Adiponectin
Adiponectin
Adiponectin is a protein hormone that modulates a number of metabolic processes including glucose regulation and fatty acid catabolism. Secreted into the bloodstream exclusively from adipose tissue, adiponectin is very abundant in plasma relative to many hormones. Levels of the hormone are inversely correlated with body mass index (BMI). Adiponectin plays a role in the suppression of metabolic derangements that may result in type 2 diabetes, obesity, atherosclerosis and non-alcoholic fatty liver disease (NAFLD).
Swiss-Prot Accession Number: Q15848
Bibliography
Effect of pegbelfermin on NASH and fibrosis-related biomarkers and correlation with histological response in the FALCON 1 trial (2023) Elizabeth A. Brown, Anne Minnich, Arun J. Sanyal, Rohit Loomba, Shuyan Du, John Schwarz, Richard L. Ehman, Morten Karsdal, Diana J. Leeming, Giovanni Cizza, Edgar D. Charles JHEP Reports
medical_services Therapy IndicationsAmygdalar activity predicts future incident diabetes independently of adiposity (2019) Osborne MT, Ishai A, Hammad B, Tung B, Wang Y, Baruch A, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A Psychoneuroendocrinology
medical_services Therapy IndicationsAdiponectin in Relation to Coronary Plaque Characteristics on Radiofrequency Intravascular Ultrasound and Cardiovascular Outcome (2018) Marino BCA, Buljubasic N, Akkerhuis M, Cheng JM, Garcia-Garcia HM, Regar E, van Guens RJ, Serruys PW, Boersma E, Kardys I Sociedade Brasileira De Cardiologia
medical_services Therapy IndicationsSerum Proteomic Profiles of Depressive Subtypes (2016) Lamers F, Bot M, Jansen R, Chan MK, Cooper JD, Bahn S, Penninx BWJH Translational Psychiatry
medical_services Therapy IndicationsLower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease. (2014) Suzuki M, Makita H, Ostling J, Thomsen LH, Konno S, Nagai K, Shimizu K, Pedersen JH, Ashraf H, Bruijnzeel PL, Maciewicz RA, Nishimura M; for the Hokkaido COPD cohort study and DLCST investigators. Ann Am Thorac Soc. 2014 Nov 5. [Epub ahead of print]
medical_services Therapy IndicationsSingle-agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences (2012) Eve HE, Carey S, Richardson SJ, Heise CC, Mamidipudi V, Shi T, Radford JA, Auer RL, Bullard SH, Rule SA Br J Haematol. 2012 Aug 9.
medical_services Therapy IndicationsAdipocytokine signaling is altered in flinders sensitive line rats, and adiponectin correlates in humans with some symptoms of depression (2012) Wilhelm CJ, Choi D, Huckans M, Manthe L, Loftis JM Pharmacol Biochem Behav. 2012 Nov 12. pii: S0091-3057(12)00312-7
medical_services Therapy IndicationsAn Antiinflammatory Dietary Mix Modulates Inflammation and Oxidative and Metabolic Stress in Overweight Men: A Nutrigenomics Approach (2010) Bakker GC, Van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, Van Ommen B, Hendriks HF The American Journal of Clinical Nutrition
medical_services Therapy IndicationsA saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome (2009) van Dijk SJ, Feskens EJ, Bos MB, Hoelen DW, Heijligenberg R, Bromhaar MG, de Groot LC, de Vries JH, M?ller M, Afman LA Am J Clin Nutr. 90: 1656-64.
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