Factor VII
Factor VII plays a role in the coagulation cascade, the chain reaction that is set in motion when there is an injury to a blood vessel. There are two types of factor VII Deficiency: Inherited Factor VII Deficiency and Acquired Factor VII Deficiency, the latter which is the result of other physical disorders and may last only a short time. The inherited type of Factor VII Deficiency affects only one in a million people. However, one in 500 people may be a carrier of the defective gene. The acquired form of Factor VII Deficiency is more common and can result from severe liver disease which reduces the function of the liver (factor VII is produced in the liver) or they have low vitamin K levels as a result of taking certain kinds of medication. In addition, acquired Factor VII deficiency is associated with certain forms of cancer and autoimmune response to factor VII.
Swiss-Prot Accession Number: P08709
