beta superfamily and has a role in inflammatory and apoptotic pathways. Serum GDF-15 has been positively correlated with progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. GDF-15 is also upregulated by cardiovascular events triggering oxidative stress, including atherosclerosis. Increased circulating GDF-15 concentrations have been linked to an enhanced risk of future adverse cardiovascular events.

Swiss-Prot Accession Number: Q99988

Bibliography

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin (2016) Gerstein HC, Pare G, Hess S, Ford RJ, Sjaarda J, Raman K, McQueen M, Lee S, Haenel H, Steinberg GR; ORIGIN Investigators. Diabetes Care

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Growth/differentiation factor 15