Cancer Antigen 125
Cancer Antigen 125 (CA-125) is a glycoprotein found in increased amounts on the cell surface of many ovarian epithelial malignancies. Elevated levels of CA-125 are associated with serous, endometrioid, and clear cell carcinomas of the ovary. More than 80 percent of non-mucinous, epithelial ovarian carcinomas have elevated levels of CA-125. Conditions such as endometriosis, normal pregnancy, pelvic inflammatory disease, uterine fibroids, hepatitis, pancreatitis, and cirrhosis may contribute to elevated levels of serum CA-125. Malignancies of breast, lung, and gastrointestinal tract may also be associated with an elevation of this tumor marker.
Swiss-Prot Accession Number: Q8WXI7