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Olink® Target and Explore HT — from Rules-Based Medicine

Offering scalable multiplexing while preserving sensitivity and specificity
Protein biomarkers are critical in understanding the mechanism of action behind different diseases and evaluating a patient’s therapeutic response. Rules-Based Medicine—a leader in proteomic testing for the past 20 years—performs Olink testing to improve the efficiency and precision of your clinical trials. Olink’s proximity extension assay (PEA®) delivers the throughput you need without compromising specificity or scalability. Whether you need a small panel of focused biomarkers or a comprehensive exploratory assessment, RBM has an Olink option to meet your needs. 

Exceptional Science

The Olink PEA technology employs a dual-recognition approach for enhanced sensitivity and specificity:

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Two antibodies labeled with complementary DNA oligonucleotides simultaneously bind to the target protein.

 

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The oligonucleotides are brought into close proximity and hybridize, creating a unique DNA barcode for each protein.

 

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This DNA barcode is is amplified by PCR, with readouts provided via quantitative PCR (qPCR) or next-generation sequencing (NGS).

 

Service Excellence

Olink is well suited to:

 

  • Evaluate therapeutic effects

    • Accurately measure at baseline and after treatment to understand the dynamic changes associated with a therapeutic candidate.

  • Understand disease onset and mechanism of action

    • Certain biomarkers are present years before diagnosis. Olink can help identify the relevant proteomic changes.

  • Develop biomarker signatures

    • Explore HT measures thousands of proteins at once. Longitudinal studies can help you understand proteomic profiles for different diseases.

  • Drug target identification

    • Disease-specific proteomic signatures can help identify potential drug targets.

Choose Olink assays from RBM for:

 

  • Exceptional sensitivity and specificity

    • Detect proteins at femtograms per milliliter

  • Low sample volume

    • Numerous assays performed from a single sample

  • Built-in quality controls

    • Internal and external controls in all biomarker panels

  • Scalability

    • Take your findings from discovery toward clinical translation

  • Disease-specific panels

    • Measure the markers most relevant to your therapeutic area of interest

 

Click each panel below to download an Excel file of the included analytes.

  Olink Explore series
~5,400 proteins, enabling comprehensive views across multiple conditions and mechanisms of action; ideal for population-scale and longitudinal studies. Readouts reported as NPX (normalized protein expression) units.*

Explore HT:  5400+ proteins

* NPX values are derived from Olink's PEA technology and next-generation sequencing (NGS) data. A difference of 1 NPX is equivalent to a doubling of protein concentration.

  Olink Target 48 Panels


 
Up to 45 proteins involved in inflammation and immune activity to deliver a comprehensive view of the immunological processes that occur across numerous conditions. Readouts reported as pg/mL.
 

Cytokine

Immune Surveillance

Neurodegeneration

  Olink Target 96 Panels
92 proteins associated with specific conditions or biological function, delivering multiplexed panels across several therapeutic areas. Readouts reported as NPX (normalized protein expression) units.*

Cardiovascular II

Immuno-Oncology

Neurology

Oncology II

Inflammation

Metabolism

Cardiovascular III

Immune Response

Neuro Exploratory

    

Mouse Exploratory

Cardiometabolic

          

* NPX values are derived from Olink's PEA technology and quantitative PCR (qPCR) data. A difference of 1 NPX is equivalent to a doubling of protein concentration.

Sample requirements

  • 1 aliquot of 40 µL plasma for Target 48 or Target 96.
  • 1 aliquot of 80 µL plasma for Explore HT.
  • Call client services for sample requirements when requesting Olink in addition to testing on other platforms.

Olink and PEA are registered trademarks and service marks of Olink Proteomics.

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