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Epithelial-Derived Neutrophil-Activating Protein 78

Epithelial-Derived Neutrophil-Activating Protein 78

Epithelial-Derived Neutrophil-Activating Protein 78 (ENA-78, CXCL5) is a potent chemoattractant and activator of neutrophil functions. It is produced by many non-hematopoietic cell types. ENA-78 expression is elevated in the inflamed tissues of patients with rheumatoid arthritis, Crohns disease, ulcerative colitis, acute appendicitis, and allergic airway inflammation. ENA-78 is also a potent angiogenic factor in small lung cancer.

Swiss-Prot Accession Number: P42830


Bibliography

A phase 1b trial of the CXCR4 inhibitor mavorixafor and nivolumab in advanced renal cell carcinoma patients with no prior response to nivolumab monotherapy (2021) Choueiri TK, Atkins MB, Rose TL, Alter RS, Yawen J, Niland K, Wang Y, Arbeit R, Parasuraman S, Gan L, McDermott DF Investigational New Drugs

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Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort (2018) Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT, SPIROMICS investigators Respiratory Research

medical_services Therapy Indications

Biomarkers of Central Nervous System Inflammation in Infantile and Juvenile Gangliosidoses. (2014) Utz JR, Crutcher T, Schneider J, Sorgen P, Whitley CB. Mol Genet Metab. 2014 Dec 6. pii: S1096-7192(14)00376-X. doi: 10.1016/j.ymgme.2014.11.015. [Epub ahead of print]

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Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis (2012) Su?rez-Fari?as M, Li K, Fuentes-Duculan J, Hayden K, Brodmerkel C, Krueger JG J Invest Dermatol. 2012 Jul 5

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