Angiotensin-Converting Enzyme
Angiotensin-Converting Enzyme (ACE) is a member of the angiotensin family which includes peptides that act as vasoconstricting agents. ACE converts angiotensin to its activated form (called angiotensin II). ACE is also involved in the inactivation of bradykinin, a potent vasodilator. These two actions make ACE an ideal target in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy and type 2 diabetes mellitus. Inhibition of ACE results in decreased formation of Angiotensin II (a far more potent vasoconstrictor than Angiotensin I) and decreased inactivation of bradykinin.
Swiss-Prot Accession Number: P12821
