Interleukin-8 Simoa

Interleukin-8 (IL-8, CXCL8, GCP-1, or NAP-1) is a proinflammatory chemokine produced by many cell types including those involved in innate immunity, especially monocytes and epithelial cells.? IL-8 induces neutrophil chemotaxis and phagocytosis in response to infections. An ELR motif, which is responsible for the protein?s angiogenic properties is at the N-terminus of the protein. IL-8 can homodimerize or can form a heterodimer with CXCL4/PF4. The monomer and homodimer forms of IL-8 bind to and induce activation of chemokine receptors CXCR1 and CXCR2. IL-8 induction of CXCR1 triggers neutrophil antimicrobial activation and migration to sites of infection or inflammation and has been associated with obesity. IL-8 is a proinflammatory mediator in gingivitis and psoriasis and may be a factor in colorectal cancer. The angiogenic property of IL-8 has been implicated in driving angiogenesis in several cancers including gastric cancers and head and neck cancers. IL-8 is a regulator of the central nervous system (CNS) function and development and plays a key role in gliomas. High levels of maternal IL-8 have been associated with increased risk of schizophrenia and it has been implicated in cystic fibrosis.

Swiss-Prot Accession Number: P10145