6Ckine (CCL21) is named for its six conserved cysteine residues that distinguish it from typical chemokines that contain only four cysteines. It is highly expressed in the spleen, appendix, and the high endothelial venules of lymph nodes. 6Ckine stimulates chemotaxis of thymocytes and activated T cells and shows preferential activity towards naive T-cells. Unlike most CC chemokines, 6Ckine is not chemotactic for monocytes.
Swiss-Prot Accession Number: O00585
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