Fibroblast Growth Factor 19

Fibroblast Growth Factor 19 is a member of the fibroblast growth factor (FGF) family. FGF-19 is produced in the ileum in response to?bile acid?absorption. FGF-19 governs embryonic development, tissue morphogenesis and repair, and tumor growth and invasion. FGF-19 negatively regulates the enzyme Cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis acting by means of its highly specific receptor, Fibroblast Growth Factor 4 (FGFR4).?Impaired FGF-19 activity is associated with the development of hypercholesterolemia, gall stones, bile acid induced diarrhea, hepatocellular cancer, colon cancer, and metabolic syndrome.

Swiss-Prot Accession Number: O95750

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Fibroblast Growth Factor 19