B Lymphocyte Chemoattractant Simoa

B lymphocyte chemoattractant [BLC, CXCL13, B-cell-attracting chemokine-1 (BAC-1)] belongs to the CXC chemokine family and is expressed in the liver, follicles of the spleen, lymph nodes, and Peyer?s patches by T follicular helper cells, dendritic cells, osteoclasts, and macrophages. BLC induces B cell chemotaxis by binding to the chemokine receptor, CXCR5. CXCL13/CXCR5 signaling also promotes progression and lymph node metastases of oral squamous cell carcinoma, hepatocellular carcinoma, renal cell carcinoma, neuroblastoma, leukemias, multiple myelomas, lymphomas, breast cancers, colorectal cancers, lung cancers, and prostate cancers. T cell-mediated rejection of kidney allografts has been linked to B cell clustering and more severe disease. CXCL13 serum levels have been identified as a potential biomarker for B cell clustering and was correlated with more severe disease.

Swiss-Prot Accession Number: O43927