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Immunoassays to support your clinical trials for Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions

 

Rules-Based Medicine offers multiple platforms to support the development of new diagnostics and therapeutics, including Alamar NULISAseq, Olink Explore HT and Target platforms, and internally developed Simoa-based assays. CNS biomarkers show promise in diagnosing neurological disorders and injuries, monitoring disease progression, and evaluating potential therapies in clinical trials.

 

While CSF protein biomarkers remain the gold standard, blood-based biomarkers offer the advantages of providing broader, more equitable access to testing, faster and easier sample collection, and ultimately, opportunities for earlier diagnosis and treatment. Our platforms have demonstrated success in accurately quantifying the lower levels of CSF biomarkers leaking into the bloodstream.

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Our menu of internally developed Simoa-based assays have been validated in serum, plasma and CSF:

 
BIOMARKER LLOQ*
(SERUM AND PLASMA)		 LLOQ*
(UNDILUTED SAMPLES)		 VOLUME REQUIRED PLATFORM
Serum or plasma Other fluids**
Alpha-synuclein Simoa (A-Syn Simoa) 0.20 ng/mL 0.01 ng/mL 100 µL 150 µL Simoa
Beta Amyloid 40 (AB40) 28 pg/mL 5.6 pg/mL 100 µL 150 µL Simoa
Beta Amyloid 42 (AB42) 47 pg/mL 4.7 pg/mL 50 µL 150 µL Simoa
Glial Fibrillary Acidic Protein (GFAP) 0.70 pg/mL 0.175 pg/mL 100 µL 150 µL Simoa
Glycoprotein non-metastatic melanoma protein B (GPNMB) 8.1 ng/mL 0.203 ng/mL 50 µL 100 µL Luminex
Myeloid cell surface antigen CD33 (CD33) 0.11 ng/mL 0.0022 ng/mL 100 µL 150 µL Simoa
Neurofilament Light Chain (NF-L) 1.00 pg/mL 0.25 pg/mL 100 µL 150 µL Simoa
Neurofilament heavy polypeptide – phosphorylated (pNF-H) 3.8 pg/mL 0.95 pg/mL 100 µL 150 µL Simoa
Phospho-Tau181 (pTau181) 0.28 pg/mL 1.4 pg/mL 150 µL 150 µL Simoa
Phospho-Tau217 (pTau217) 0.027 pg/mL 0.00675 pg/mL 100 µL 150 µL Simoa
Phospho-Tau231 (pTau231) 0.31 pg/mL 0.155 pg/mL 150 µL 150 µL Simoa
Synaptosomal-associated protein 25 Simoa 3.2 pg/mL 0.8 pg/mL 100 µL 150 µL Simoa
Tau 0.22 pg/mL 0.055 pg/mL  100 µL 150 µL Simoa
Triggering receptor expressed on myeloid cells-1 Simoa (TREM-1 Simoa)  0.94 pg/mL  0.094 pg/mL  50 µL  50 µL Simoa
Triggering Receptor Expressed On Myeloid Cells 2 Simoa (TREM2 Simoa) 0.59 ng/mL 0.59 ng/mL 100 µL 150 µL Simoa

RBM also offers Olink panels to support your CNS clinical trials:

 

 

Available Olink CNS panels
  Olink Panel   No. of biomarkers   Download a list of biomarkers
Target 48 Neurodegeneration  45 Target 48 Neurodegeneration
Target 96 Neurology  92 Target 96 Neurology
Target 96 Neuro Exploratory  92  Target 96 Neuro Exploratory
Explore HT  5400 Explore HT

 Review our complete Olink menu.

 

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NULISAseq CNS Disease Panel 120

 

Detect 120 proteins from low sample volumes with exceptional sensitivity and high reproducibility. 

 

Request more information about our Alamar, Olink & Simoa CNS assays: